Expression of matrix metalloproteinases in human transitional cell carcinoma of the urinary bladder

  • Authors:
    • Toshiyuki Sumi
    • Hiroyuki Yoshida
    • Yoji Hyun
    • Tomoyo Yasui
    • Yoshinari Matsumoto
    • Kanae Hattori
    • Kazunobu Sugimura
    • Hidenori Kawashima
    • Tatsuya Nakatani
    • Osamu Ishiko
  • View Affiliations

  • Published online on: March 1, 2003     https://doi.org/10.3892/or.10.2.345
  • Pages: 345-349
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Matrix metalloproteinases (MMPs) are associated with invasion and metastasis of several human malignant tumors. Especially so MMP-7, as it is mainly produced by the actual cancer cells. However, the expression of MMP-7 in transitional cell carcinoma (TCC) of the urinary bladder has not been previously investigated. We examined expressions of MMP-7 and MMP-2 in TCC, and compared them with clinicopathological characteristics in TCCs. Tumor samples from 20 patients with TCC of the urinary bladder who had surgery performed at the Osaka City University Medical School Hospital were immunohistochemically stained. Expression of MMP-2 was significantly stronger in advanced stage and high grade tumors than in low stage and low grade tumors. MMP-7 was also expressed in TCC, having a tendency to be more strongly expressed in high than in low grade tumors. However, there was no significant difference of MMP-7 expression between advanced and low stages. This increased expression of MMP-7 in high grade TCC of the urinary bladder may be associated with tumor invasion and metastasis.

Related Articles

Journal Cover

March-April 2003
Volume 10 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Sumi T, Yoshida H, Hyun Y, Yasui T, Matsumoto Y, Hattori K, Sugimura K, Kawashima H, Nakatani T, Ishiko O, Ishiko O, et al: Expression of matrix metalloproteinases in human transitional cell carcinoma of the urinary bladder. Oncol Rep 10: 345-349, 2003
APA
Sumi, T., Yoshida, H., Hyun, Y., Yasui, T., Matsumoto, Y., Hattori, K. ... Ishiko, O. (2003). Expression of matrix metalloproteinases in human transitional cell carcinoma of the urinary bladder. Oncology Reports, 10, 345-349. https://doi.org/10.3892/or.10.2.345
MLA
Sumi, T., Yoshida, H., Hyun, Y., Yasui, T., Matsumoto, Y., Hattori, K., Sugimura, K., Kawashima, H., Nakatani, T., Ishiko, O."Expression of matrix metalloproteinases in human transitional cell carcinoma of the urinary bladder". Oncology Reports 10.2 (2003): 345-349.
Chicago
Sumi, T., Yoshida, H., Hyun, Y., Yasui, T., Matsumoto, Y., Hattori, K., Sugimura, K., Kawashima, H., Nakatani, T., Ishiko, O."Expression of matrix metalloproteinases in human transitional cell carcinoma of the urinary bladder". Oncology Reports 10, no. 2 (2003): 345-349. https://doi.org/10.3892/or.10.2.345