EFFECTS OF DELTA(7)-PROSTAGLANDIN A(1) METHYL-ESTER ON HUMAN OVARIAN-CANCER CELL-GROWTH IN-VITRO AND IN NUDE-MICE

  • Authors:
    • T KITA
    • Y KIKUCHI
    • J HIRATA
    • I NAGATA
    • S FUKUSHIMA
    • M FUKUSHIMA
  • View Affiliations

  • Published online on: November 1, 1994     https://doi.org/10.3892/or.1.6.1117
  • Pages: 1117-1122
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Abstract

The antitumor activities of Delta(7)-prostaglandin A(1) methyl ester (Delta(7)-PGA(1)) and Delta(7)-PGA(1) emulsified in lecithin oil (lipo Delta(7)-PGA(1)) were studied in nude mice models with ascites or solid tumors formed by i.p. or s.c. inoculation of human ovarian cancer cells (HRA). Inhibitory effects of Delta(7)-PGA(1), on the HRA cell proliferation in vitro were about 3.8-fold higher than those of lipo Delta(7)-PGA(1). In the ascites tumor model, the median survival in a CDDP alone treated group among alone treated groups was longest and followed by a Delta(7)-PGA(1) alone treated group. A combination of CDDP and Delta(7)-PGA(1) resulted in a significant (p<0.05) prolongation of the median survival, compared to that in any alone treated group, while even when CDDP was combined with lipo Delta(7)-PGA(1) the survival was not improved, compared to that in a CDDP alone treated group. In addition, analyses of the survival curve revealed that a combination of CDDP with Delta(7)-PGA(1) resulted in higher survival rate than with lipo Delta(7)-PGA(1). On the other hand, in the s.c. tumor model lipo Delta(7)-PGA(1) (but not Delta(7)-PGA(1)) significantly (p<0.05) inhibited the tumor growth. When combining lipo Delta(7)-PGA(1) with CDDP, its inhibitory effect was further enhanced. Subsequently, the survival time in a lipo Delta(7)-PGA(1)+CDDP treated group was longest and 3 out of 9 mice survived more than 100 days. Taken together, we conclude that Delta(7)-PGA(1) might be suitable for local treatment in i.p, ascites tumors while lipo Delta(7)-PGA(1) is useful for remote treatment in s.c. solid tumors.

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November 1994
Volume 1 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
KITA T, KIKUCHI Y, HIRATA J, NAGATA I, FUKUSHIMA S and FUKUSHIMA M: EFFECTS OF DELTA(7)-PROSTAGLANDIN A(1) METHYL-ESTER ON HUMAN OVARIAN-CANCER CELL-GROWTH IN-VITRO AND IN NUDE-MICE. Oncol Rep 1: 1117-1122, 1994
APA
KITA, T., KIKUCHI, Y., HIRATA, J., NAGATA, I., FUKUSHIMA, S., & FUKUSHIMA, M. (1994). EFFECTS OF DELTA(7)-PROSTAGLANDIN A(1) METHYL-ESTER ON HUMAN OVARIAN-CANCER CELL-GROWTH IN-VITRO AND IN NUDE-MICE. Oncology Reports, 1, 1117-1122. https://doi.org/10.3892/or.1.6.1117
MLA
KITA, T., KIKUCHI, Y., HIRATA, J., NAGATA, I., FUKUSHIMA, S., FUKUSHIMA, M."EFFECTS OF DELTA(7)-PROSTAGLANDIN A(1) METHYL-ESTER ON HUMAN OVARIAN-CANCER CELL-GROWTH IN-VITRO AND IN NUDE-MICE". Oncology Reports 1.6 (1994): 1117-1122.
Chicago
KITA, T., KIKUCHI, Y., HIRATA, J., NAGATA, I., FUKUSHIMA, S., FUKUSHIMA, M."EFFECTS OF DELTA(7)-PROSTAGLANDIN A(1) METHYL-ESTER ON HUMAN OVARIAN-CANCER CELL-GROWTH IN-VITRO AND IN NUDE-MICE". Oncology Reports 1, no. 6 (1994): 1117-1122. https://doi.org/10.3892/or.1.6.1117