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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July-August 2003 Volume 10 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Frequent death-associated protein-kinase promoter hypermethylation in brain metastases of solid tumors

  • Authors:
    • Pilar Gonzalez-Gomez
    • M. Josefa Bello
    • M. Eva Alonso
    • Jesus Lomas
    • Dolores Arjona
    • Cinthia Amiñoso
    • Jose M. De Campos
    • Alberto Isla
    • Manuel Gutierrez
    • Juan A. Rey

  • View Affiliations / Copyright

    Affiliations: Laboratorio de Oncogenetica Molecular, Department C. Experimental, Hospital Universitario La Paz, 28046 Madrid, Spain
  • Pages: 1031-1033
    |
    Published online on: July 1, 2003
       https://doi.org/10.3892/or.10.4.1031
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Abstract

Death-associated protein (DAP) kinase is a gene that participates in apoptosis induced by interferon γ. It appears to play a role in lung cancer metastasis in animal models, suggesting that DAP-kinase may function as a metastasis suppressor by inducing apoptosis. Expression silencing through CpG island methylation of DAP-kinase has been frequently found in connection with adverse survival, as cells lacking DAP-kinase appear to be more invasive and more metastatic in lung cancer. The purpose of this study was to analyze the promoter methylation status of DAP-kinase gene in brain metastases of solid tumors. Methylation-specific PCR was performed on ten brain metastasis samples derived from malignant melanoma (three cases), lung cancer (two), breast carcinoma (two), ovarian carcinoma (two) and colon carcinoma (one case), and in corresponding peripheral blood DNA samples. Two normal brain tissue samples were also analyzed, no promoter hypermethylation was observed in either case. DAP-kinase hypermethylated alleles were identified in nine metastases (90%), and in peripheral blood lymphocytes DNA from four cases. Our data suggest that silencing of DAP-kinase through promoter hypermethylation is a common event in the multistep process of tumor metastasis, including brain involvement.

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Copy and paste a formatted citation
Spandidos Publications style
Gonzalez-Gomez P, Bello MJ, Alonso ME, Lomas J, Arjona D, Amiñoso C, De Campos JM, Isla A, Gutierrez M, Rey JA, Rey JA, et al: Frequent death-associated protein-kinase promoter hypermethylation in brain metastases of solid tumors. Oncol Rep 10: 1031-1033, 2003.
APA
Gonzalez-Gomez, P., Bello, M.J., Alonso, M.E., Lomas, J., Arjona, D., Amiñoso, C. ... Rey, J.A. (2003). Frequent death-associated protein-kinase promoter hypermethylation in brain metastases of solid tumors. Oncology Reports, 10, 1031-1033. https://doi.org/10.3892/or.10.4.1031
MLA
Gonzalez-Gomez, P., Bello, M. J., Alonso, M. E., Lomas, J., Arjona, D., Amiñoso, C., De Campos, J. M., Isla, A., Gutierrez, M., Rey, J. A."Frequent death-associated protein-kinase promoter hypermethylation in brain metastases of solid tumors". Oncology Reports 10.4 (2003): 1031-1033.
Chicago
Gonzalez-Gomez, P., Bello, M. J., Alonso, M. E., Lomas, J., Arjona, D., Amiñoso, C., De Campos, J. M., Isla, A., Gutierrez, M., Rey, J. A."Frequent death-associated protein-kinase promoter hypermethylation in brain metastases of solid tumors". Oncology Reports 10, no. 4 (2003): 1031-1033. https://doi.org/10.3892/or.10.4.1031
Copy and paste a formatted citation
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Spandidos Publications style
Gonzalez-Gomez P, Bello MJ, Alonso ME, Lomas J, Arjona D, Amiñoso C, De Campos JM, Isla A, Gutierrez M, Rey JA, Rey JA, et al: Frequent death-associated protein-kinase promoter hypermethylation in brain metastases of solid tumors. Oncol Rep 10: 1031-1033, 2003.
APA
Gonzalez-Gomez, P., Bello, M.J., Alonso, M.E., Lomas, J., Arjona, D., Amiñoso, C. ... Rey, J.A. (2003). Frequent death-associated protein-kinase promoter hypermethylation in brain metastases of solid tumors. Oncology Reports, 10, 1031-1033. https://doi.org/10.3892/or.10.4.1031
MLA
Gonzalez-Gomez, P., Bello, M. J., Alonso, M. E., Lomas, J., Arjona, D., Amiñoso, C., De Campos, J. M., Isla, A., Gutierrez, M., Rey, J. A."Frequent death-associated protein-kinase promoter hypermethylation in brain metastases of solid tumors". Oncology Reports 10.4 (2003): 1031-1033.
Chicago
Gonzalez-Gomez, P., Bello, M. J., Alonso, M. E., Lomas, J., Arjona, D., Amiñoso, C., De Campos, J. M., Isla, A., Gutierrez, M., Rey, J. A."Frequent death-associated protein-kinase promoter hypermethylation in brain metastases of solid tumors". Oncology Reports 10, no. 4 (2003): 1031-1033. https://doi.org/10.3892/or.10.4.1031
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