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ETOPOSIDE PHARMACOKINETICS IN A JAUNDICED INFANT WITH LETTERER-SIWE VARIANT OF LANGERHANS CELL HISTIOCYTOSIS

  • Authors:
    • PN PLOWMAN
    • SP JOEL
    • S HERMAN

  • View Affiliations

  • Published online on: November 1, 1994     https://doi.org/10.3892/or.1.6.1233
  • Pages: 1233-1234
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

An infant with hepatocellular jaundice due to Langerhans cell histiocytosis was treated and responded well to intravenous etoposide. Pharmacokinetics demonstrated similar clearance and AUC data in both the jaundiced and non-jaundiced states but myelosuppression was greater when the infant was jaundiced. Children with hepatocellular jaundice require dose reductions of etoposide, despite the similar drag pharmacokinetics to the non-jaundiced state. The mechanisms involved are discussed.

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November 1994
Volume 1 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 4.2
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
PLOWMAN P, JOEL S and HERMAN S: ETOPOSIDE PHARMACOKINETICS IN A JAUNDICED INFANT WITH LETTERER-SIWE VARIANT OF LANGERHANS CELL HISTIOCYTOSIS. Oncol Rep 1: 1233-1234, 1994
APA
PLOWMAN, P., JOEL, S., & HERMAN, S. (1994). ETOPOSIDE PHARMACOKINETICS IN A JAUNDICED INFANT WITH LETTERER-SIWE VARIANT OF LANGERHANS CELL HISTIOCYTOSIS. Oncology Reports, 1, 1233-1234. https://doi.org/10.3892/or.1.6.1233
MLA
PLOWMAN, P., JOEL, S., HERMAN, S."ETOPOSIDE PHARMACOKINETICS IN A JAUNDICED INFANT WITH LETTERER-SIWE VARIANT OF LANGERHANS CELL HISTIOCYTOSIS". Oncology Reports 1.6 (1994): 1233-1234.
Chicago
PLOWMAN, P., JOEL, S., HERMAN, S."ETOPOSIDE PHARMACOKINETICS IN A JAUNDICED INFANT WITH LETTERER-SIWE VARIANT OF LANGERHANS CELL HISTIOCYTOSIS". Oncology Reports 1, no. 6 (1994): 1233-1234. https://doi.org/10.3892/or.1.6.1233