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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July-August 2003 Volume 10 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Hypoxia-inducible factor-1α expression and angiogenesis in gastrointestinal stromal tumor of the stomach

  • Authors:
    • Ryoji Takahashi
    • Shinji Tanaka
    • Toru Hiyama
    • Masanori Ito
    • Yasuhiko Kitadai
    • Masaharu Sumii
    • Ken Haruma
    • Kazuaki Chayama

  • View Affiliations / Copyright

    Affiliations: Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan
  • Pages: 797-802
    |
    Published online on: July 1, 2003
       https://doi.org/10.3892/or.10.4.797
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Abstract

Hypoxia inducible factor (HIF)-1 is reported to transactivate expression of vascular endothelial growth factor (VEGF), which is an important angiogenic factor. The aim of this study was to elucidate the clinical significance of HIF-1α expression in gastrointestinal stromal tumors (GIST). Specimens obtained from 53 patients who underwent surgical resection for GIST of the stomach were used in this study. Specimens were examined immunohistochemically for HIF-1α, VEGF, and Ki-67 expression. Tumor microvessel density (MVD) was determined immunohistochemically with anti-CD31 antibody and was estimated by averaging the counts from three high-power fields in the area showing the greatest neovascularization. HIF-1α expression was detected in 17 (32.1%) of 53 lesions and was correlated significantly with tumor size, liver metastasis, VEGF expression, and MVD. Prognosis was significantly poorer in patients with tumors expressing HIF-1α than in patients with tumors lacking HIF-1α expression. HIF-1α may play a role in angiogenesis and tumor progression of GIST through regulation of VEGF.

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Copy and paste a formatted citation
Spandidos Publications style
Takahashi R, Tanaka S, Hiyama T, Ito M, Kitadai Y, Sumii M, Haruma K and Chayama K: Hypoxia-inducible factor-1α expression and angiogenesis in gastrointestinal stromal tumor of the stomach. Oncol Rep 10: 797-802, 2003.
APA
Takahashi, R., Tanaka, S., Hiyama, T., Ito, M., Kitadai, Y., Sumii, M. ... Chayama, K. (2003). Hypoxia-inducible factor-1α expression and angiogenesis in gastrointestinal stromal tumor of the stomach. Oncology Reports, 10, 797-802. https://doi.org/10.3892/or.10.4.797
MLA
Takahashi, R., Tanaka, S., Hiyama, T., Ito, M., Kitadai, Y., Sumii, M., Haruma, K., Chayama, K."Hypoxia-inducible factor-1α expression and angiogenesis in gastrointestinal stromal tumor of the stomach". Oncology Reports 10.4 (2003): 797-802.
Chicago
Takahashi, R., Tanaka, S., Hiyama, T., Ito, M., Kitadai, Y., Sumii, M., Haruma, K., Chayama, K."Hypoxia-inducible factor-1α expression and angiogenesis in gastrointestinal stromal tumor of the stomach". Oncology Reports 10, no. 4 (2003): 797-802. https://doi.org/10.3892/or.10.4.797
Copy and paste a formatted citation
x
Spandidos Publications style
Takahashi R, Tanaka S, Hiyama T, Ito M, Kitadai Y, Sumii M, Haruma K and Chayama K: Hypoxia-inducible factor-1α expression and angiogenesis in gastrointestinal stromal tumor of the stomach. Oncol Rep 10: 797-802, 2003.
APA
Takahashi, R., Tanaka, S., Hiyama, T., Ito, M., Kitadai, Y., Sumii, M. ... Chayama, K. (2003). Hypoxia-inducible factor-1α expression and angiogenesis in gastrointestinal stromal tumor of the stomach. Oncology Reports, 10, 797-802. https://doi.org/10.3892/or.10.4.797
MLA
Takahashi, R., Tanaka, S., Hiyama, T., Ito, M., Kitadai, Y., Sumii, M., Haruma, K., Chayama, K."Hypoxia-inducible factor-1α expression and angiogenesis in gastrointestinal stromal tumor of the stomach". Oncology Reports 10.4 (2003): 797-802.
Chicago
Takahashi, R., Tanaka, S., Hiyama, T., Ito, M., Kitadai, Y., Sumii, M., Haruma, K., Chayama, K."Hypoxia-inducible factor-1α expression and angiogenesis in gastrointestinal stromal tumor of the stomach". Oncology Reports 10, no. 4 (2003): 797-802. https://doi.org/10.3892/or.10.4.797
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