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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January-February 2003 Volume 10 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January-February 2003 Volume 10 Issue 1

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Article

Prognostic significance of cell proliferation in human neuroblastoma: Comparison with other prognostic factors

  • Authors:
    • Carmen Mejía
    • Samuel Navarro
    • Antonio Pellín
    • Amparo Ruíz
    • Victoria Castel
    • Antonio Llombart-Bosch

  • View Affiliations / Copyright

    Affiliations: Department of Neurosciences, Institute of Cell Physiology, Universidad Nacional Autonoma de Mexico, Mexico City 04510, D.F. Mexico. mmejia@ifisiol.unam.mx
  • Pages: 243-247
    |
    Published online on: January 1, 2003
       https://doi.org/10.3892/or.10.1.243
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Abstract

Peripheral neuroblastic tumors (PNT), are heterogeneous neoplasms that include neuroblastoma (NB), ganglioneuroblastoma (GNB) and ganglioneuroma (GN) and present great biological heterogeneity. There are few reports analyzing PCNA and Ki-67 expression in PNT; however, controversy exists concerning the specificity of PCNA as a real proliferative marker. The objective of our study was to determine which of these cellular proliferation markers is more specific on cellular cycle and could contribute with more information on the cell cycle. We found that PCNA was expressed in NB unfavourable cases, with MYCN amplification and high mitosis-karyorrhexis-index (MKI). Whereas, Ki-67 showed statistical significance regarding cases unfavourable with intermediate and high MKI, aneuploid and stages 3 and 4. Survival showed that patients with tumor not expressing Ki-67 (MIB1) lived longer than those without PCNA (88.93 vs 74.05%). We conclude that Ki-67 expression permits reliable detection of the cellular proliferation neuroblastoma fraction and provides useful prognostic information when associated with other biological factors.

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Copy and paste a formatted citation
Spandidos Publications style
Mejía C, Navarro S, Pellín A, Ruíz A, Castel V and Llombart-Bosch A: Prognostic significance of cell proliferation in human neuroblastoma: Comparison with other prognostic factors. Oncol Rep 10: 243-247, 2003.
APA
Mejía, C., Navarro, S., Pellín, A., Ruíz, A., Castel, V., & Llombart-Bosch, A. (2003). Prognostic significance of cell proliferation in human neuroblastoma: Comparison with other prognostic factors. Oncology Reports, 10, 243-247. https://doi.org/10.3892/or.10.1.243
MLA
Mejía, C., Navarro, S., Pellín, A., Ruíz, A., Castel, V., Llombart-Bosch, A."Prognostic significance of cell proliferation in human neuroblastoma: Comparison with other prognostic factors". Oncology Reports 10.1 (2003): 243-247.
Chicago
Mejía, C., Navarro, S., Pellín, A., Ruíz, A., Castel, V., Llombart-Bosch, A."Prognostic significance of cell proliferation in human neuroblastoma: Comparison with other prognostic factors". Oncology Reports 10, no. 1 (2003): 243-247. https://doi.org/10.3892/or.10.1.243
Copy and paste a formatted citation
x
Spandidos Publications style
Mejía C, Navarro S, Pellín A, Ruíz A, Castel V and Llombart-Bosch A: Prognostic significance of cell proliferation in human neuroblastoma: Comparison with other prognostic factors. Oncol Rep 10: 243-247, 2003.
APA
Mejía, C., Navarro, S., Pellín, A., Ruíz, A., Castel, V., & Llombart-Bosch, A. (2003). Prognostic significance of cell proliferation in human neuroblastoma: Comparison with other prognostic factors. Oncology Reports, 10, 243-247. https://doi.org/10.3892/or.10.1.243
MLA
Mejía, C., Navarro, S., Pellín, A., Ruíz, A., Castel, V., Llombart-Bosch, A."Prognostic significance of cell proliferation in human neuroblastoma: Comparison with other prognostic factors". Oncology Reports 10.1 (2003): 243-247.
Chicago
Mejía, C., Navarro, S., Pellín, A., Ruíz, A., Castel, V., Llombart-Bosch, A."Prognostic significance of cell proliferation in human neuroblastoma: Comparison with other prognostic factors". Oncology Reports 10, no. 1 (2003): 243-247. https://doi.org/10.3892/or.10.1.243
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