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MEDROXYPROGESTERONE ACETATE (MPA) INCREASES PAI-1 SECRETION FROM HUVEC AND ELEVATES THE PLASMA-LEVELS OF PAI-I IN-VIVO

  • Authors:
    • K SERIZAWA
    • T URANO
    • Y KOJIMA
    • H IHARA
    • Y TAKADA
    • S TAKEUCHI
    • A TAKADA

  • View Affiliations

  • Published online on: November 1, 1994     https://doi.org/10.3892/or.1.6.1127
  • Pages: 1127-1130
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Abstract

Plasma levels of tissue type plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) in patients administered with medroxyprogesterone acetate (MPA) (800 mg/day) or tamoxifen (20 mg/day) were assayed. Active free PAI-1 levels of patients given MPA were significantly higher than those either given tamoxifen or post adjuvant therapy, t-PA antigen levels were not different among the three groups. In in vitro study, treatment of cultured human umbilical vein endothelial cells (HUVEC) with MPA (10(-6)-10(-8) M) decreased PAI-1 levels significantly with a trend to decrease in t-PA levels.

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November 1994
Volume 1 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
SERIZAWA K, URANO T, KOJIMA Y, IHARA H, TAKADA Y, TAKEUCHI S and TAKADA A: MEDROXYPROGESTERONE ACETATE (MPA) INCREASES PAI-1 SECRETION FROM HUVEC AND ELEVATES THE PLASMA-LEVELS OF PAI-I IN-VIVO. Oncol Rep 1: 1127-1130, 1994
APA
SERIZAWA, K., URANO, T., KOJIMA, Y., IHARA, H., TAKADA, Y., TAKEUCHI, S., & TAKADA, A. (1994). MEDROXYPROGESTERONE ACETATE (MPA) INCREASES PAI-1 SECRETION FROM HUVEC AND ELEVATES THE PLASMA-LEVELS OF PAI-I IN-VIVO. Oncology Reports, 1, 1127-1130. https://doi.org/10.3892/or.1.6.1127
MLA
SERIZAWA, K., URANO, T., KOJIMA, Y., IHARA, H., TAKADA, Y., TAKEUCHI, S., TAKADA, A."MEDROXYPROGESTERONE ACETATE (MPA) INCREASES PAI-1 SECRETION FROM HUVEC AND ELEVATES THE PLASMA-LEVELS OF PAI-I IN-VIVO". Oncology Reports 1.6 (1994): 1127-1130.
Chicago
SERIZAWA, K., URANO, T., KOJIMA, Y., IHARA, H., TAKADA, Y., TAKEUCHI, S., TAKADA, A."MEDROXYPROGESTERONE ACETATE (MPA) INCREASES PAI-1 SECRETION FROM HUVEC AND ELEVATES THE PLASMA-LEVELS OF PAI-I IN-VIVO". Oncology Reports 1, no. 6 (1994): 1127-1130. https://doi.org/10.3892/or.1.6.1127