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Preoperative combination chemotherapy with S-1 and low dose cisplatin against highly advanced gastric carcinoma

  • Authors:
    • Yoshiro Saikawa
    • Yoshikiyo Akasaka
    • Toshio Kanai
    • Yoshihide Otani
    • Koichiro Kumai
    • Tetsuro Kubota
    • Masaki Kitajima

  • View Affiliations

  • Published online on: March 1, 2003     https://doi.org/10.3892/or.10.2.381
  • Pages: 381-386
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Abstract

We performed preoperative chemotherapy with S-1 and low-dose CDDP (TSLD) to treat 9 patients of highly advanced gastric cancer. Five cases showed significant effect with severe fibrosis diagnosed as grade 1b-2 effect in histology, and all 9 cases showed at least grade 1a effect in either primary lesion or lymph node. While toxicity of less than grade 3 (gastrointestinal disorder and/or bone marrow suppression) were observed in 5 out of 9 cases (55.6%), no symptom was observed in 3 out of the 5 patients. We conclude that the TSLD is useful to control highly advanced gastric cancer.

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March-April 2003
Volume 10 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 4.2
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Saikawa Y, Akasaka Y, Kanai T, Otani Y, Kumai K, Kubota T and Kitajima M: Preoperative combination chemotherapy with S-1 and low dose cisplatin against highly advanced gastric carcinoma. Oncol Rep 10: 381-386, 2003
APA
Saikawa, Y., Akasaka, Y., Kanai, T., Otani, Y., Kumai, K., Kubota, T., & Kitajima, M. (2003). Preoperative combination chemotherapy with S-1 and low dose cisplatin against highly advanced gastric carcinoma. Oncology Reports, 10, 381-386. https://doi.org/10.3892/or.10.2.381
MLA
Saikawa, Y., Akasaka, Y., Kanai, T., Otani, Y., Kumai, K., Kubota, T., Kitajima, M."Preoperative combination chemotherapy with S-1 and low dose cisplatin against highly advanced gastric carcinoma". Oncology Reports 10.2 (2003): 381-386.
Chicago
Saikawa, Y., Akasaka, Y., Kanai, T., Otani, Y., Kumai, K., Kubota, T., Kitajima, M."Preoperative combination chemotherapy with S-1 and low dose cisplatin against highly advanced gastric carcinoma". Oncology Reports 10, no. 2 (2003): 381-386. https://doi.org/10.3892/or.10.2.381