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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 1994 Volume 1 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 1994 Volume 1 Issue 6

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Article

A SHORT-TERM INFUSION REGIMEN OF CISPLATIN, 5-FLUOROURACIL AND L-FOLINIC ACID IN ADVANCED HEAD AND NECK-CARCINOMA

  • Authors:
    • M MELI
    • S PALMERI
    • V LEONARDI
    • M DANOVA
    • G FAILLA
    • A RUSSO
    • S BRUGNATELLI
    • P FERRARA
    • M BENAZZO
    • L RAUSA

  • View Affiliations / Copyright

    Affiliations: POLICLIN P GIACCONE,SERV CENT ONCOL MED,I-90127 PALERMO,ITALY. POLICLIN SAN MATTEO,IRCCS,PAVIA,ITALY. UNIV PAVIA,OTORINOLARINGOIATR CLIN,PAVIA,ITALY. POLICLIN P GIACCONE,OTORINOLARINGOIATR CLIN R,PALERMO,ITALY. UNIV PAVIA,COOPERAT ONCOL SICILIANO GRP,PAVIA,ITALY. OSPED S LUIGI SANTI CURRO,CATANIA,ITALY.
  • Pages: 1133-1138
    |
    Published online on: November 1, 1994
       https://doi.org/10.3892/or.1.6.1133
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Abstract

Treatment of advanced head and neck cancer is still a matter of controversy. Although current chemotherapy regimens are able to induce high response rates, they have not shown improved survival. We employed a combination of cisplatin (CDDP), 5-fluorouracil (5FU) and 1-folinic acid (1-FA) in a 6-hour infusion schedule easy to administer on an outpatient basis. 49 patients have been included to date. The treatment plan consists of 5-FU (375 mg/m(2)) plus 1-FA (100 mg/m(2)) in a 4-hour i.v. infusion followed by a 2-hour i.v. administration of CDDP (20 mg/m(2)). This therapy was repeated for five consecutive days and recycled every 3-4 weeks. Out of 46 evaluable patients there were 6 complete responses (CR) and 23 partial responses (PR) for an overall response rate of 63%. Overall survival was 10.2 months (mean). Untreated patients had a higher probability of response as well as patients with naso-oropharyngeal primary tumor. Toxicity was generally mild with leukopenia, anemia and vomiting being the most frequent side effects. In conclusion, this combination appears well tolerated and active in the palliation of advanced head and neck cancer. However we think that increasing dose intensity of standard regimens and experimental new therapeutic approaches are needed to improve the clinical outcome of this disease.

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Copy and paste a formatted citation
Spandidos Publications style
MELI M, PALMERI S, LEONARDI V, DANOVA M, FAILLA G, RUSSO A, BRUGNATELLI S, FERRARA P, BENAZZO M, RAUSA L, RAUSA L, et al: A SHORT-TERM INFUSION REGIMEN OF CISPLATIN, 5-FLUOROURACIL AND L-FOLINIC ACID IN ADVANCED HEAD AND NECK-CARCINOMA. Oncol Rep 1: 1133-1138, 1994.
APA
MELI, M., PALMERI, S., LEONARDI, V., DANOVA, M., FAILLA, G., RUSSO, A. ... RAUSA, L. (1994). A SHORT-TERM INFUSION REGIMEN OF CISPLATIN, 5-FLUOROURACIL AND L-FOLINIC ACID IN ADVANCED HEAD AND NECK-CARCINOMA. Oncology Reports, 1, 1133-1138. https://doi.org/10.3892/or.1.6.1133
MLA
MELI, M., PALMERI, S., LEONARDI, V., DANOVA, M., FAILLA, G., RUSSO, A., BRUGNATELLI, S., FERRARA, P., BENAZZO, M., RAUSA, L."A SHORT-TERM INFUSION REGIMEN OF CISPLATIN, 5-FLUOROURACIL AND L-FOLINIC ACID IN ADVANCED HEAD AND NECK-CARCINOMA". Oncology Reports 1.6 (1994): 1133-1138.
Chicago
MELI, M., PALMERI, S., LEONARDI, V., DANOVA, M., FAILLA, G., RUSSO, A., BRUGNATELLI, S., FERRARA, P., BENAZZO, M., RAUSA, L."A SHORT-TERM INFUSION REGIMEN OF CISPLATIN, 5-FLUOROURACIL AND L-FOLINIC ACID IN ADVANCED HEAD AND NECK-CARCINOMA". Oncology Reports 1, no. 6 (1994): 1133-1138. https://doi.org/10.3892/or.1.6.1133
Copy and paste a formatted citation
x
Spandidos Publications style
MELI M, PALMERI S, LEONARDI V, DANOVA M, FAILLA G, RUSSO A, BRUGNATELLI S, FERRARA P, BENAZZO M, RAUSA L, RAUSA L, et al: A SHORT-TERM INFUSION REGIMEN OF CISPLATIN, 5-FLUOROURACIL AND L-FOLINIC ACID IN ADVANCED HEAD AND NECK-CARCINOMA. Oncol Rep 1: 1133-1138, 1994.
APA
MELI, M., PALMERI, S., LEONARDI, V., DANOVA, M., FAILLA, G., RUSSO, A. ... RAUSA, L. (1994). A SHORT-TERM INFUSION REGIMEN OF CISPLATIN, 5-FLUOROURACIL AND L-FOLINIC ACID IN ADVANCED HEAD AND NECK-CARCINOMA. Oncology Reports, 1, 1133-1138. https://doi.org/10.3892/or.1.6.1133
MLA
MELI, M., PALMERI, S., LEONARDI, V., DANOVA, M., FAILLA, G., RUSSO, A., BRUGNATELLI, S., FERRARA, P., BENAZZO, M., RAUSA, L."A SHORT-TERM INFUSION REGIMEN OF CISPLATIN, 5-FLUOROURACIL AND L-FOLINIC ACID IN ADVANCED HEAD AND NECK-CARCINOMA". Oncology Reports 1.6 (1994): 1133-1138.
Chicago
MELI, M., PALMERI, S., LEONARDI, V., DANOVA, M., FAILLA, G., RUSSO, A., BRUGNATELLI, S., FERRARA, P., BENAZZO, M., RAUSA, L."A SHORT-TERM INFUSION REGIMEN OF CISPLATIN, 5-FLUOROURACIL AND L-FOLINIC ACID IN ADVANCED HEAD AND NECK-CARCINOMA". Oncology Reports 1, no. 6 (1994): 1133-1138. https://doi.org/10.3892/or.1.6.1133
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