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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May-June 2003 Volume 10 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Management of Merkel cell carcinoma: Case series of 36 patients

  • Authors:
    • Anja Müller
    • Ronald Keus
    • Norbert Neumann
    • Guido Lammering
    • Thomas Schnabel

  • View Affiliations / Copyright

    Affiliations: Department of Radiation Therapy and Radiation Oncology, Heinrich-Heine-University, D-40225 Dusseldorf, Germany. a.mueller@uni-duesseldorf.de
  • Pages: 577-585
    |
    Published online on: May 1, 2003
       https://doi.org/10.3892/or.10.3.577
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Abstract

Merkel cell carcinoma is a rare, highly malignant skin tumor with a predisposition for local, nodal and distant recurrence which should be managed in a multimodal approach. Here, we performed a retrospective analysis of 36 patients, treated from 1984 to 1994. In patients with stage I disease, locoregional recurrence after surgery alone occurred in 65% compared to 43% after excision and adjuvant radiotherapy. Although the difference in disease-specific survival was not significant (67% versus 52% at 5 years), combination therapy conferred a benefit for locoregional control and relapse-free survival (88 versus 58 months). The majority of failures (54%) occurred within the draining lymph nodes that were not treated in the initial approach and locoregional recurrence was strongly associated with a later systemic relapse (50% versus 0%). Salvage after localized recurrence was achieved in 67% of resectable cases. The high rate of nodal recurrence after surgery alone warrants the use of elective nodal treatment in patients with stage I disease. Surgical resection of the primary tumor should be followed by postoperative radiotherapy to the primary site and draining lymph nodes. Even after locoregional recurrence, a substantial proportion of patients is able to achieve long-term disease-free survival, particularly after complete resection and adjuvant irradiation.

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Copy and paste a formatted citation
Spandidos Publications style
Müller A, Keus R, Neumann N, Lammering G and Schnabel T: Management of Merkel cell carcinoma: Case series of 36 patients. Oncol Rep 10: 577-585, 2003.
APA
Müller, A., Keus, R., Neumann, N., Lammering, G., & Schnabel, T. (2003). Management of Merkel cell carcinoma: Case series of 36 patients. Oncology Reports, 10, 577-585. https://doi.org/10.3892/or.10.3.577
MLA
Müller, A., Keus, R., Neumann, N., Lammering, G., Schnabel, T."Management of Merkel cell carcinoma: Case series of 36 patients". Oncology Reports 10.3 (2003): 577-585.
Chicago
Müller, A., Keus, R., Neumann, N., Lammering, G., Schnabel, T."Management of Merkel cell carcinoma: Case series of 36 patients". Oncology Reports 10, no. 3 (2003): 577-585. https://doi.org/10.3892/or.10.3.577
Copy and paste a formatted citation
x
Spandidos Publications style
Müller A, Keus R, Neumann N, Lammering G and Schnabel T: Management of Merkel cell carcinoma: Case series of 36 patients. Oncol Rep 10: 577-585, 2003.
APA
Müller, A., Keus, R., Neumann, N., Lammering, G., & Schnabel, T. (2003). Management of Merkel cell carcinoma: Case series of 36 patients. Oncology Reports, 10, 577-585. https://doi.org/10.3892/or.10.3.577
MLA
Müller, A., Keus, R., Neumann, N., Lammering, G., Schnabel, T."Management of Merkel cell carcinoma: Case series of 36 patients". Oncology Reports 10.3 (2003): 577-585.
Chicago
Müller, A., Keus, R., Neumann, N., Lammering, G., Schnabel, T."Management of Merkel cell carcinoma: Case series of 36 patients". Oncology Reports 10, no. 3 (2003): 577-585. https://doi.org/10.3892/or.10.3.577
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