Epigenetic control of E-cadherin (CDH1) by CpG methylation in metastasising laryngeal cancer

  • Authors:
    • Pia Azarschab
    • Agnieszka Stembalska
    • Mirela Baus Loncar
    • Markus Pfister
    • Maria M. Sasiadek
    • Nikolaus Blin
  • View Affiliations

  • Published online on: March 1, 2003     https://doi.org/10.3892/or.10.2.501
  • Pages: 501-503
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Abstract

Intercellular adhesion is promoted by many-fold structures formed by interacting molecules. One prominent protein family, called cadherins, consists of calcium-dependent proteins contributing to cell differentiation, migration and extracellular signal transduction. E-cadherin, regularly expressed in epithelial tissues, displays aberrant activity patterns in a variety of tumors. We have explored the mode of E-cadherin regulation in 98 biopsy samples from 76 patients with laryngeal carcinoma (80 primary tumors and 18 metastases). Transcriptional silencing of the gene (CDH1) achieved by promoter methylation was tested by a methylation-specific PCR. In primary tumors, CDH1 methylation was noted in 40%. However, 77% of the tested metastases showed CDH1 methylation, 23% remained unmethylated (p<0.01). These data suggest that the E-cadherin promoter is subjected to epigenetic control connected with biological aggressiveness of laryngeal cancer in advanced steps of neoplastic transformation.

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March-April 2003
Volume 10 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Azarschab P, Stembalska A, Loncar MB, Pfister M, Sasiadek MM and Blin N: Epigenetic control of E-cadherin (CDH1) by CpG methylation in metastasising laryngeal cancer. Oncol Rep 10: 501-503, 2003.
APA
Azarschab, P., Stembalska, A., Loncar, M.B., Pfister, M., Sasiadek, M.M., & Blin, N. (2003). Epigenetic control of E-cadherin (CDH1) by CpG methylation in metastasising laryngeal cancer. Oncology Reports, 10, 501-503. https://doi.org/10.3892/or.10.2.501
MLA
Azarschab, P., Stembalska, A., Loncar, M. B., Pfister, M., Sasiadek, M. M., Blin, N."Epigenetic control of E-cadherin (CDH1) by CpG methylation in metastasising laryngeal cancer". Oncology Reports 10.2 (2003): 501-503.
Chicago
Azarschab, P., Stembalska, A., Loncar, M. B., Pfister, M., Sasiadek, M. M., Blin, N."Epigenetic control of E-cadherin (CDH1) by CpG methylation in metastasising laryngeal cancer". Oncology Reports 10, no. 2 (2003): 501-503. https://doi.org/10.3892/or.10.2.501