Co-expression of receptor for advanced glycation end products and the ligand amphoterin associates closely with metastasis of colorectal cancer

  • Authors:
    • Hiroki Kuniyasu
    • Yoshitomo Chihara
    • Tadateru Takahashi
  • View Affiliations

  • Published online on: Saturday, March 1, 2003
  • Pages: 445-448 DOI: 10.3892/or.10.2.445

Abstract

The clinical relevance of the receptor for advanced glycation end products (RAGE) and amphoterin expression was examined in 119 non-diabetic patients with colorectal carcinoma. Expression of RAGE was examined by immunohistochemistry and that of amphoterin by in situ hybridization. RAGE expression was observed in 55% (64/119) of the cases. RAGE positivity in Dukes' B, C and D cases was 19, 81 and 100%, respectively (p<0.0001). Amphoterin was expressed in most cases regardless of tumor stage. Survival analysis of Dukes' B and C cases showed a significantly poorer prognosis for patients with co-expression of RAGE and amphoterin than for patients without co-expression. The results suggest that co-expression of RAGE and amphoterin is closely associated with invasion and metastasis of colorectal cancer.

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March 2003
Volume 10 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

2015 Impact Factor: 2.486
Ranked #31/211 Oncology
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APA
Kuniyasu, H., Chihara, Y., & Takahashi, T. (2003). Co-expression of receptor for advanced glycation end products and the ligand amphoterin associates closely with metastasis of colorectal cancer. Oncology Reports, 10, 445-448. http://dx.doi.org/10.3892/or.10.2.445
MLA
Kuniyasu, H., Chihara, Y., Takahashi, T."Co-expression of receptor for advanced glycation end products and the ligand amphoterin associates closely with metastasis of colorectal cancer". Oncology Reports 10.2 (2003): 445-448.
Chicago
Kuniyasu, H., Chihara, Y., Takahashi, T."Co-expression of receptor for advanced glycation end products and the ligand amphoterin associates closely with metastasis of colorectal cancer". Oncology Reports 10, no. 2 (2003): 445-448. http://dx.doi.org/10.3892/or.10.2.445