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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May-June 2003 Volume 10 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Continuous increase in phosphorylation of cytosolic thymidine kinase during proliferation of rat hepatoma JB1 cells

  • Authors:
    • Ling Lin
    • Namiko Kuroiwa
    • Yuichi Moriyama
    • Shinji Fujimura

  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, Chiba University School of Medicine, Chuo-ku, Chiba 260-8670, Japan. linling18@hotmail.com
  • Pages: 665-669
    |
    Published online on: May 1, 2003
       https://doi.org/10.3892/or.10.3.665
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Abstract

Thymidine kinase (TK) is a protein closely associated with DNA replication. Here we show that, in contrast with the variation of TK activity, which changed parallel with S phase cell distribution during asynchronous culture of rat hepatoma JB1 cells, the serine residues of cytosolic TK protein was phosphorylated continuously in response to increasing G0/G1 phase cell distribution. The shifting of phosphorylation of TK protein during different cell growth conditions was further confirmed with the examination of the elution profile of cytosolic TK activity by anion-exchange high performance liquid chromatography (HPLC). HPLC analysis revealed that the rapid proliferating (62 h after asynchronous culture) rat hepatoma JB1 cells showed only the hyperphosphorylated form of cytosolic TK activity, while synchronously M phase-arrested JB1 cells showed hypo- and hyper-phosphorylated forms of cytosolic TK activity. These results suggested that the modulation of phosphorylation of cytosolic TK protein was cell cycle-dependent, and that the phosphorylation of cytosolic TK protein might be involved in the negative regulation of TK activity in vivo.

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Copy and paste a formatted citation
Spandidos Publications style
Lin L, Kuroiwa N, Moriyama Y and Fujimura S: Continuous increase in phosphorylation of cytosolic thymidine kinase during proliferation of rat hepatoma JB1 cells. Oncol Rep 10: 665-669, 2003.
APA
Lin, L., Kuroiwa, N., Moriyama, Y., & Fujimura, S. (2003). Continuous increase in phosphorylation of cytosolic thymidine kinase during proliferation of rat hepatoma JB1 cells. Oncology Reports, 10, 665-669. https://doi.org/10.3892/or.10.3.665
MLA
Lin, L., Kuroiwa, N., Moriyama, Y., Fujimura, S."Continuous increase in phosphorylation of cytosolic thymidine kinase during proliferation of rat hepatoma JB1 cells". Oncology Reports 10.3 (2003): 665-669.
Chicago
Lin, L., Kuroiwa, N., Moriyama, Y., Fujimura, S."Continuous increase in phosphorylation of cytosolic thymidine kinase during proliferation of rat hepatoma JB1 cells". Oncology Reports 10, no. 3 (2003): 665-669. https://doi.org/10.3892/or.10.3.665
Copy and paste a formatted citation
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Spandidos Publications style
Lin L, Kuroiwa N, Moriyama Y and Fujimura S: Continuous increase in phosphorylation of cytosolic thymidine kinase during proliferation of rat hepatoma JB1 cells. Oncol Rep 10: 665-669, 2003.
APA
Lin, L., Kuroiwa, N., Moriyama, Y., & Fujimura, S. (2003). Continuous increase in phosphorylation of cytosolic thymidine kinase during proliferation of rat hepatoma JB1 cells. Oncology Reports, 10, 665-669. https://doi.org/10.3892/or.10.3.665
MLA
Lin, L., Kuroiwa, N., Moriyama, Y., Fujimura, S."Continuous increase in phosphorylation of cytosolic thymidine kinase during proliferation of rat hepatoma JB1 cells". Oncology Reports 10.3 (2003): 665-669.
Chicago
Lin, L., Kuroiwa, N., Moriyama, Y., Fujimura, S."Continuous increase in phosphorylation of cytosolic thymidine kinase during proliferation of rat hepatoma JB1 cells". Oncology Reports 10, no. 3 (2003): 665-669. https://doi.org/10.3892/or.10.3.665
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