INCREASE OF ENDO-PEPTIDASES AND EXO-PEPTIDASES IN THYROID-TUMORS

  • Authors:
    • LA AKSLEN
    • JE VARHAUG
    • T AAS
    • KJ ANDERSEN
  • View Affiliations

  • Published online on: September 1, 1994     https://doi.org/10.3892/or.1.5.953
  • Pages: 953-956
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Abstract

Production of proteolytic enzymes is important for the invasive properties of malignant tumours. In this series of 43 cases of various non-neoplastic and neoplastic thyroid lesions, the activity of dipeptidyl peptidase I and dipeptidyl peptidase IV was increased in papillary carcinomas. In addition, cathepsin B and cathepsin L were markedly elevated in 2 of 3 follicular carcinomas, and tryptase, which is a marker of mast cells, was also significantly elevated in follicular carcinomas. Our results indicate that proteolytic proteins are important in thyroid carcinomas, and in addition there seem to be some differences between papillary and follicular tumours. Larger studies are needed to confirm these findings.

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September 1994
Volume 1 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
AKSLEN L, VARHAUG J, AAS T and ANDERSEN K: INCREASE OF ENDO-PEPTIDASES AND EXO-PEPTIDASES IN THYROID-TUMORS. Oncol Rep 1: 953-956, 1994.
APA
AKSLEN, L., VARHAUG, J., AAS, T., & ANDERSEN, K. (1994). INCREASE OF ENDO-PEPTIDASES AND EXO-PEPTIDASES IN THYROID-TUMORS. Oncology Reports, 1, 953-956. https://doi.org/10.3892/or.1.5.953
MLA
AKSLEN, L., VARHAUG, J., AAS, T., ANDERSEN, K."INCREASE OF ENDO-PEPTIDASES AND EXO-PEPTIDASES IN THYROID-TUMORS". Oncology Reports 1.5 (1994): 953-956.
Chicago
AKSLEN, L., VARHAUG, J., AAS, T., ANDERSEN, K."INCREASE OF ENDO-PEPTIDASES AND EXO-PEPTIDASES IN THYROID-TUMORS". Oncology Reports 1, no. 5 (1994): 953-956. https://doi.org/10.3892/or.1.5.953