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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 1994 Volume 1 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 1994 Volume 1 Issue 6

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Article

HUMAN AND XENOPUS MO15 MESSENGER-RNA ARE HIGHLY CONSERVED BUT SHOW DIFFERENT PATTERNS OF EXPRESSION IN ADULT TISSUES

  • Authors:
    • D KOBELT
    • T KARN
    • B HOCK
    • U HOLTRICH
    • A BRAUNINGER
    • G WOLF
    • K STREBHARDT
    • K RUBSAMENWAIGMANN

  • View Affiliations / Copyright

    Affiliations: GEORG SPEYER HAUS,CHEMOTHERAPEUT FORSCHUNGSINST,D-60596 FRANKFURT,GERMANY.
  • Pages: 1269-1275
    |
    Published online on: November 1, 1994
       https://doi.org/10.3892/or.1.6.1269
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Abstract

Phosphorylation of human p34(cdc2) at Thr 161 seems to be necessary for its catalytic activity. CAK (cdk activating kinase) containing p40(MO15) from Xenopus egg extracts phosphorylates and activates p34(cdc2) in a cyclin dependent manner at Thr 161. We describe the cDNA sequence coding for human MO15, which predicts a serine/threonine kinase of 346 aa. Despite the high homology of 91% between the human and Xenopus proteins we observed a rather different mRNA distribution in adult tissues: In contrast to ubiquitously expressed human MO15-transcripts MO15-mRNA expression in Xenopus is restricted to oocytes indicating a different cellular role in these two phylogenetically distant species. By virtue of the homology to members of the family of cell cycle kinase genes we examined MO15 mRNA expression for its correlation to the proliferative activity of cells. Stimulation of lymphocytes showed MO15 mRNA expression to be independent of mitotic activity.

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Copy and paste a formatted citation
Spandidos Publications style
KOBELT D, KARN T, HOCK B, HOLTRICH U, BRAUNINGER A, WOLF G, STREBHARDT K and RUBSAMENWAIGMANN K: HUMAN AND XENOPUS MO15 MESSENGER-RNA ARE HIGHLY CONSERVED BUT SHOW DIFFERENT PATTERNS OF EXPRESSION IN ADULT TISSUES. Oncol Rep 1: 1269-1275, 1994.
APA
KOBELT, D., KARN, T., HOCK, B., HOLTRICH, U., BRAUNINGER, A., WOLF, G. ... RUBSAMENWAIGMANN, K. (1994). HUMAN AND XENOPUS MO15 MESSENGER-RNA ARE HIGHLY CONSERVED BUT SHOW DIFFERENT PATTERNS OF EXPRESSION IN ADULT TISSUES. Oncology Reports, 1, 1269-1275. https://doi.org/10.3892/or.1.6.1269
MLA
KOBELT, D., KARN, T., HOCK, B., HOLTRICH, U., BRAUNINGER, A., WOLF, G., STREBHARDT, K., RUBSAMENWAIGMANN, K."HUMAN AND XENOPUS MO15 MESSENGER-RNA ARE HIGHLY CONSERVED BUT SHOW DIFFERENT PATTERNS OF EXPRESSION IN ADULT TISSUES". Oncology Reports 1.6 (1994): 1269-1275.
Chicago
KOBELT, D., KARN, T., HOCK, B., HOLTRICH, U., BRAUNINGER, A., WOLF, G., STREBHARDT, K., RUBSAMENWAIGMANN, K."HUMAN AND XENOPUS MO15 MESSENGER-RNA ARE HIGHLY CONSERVED BUT SHOW DIFFERENT PATTERNS OF EXPRESSION IN ADULT TISSUES". Oncology Reports 1, no. 6 (1994): 1269-1275. https://doi.org/10.3892/or.1.6.1269
Copy and paste a formatted citation
x
Spandidos Publications style
KOBELT D, KARN T, HOCK B, HOLTRICH U, BRAUNINGER A, WOLF G, STREBHARDT K and RUBSAMENWAIGMANN K: HUMAN AND XENOPUS MO15 MESSENGER-RNA ARE HIGHLY CONSERVED BUT SHOW DIFFERENT PATTERNS OF EXPRESSION IN ADULT TISSUES. Oncol Rep 1: 1269-1275, 1994.
APA
KOBELT, D., KARN, T., HOCK, B., HOLTRICH, U., BRAUNINGER, A., WOLF, G. ... RUBSAMENWAIGMANN, K. (1994). HUMAN AND XENOPUS MO15 MESSENGER-RNA ARE HIGHLY CONSERVED BUT SHOW DIFFERENT PATTERNS OF EXPRESSION IN ADULT TISSUES. Oncology Reports, 1, 1269-1275. https://doi.org/10.3892/or.1.6.1269
MLA
KOBELT, D., KARN, T., HOCK, B., HOLTRICH, U., BRAUNINGER, A., WOLF, G., STREBHARDT, K., RUBSAMENWAIGMANN, K."HUMAN AND XENOPUS MO15 MESSENGER-RNA ARE HIGHLY CONSERVED BUT SHOW DIFFERENT PATTERNS OF EXPRESSION IN ADULT TISSUES". Oncology Reports 1.6 (1994): 1269-1275.
Chicago
KOBELT, D., KARN, T., HOCK, B., HOLTRICH, U., BRAUNINGER, A., WOLF, G., STREBHARDT, K., RUBSAMENWAIGMANN, K."HUMAN AND XENOPUS MO15 MESSENGER-RNA ARE HIGHLY CONSERVED BUT SHOW DIFFERENT PATTERNS OF EXPRESSION IN ADULT TISSUES". Oncology Reports 1, no. 6 (1994): 1269-1275. https://doi.org/10.3892/or.1.6.1269
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