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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July-August 2003 Volume 10 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Expression status of Pin1 and cyclins in oral squamous cell carcinoma: Pin1 correlates with Cyclin D1 mRNA expression and clinical significance of cyclins

  • Authors:
    • Hitoshi Miyashita
    • Takafumi Uchida
    • Shiro Mori
    • Seishi Echigo
    • Katutoshi Motegi

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Institute of Development, Aging and Cancer, Sendai, Japan
  • Pages: 1045-1048
    |
    Published online on: July 1, 2003
       https://doi.org/10.3892/or.10.4.1045
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Abstract

Phosphorylation on serine or threonine residue preceding proline (Ser/Thr-Pro) is a key regulatory mechanism. The conformation of certain phosphorylated Ser/Thr-Pro bonds is regulated specifically by the prolyl isomerase Pin1. It has been reported that Pin1 is strikingly overexpressed in a subset of human tumors. A differential-display screen reveals that Pin1 increases the transcription of several β-catenin target genes, including those encoding cyclin D1 and c-Myc. Pin1 cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1. We have previously reported that Pin1 is overexpressed in oral squamous cell carcinoma (OSCC) and its level correlates with Cyclin D1 expression. However, the analysis of the relationship between Pin1 and other cyclin genes has not been demonstrated in human OSCC. We examined Pin1 mRNA and protein expressions in OSCC cell lines, and analyzed Pin1/cyclins expression by RT-PCR. We report that Pin1 mRNA correlates with Cyclin D1 mRNA expression and the expression of many cyclin genes is associated with lymph node metastasis in OSCC. These results indicate that Pin1 is a regulator of Cyclin D1 expression in OSCC and might have a role in oncogenesis; and the expression of many cyclin genes will be an indicator of lymph node metastasis in OSCC.

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Copy and paste a formatted citation
Spandidos Publications style
Miyashita H, Uchida T, Mori S, Echigo S and Motegi K: Expression status of Pin1 and cyclins in oral squamous cell carcinoma: Pin1 correlates with Cyclin D1 mRNA expression and clinical significance of cyclins. Oncol Rep 10: 1045-1048, 2003.
APA
Miyashita, H., Uchida, T., Mori, S., Echigo, S., & Motegi, K. (2003). Expression status of Pin1 and cyclins in oral squamous cell carcinoma: Pin1 correlates with Cyclin D1 mRNA expression and clinical significance of cyclins. Oncology Reports, 10, 1045-1048. https://doi.org/10.3892/or.10.4.1045
MLA
Miyashita, H., Uchida, T., Mori, S., Echigo, S., Motegi, K."Expression status of Pin1 and cyclins in oral squamous cell carcinoma: Pin1 correlates with Cyclin D1 mRNA expression and clinical significance of cyclins". Oncology Reports 10.4 (2003): 1045-1048.
Chicago
Miyashita, H., Uchida, T., Mori, S., Echigo, S., Motegi, K."Expression status of Pin1 and cyclins in oral squamous cell carcinoma: Pin1 correlates with Cyclin D1 mRNA expression and clinical significance of cyclins". Oncology Reports 10, no. 4 (2003): 1045-1048. https://doi.org/10.3892/or.10.4.1045
Copy and paste a formatted citation
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Spandidos Publications style
Miyashita H, Uchida T, Mori S, Echigo S and Motegi K: Expression status of Pin1 and cyclins in oral squamous cell carcinoma: Pin1 correlates with Cyclin D1 mRNA expression and clinical significance of cyclins. Oncol Rep 10: 1045-1048, 2003.
APA
Miyashita, H., Uchida, T., Mori, S., Echigo, S., & Motegi, K. (2003). Expression status of Pin1 and cyclins in oral squamous cell carcinoma: Pin1 correlates with Cyclin D1 mRNA expression and clinical significance of cyclins. Oncology Reports, 10, 1045-1048. https://doi.org/10.3892/or.10.4.1045
MLA
Miyashita, H., Uchida, T., Mori, S., Echigo, S., Motegi, K."Expression status of Pin1 and cyclins in oral squamous cell carcinoma: Pin1 correlates with Cyclin D1 mRNA expression and clinical significance of cyclins". Oncology Reports 10.4 (2003): 1045-1048.
Chicago
Miyashita, H., Uchida, T., Mori, S., Echigo, S., Motegi, K."Expression status of Pin1 and cyclins in oral squamous cell carcinoma: Pin1 correlates with Cyclin D1 mRNA expression and clinical significance of cyclins". Oncology Reports 10, no. 4 (2003): 1045-1048. https://doi.org/10.3892/or.10.4.1045
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