Combination therapy with interferon α and β to chronic hepatitis C

Horiike,Norio; Hino,Hisako; Tanaka,Yoshikazu; Miyaoka,Hiroaki; Miki,Shigetaka; Yamashita,Syougo; Matsuura,Bunzo; Kubo,Yoshikazu; Ikeda,Yoshio; Akbar,S.M. Fazle; Masumoto,Toshikazu; Michitaka,Kojiro; Onji,Morikazu

doi:10.3892/or.10.1.157

January-February 2003 Volume 10 Issue 1

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January-February 2003 Volume 10 Issue 1

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Article

Combination therapy with interferon α and β to chronic hepatitis C

Authors:
- Norio Horiike
- Hisako Hino
- Yoshikazu Tanaka
- Hiroaki Miyaoka
- Shigetaka Miki
- Syougo Yamashita
- Bunzo Matsuura
- Yoshikazu Kubo
- Yoshio Ikeda
- S.M. Fazle Akbar
- Toshikazu Masumoto
- Kojiro Michitaka
- Morikazu Onji
View Affiliations / Copyright

Affiliations: The Third Department of Internal Medicine, Ehime University School of Medicine, Shitsukawa, Shigenobu-cho, Onsen-gun, Ehime 791-0295, Japan. horiike@m.ehime-u.ac.jp
Pages: 157-161
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Published online on: January 1, 2003

https://doi.org/10.3892/or.10.1.157
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Abstract

To increase the sustained response (SR) rate in chronic hepatitis C (CHC), we tried a combination therapy with interferon (IFN) α and β. Fifty patients were grouped into 4 groups: group 1H (n=9), HCV serotype 1 and high HCV-RNA titer (over 6 log copies/ml); group 1L (n=11), HCV serotype 1 and low HCV-RNA titer (less than 6 log copies/ml); group 2H (n=23), HCV serotype 2 and high HCV-RNA titer; group 2L (n=7), HCV serotype 2 and low HCV-RNA titer. They were given a total dose of 768 MIU which included natural IFN β (6 MIU) once daily for 28 consecutive days and then natural IFNα (10 MIU) three times a week for 20 weeks. Forty-nine patients with CHC receiving IFN α at total dose of 480 MIU served as single therapy group. In combination group, SR rate was achieved in 62%, 44% in 1H, 45% in 1L, 70% in 2H, and 86% in 2L, respectively. In single group, SR rate was achieved in 45, 14, 58, 60, and 82%, respectively. There was no significant difference for SR rate between combination group and single group. However, in patients with HCV-RNA titer between 6-7 log copies/ml of 1H group, SR rate in combination group (67%, 4/6) was significantly higher than that of single group (18%, 3/17) (p<0.05). These data suggest the usefulness of combination therapy with IFN α and β in CHC with serotype 1 having moderately high HCV-RNA titer.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Combination therapy with interferon α and β to chronic hepatitis C

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