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HUMAN AND XENOPUS MO15 MESSENGER-RNA ARE HIGHLY CONSERVED BUT SHOW DIFFERENT PATTERNS OF EXPRESSION IN ADULT TISSUES

  • Authors:
    • D KOBELT
    • T KARN
    • B HOCK
    • U HOLTRICH
    • A BRAUNINGER
    • G WOLF
    • K STREBHARDT
    • K RUBSAMENWAIGMANN

  • View Affiliations

  • Published online on: November 1, 1994     https://doi.org/10.3892/or.1.6.1269
  • Pages: 1269-1275
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Abstract

Phosphorylation of human p34(cdc2) at Thr 161 seems to be necessary for its catalytic activity. CAK (cdk activating kinase) containing p40(MO15) from Xenopus egg extracts phosphorylates and activates p34(cdc2) in a cyclin dependent manner at Thr 161. We describe the cDNA sequence coding for human MO15, which predicts a serine/threonine kinase of 346 aa. Despite the high homology of 91% between the human and Xenopus proteins we observed a rather different mRNA distribution in adult tissues: In contrast to ubiquitously expressed human MO15-transcripts MO15-mRNA expression in Xenopus is restricted to oocytes indicating a different cellular role in these two phylogenetically distant species. By virtue of the homology to members of the family of cell cycle kinase genes we examined MO15 mRNA expression for its correlation to the proliferative activity of cells. Stimulation of lymphocytes showed MO15 mRNA expression to be independent of mitotic activity.

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November 1994
Volume 1 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
KOBELT D, KARN T, HOCK B, HOLTRICH U, BRAUNINGER A, WOLF G, STREBHARDT K and RUBSAMENWAIGMANN K: HUMAN AND XENOPUS MO15 MESSENGER-RNA ARE HIGHLY CONSERVED BUT SHOW DIFFERENT PATTERNS OF EXPRESSION IN ADULT TISSUES. Oncol Rep 1: 1269-1275, 1994
APA
KOBELT, D., KARN, T., HOCK, B., HOLTRICH, U., BRAUNINGER, A., WOLF, G. ... RUBSAMENWAIGMANN, K. (1994). HUMAN AND XENOPUS MO15 MESSENGER-RNA ARE HIGHLY CONSERVED BUT SHOW DIFFERENT PATTERNS OF EXPRESSION IN ADULT TISSUES. Oncology Reports, 1, 1269-1275. https://doi.org/10.3892/or.1.6.1269
MLA
KOBELT, D., KARN, T., HOCK, B., HOLTRICH, U., BRAUNINGER, A., WOLF, G., STREBHARDT, K., RUBSAMENWAIGMANN, K."HUMAN AND XENOPUS MO15 MESSENGER-RNA ARE HIGHLY CONSERVED BUT SHOW DIFFERENT PATTERNS OF EXPRESSION IN ADULT TISSUES". Oncology Reports 1.6 (1994): 1269-1275.
Chicago
KOBELT, D., KARN, T., HOCK, B., HOLTRICH, U., BRAUNINGER, A., WOLF, G., STREBHARDT, K., RUBSAMENWAIGMANN, K."HUMAN AND XENOPUS MO15 MESSENGER-RNA ARE HIGHLY CONSERVED BUT SHOW DIFFERENT PATTERNS OF EXPRESSION IN ADULT TISSUES". Oncology Reports 1, no. 6 (1994): 1269-1275. https://doi.org/10.3892/or.1.6.1269