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AMPLIFICATION ON CHROMOSOMES 1P31, 1Q21-24, 5P13-14, AND 11P12-14 IN OVARIAN-CARCINOMA DETECTED BY REVERSE CHROMOSOME PAINTING

  • Authors:
    • U FISCHER
    • HP SATTLER
    • H BONKHOFF
    • M HERRMANN
    • B WULLICH
    • EU MEESE

  • View Affiliations

  • Published online on: November 1, 1994     https://doi.org/10.3892/or.1.6.1069
  • Pages: 1069-1073
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Abstract

Recently, amplifications of several genes including c-myc, HER-2/neu, and FGF-3 (int-2) have been identified in ovarian carcinomas. We analyzed Il tumor samples from ovarian carcinoma for gene amplification using reverse chromosome painting and standard Southern blot analysis. Reverse chromosome painting detected four amplified domains on chromosome bands 1p31, 1q21-24, 5p13-14, and 11p12-14. None of the amplified domains contained genes previously reported to be amplified in ovarian carcinomas. Southern blot analysis revealed amplifications of genes HER2/neu, N-ras and H-ras. Tumor T3711 showed three independent amplifications including chromosome bands 1p31, 11p12-14 and the HER-2/neu gene (17q11.2-12).

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November 1994
Volume 1 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
FISCHER U, SATTLER H, BONKHOFF H, HERRMANN M, WULLICH B and MEESE E: AMPLIFICATION ON CHROMOSOMES 1P31, 1Q21-24, 5P13-14, AND 11P12-14 IN OVARIAN-CARCINOMA DETECTED BY REVERSE CHROMOSOME PAINTING. Oncol Rep 1: 1069-1073, 1994
APA
FISCHER, U., SATTLER, H., BONKHOFF, H., HERRMANN, M., WULLICH, B., & MEESE, E. (1994). AMPLIFICATION ON CHROMOSOMES 1P31, 1Q21-24, 5P13-14, AND 11P12-14 IN OVARIAN-CARCINOMA DETECTED BY REVERSE CHROMOSOME PAINTING. Oncology Reports, 1, 1069-1073. https://doi.org/10.3892/or.1.6.1069
MLA
FISCHER, U., SATTLER, H., BONKHOFF, H., HERRMANN, M., WULLICH, B., MEESE, E."AMPLIFICATION ON CHROMOSOMES 1P31, 1Q21-24, 5P13-14, AND 11P12-14 IN OVARIAN-CARCINOMA DETECTED BY REVERSE CHROMOSOME PAINTING". Oncology Reports 1.6 (1994): 1069-1073.
Chicago
FISCHER, U., SATTLER, H., BONKHOFF, H., HERRMANN, M., WULLICH, B., MEESE, E."AMPLIFICATION ON CHROMOSOMES 1P31, 1Q21-24, 5P13-14, AND 11P12-14 IN OVARIAN-CARCINOMA DETECTED BY REVERSE CHROMOSOME PAINTING". Oncology Reports 1, no. 6 (1994): 1069-1073. https://doi.org/10.3892/or.1.6.1069