Mucinous cystic tumor of the pancreas: Immunohistochemical assessment of ‘ovarian-type stroma’

  • Authors:
    • Akihiko Izumo
    • Koji Yamaguchi
    • Takashi Eguchi
    • Kenichi Nishiyama
    • Hidetaka Yamamoto
    • Hirotoshi Yonemasu
    • Takashi Yao
    • Masao Tanaka
    • Masazumi Tsuneyoshi
  • View Affiliations

  • Published online on: May 1, 2003     https://doi.org/10.3892/or.10.3.515
  • Pages: 515-525
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Abstract

The new histopathological classification of exocrine pancreatic tumors by the World Health Organization, now includes ‘ovarian-type stroma’ (‘OS’) in the definition of mucinous cystic tumor of the pancreas (MCT-P). This study investigated the clinicopathological findings of the MCT-P according to WHO classification and scrutinize the function of ‘OS’ in MCT-P immunohistochemically. Thirty-four cases of MCT-P (28 adenomas, 2 borderline tumors and 4 adenocarcinomas) were examined clinicopathologically. The ‘OS’ of 34 MCTs-P were studied immunohistochemically and compared with the stroma of 10 mucinous cystic tumors of the ovary (MCTs-O), 10 conventional pancreatic carcinomas and 6 normal ovaries. Almost all 34 MCTs-P were located in the body-tail of the pancreas of middle-aged women. Histologically the ‘OS’ cells exhibited luteinization in 11/34 (32.4%). Immunohistochemically, both ‘OS’ cells and the stromal cells in MCT-O showed similar positivity rates; calponin (34/34 and 9/10), h-caldesmon (28/34 and 8/10), α-inhibin (29/34 and 9/10), estrogen-receptor (21/34 and 6/10) and progesterone-receptor (28/34 and 9/10, respectively). Some neoplastic epithelial cells of MCT-P were positive for human chorionic gonadotropin (hCG) (21/34, 61.8%). This study indicates the predominance of MCT in the distal pancreas of middle-aged women. Furthermore, the immunohistochemical and histological results demonstrate that the ‘OS’ of MCT-P and the stroma of MCT-O share the same characteristics. The results also suggested that the hCG produced by the neoplastic epithelium probably plays an important role in the luteinization of the stroma of MCT-P. We therefore conclude there is a possibility that MCT-P originates from the left remnant primordial gonadal cells which migrated to the pancreatic anlage during the early development of the fetus.

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May-June 2003
Volume 10 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Izumo A, Yamaguchi K, Eguchi T, Nishiyama K, Yamamoto H, Yonemasu H, Yao T, Tanaka M and Tsuneyoshi M: Mucinous cystic tumor of the pancreas: Immunohistochemical assessment of ‘ovarian-type stroma’. Oncol Rep 10: 515-525, 2003
APA
Izumo, A., Yamaguchi, K., Eguchi, T., Nishiyama, K., Yamamoto, H., Yonemasu, H. ... Tsuneyoshi, M. (2003). Mucinous cystic tumor of the pancreas: Immunohistochemical assessment of ‘ovarian-type stroma’. Oncology Reports, 10, 515-525. https://doi.org/10.3892/or.10.3.515
MLA
Izumo, A., Yamaguchi, K., Eguchi, T., Nishiyama, K., Yamamoto, H., Yonemasu, H., Yao, T., Tanaka, M., Tsuneyoshi, M."Mucinous cystic tumor of the pancreas: Immunohistochemical assessment of ‘ovarian-type stroma’". Oncology Reports 10.3 (2003): 515-525.
Chicago
Izumo, A., Yamaguchi, K., Eguchi, T., Nishiyama, K., Yamamoto, H., Yonemasu, H., Yao, T., Tanaka, M., Tsuneyoshi, M."Mucinous cystic tumor of the pancreas: Immunohistochemical assessment of ‘ovarian-type stroma’". Oncology Reports 10, no. 3 (2003): 515-525. https://doi.org/10.3892/or.10.3.515