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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May-June 2003 Volume 10 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Expression and regulation patterns of hyaluronidases in small cell lung cancer and glioma lines

  • Authors:
    • Nanna Junker
    • Scilla Latini
    • Lone N. Petersen
    • Paul E.G. Kristjansen

  • View Affiliations / Copyright

    Affiliations: Laboratory of Experimental Oncology, Department of Molecular Pathology, University of Copenhagen, DK-2100 Copenhagen, Denmark
  • Pages: 609-616
    |
    Published online on: May 1, 2003
       https://doi.org/10.3892/or.10.3.609
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Abstract

Hyaluronan and hyaluronidases have been proposed to be involved in tumor angiogenesis and invasion. Three hyaluronidases, HYAL1, HYAL2 and HYAL3, are located at the chromosomal region 3p21. In most small cell lung cancer (SCLC) lines the 3p21 region is part of a homozygote or heterozygote deletion. Gliomas are known to exist in a hyaluronan rich environment and express high levels of the hyaluronan receptor CD44. In a panel of SCLC and glioma cell lines the expression of HYAL1, HYAL2 and HYAL3 mRNA was examined. It was observed that the cell lines differed in their ability to splice out a retained intron in the 5' UTR of HYAL1 mRNA. A correlation seems to exist between the ability to splice out the retained 5' end intron of HYAL1 mRNA and the general hyaluronidase activity. In one cell line a substantial part of the hyaluronidase activity was abolished by immunoprecipitation of Hyal1, which strongly indicates that Hyal1 is the principal hyaluornidase in the examined cell lines. During severe hypoxia a significant reduction in both hyaluronidase mRNA and protein activity was found. These results support the theory of involvement of hyaluronidase in the angiogenic and invasive front of tumors.

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Copy and paste a formatted citation
Spandidos Publications style
Junker N, Latini S, Petersen LN and Kristjansen PE: Expression and regulation patterns of hyaluronidases in small cell lung cancer and glioma lines. Oncol Rep 10: 609-616, 2003.
APA
Junker, N., Latini, S., Petersen, L.N., & Kristjansen, P.E. (2003). Expression and regulation patterns of hyaluronidases in small cell lung cancer and glioma lines. Oncology Reports, 10, 609-616. https://doi.org/10.3892/or.10.3.609
MLA
Junker, N., Latini, S., Petersen, L. N., Kristjansen, P. E."Expression and regulation patterns of hyaluronidases in small cell lung cancer and glioma lines". Oncology Reports 10.3 (2003): 609-616.
Chicago
Junker, N., Latini, S., Petersen, L. N., Kristjansen, P. E."Expression and regulation patterns of hyaluronidases in small cell lung cancer and glioma lines". Oncology Reports 10, no. 3 (2003): 609-616. https://doi.org/10.3892/or.10.3.609
Copy and paste a formatted citation
x
Spandidos Publications style
Junker N, Latini S, Petersen LN and Kristjansen PE: Expression and regulation patterns of hyaluronidases in small cell lung cancer and glioma lines. Oncol Rep 10: 609-616, 2003.
APA
Junker, N., Latini, S., Petersen, L.N., & Kristjansen, P.E. (2003). Expression and regulation patterns of hyaluronidases in small cell lung cancer and glioma lines. Oncology Reports, 10, 609-616. https://doi.org/10.3892/or.10.3.609
MLA
Junker, N., Latini, S., Petersen, L. N., Kristjansen, P. E."Expression and regulation patterns of hyaluronidases in small cell lung cancer and glioma lines". Oncology Reports 10.3 (2003): 609-616.
Chicago
Junker, N., Latini, S., Petersen, L. N., Kristjansen, P. E."Expression and regulation patterns of hyaluronidases in small cell lung cancer and glioma lines". Oncology Reports 10, no. 3 (2003): 609-616. https://doi.org/10.3892/or.10.3.609
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