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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July-August 2003 Volume 10 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July-August 2003 Volume 10 Issue 4

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Article

The stability of dihydropyrimidine dehydrogenase activity in colorectal cancer tissue after resection

  • Authors:
    • Sotaro Sadahiro
    • Toshiyuki Suzuki
    • Kenji Ishikawa
    • Tomoki Nakamura
    • Akemi Kamijo
    • Takeshi Saguchi
    • Seiei Yasuda
    • Tomoo Tajima
    • Hiroyasu Makuuchi
    • Chieko Murayama

  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Tokai University School of Medicine, Kanagawa 259-1193, Japan. sadahiro@is.icc.u-tokai.ac.jp
  • Pages: 867-869
    |
    Published online on: July 1, 2003
       https://doi.org/10.3892/or.10.4.867
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Abstract

Dihydropyrimidine dehydrogenase (DPD) is the first and rate-limiting enzyme in the catabolism of 5-fluorouracil (5-FU). DPD activity in tumor tissue may consequently serve as a predictive factor for sensitivity to 5-FU. The purpose of this study was to elucidate the stability of DPD activity over time in resected colorectal cancer tissue. DPD activity was measured in samples frozen immediately after the tumor was resected and in samples that had been allowed to stand at room temperature for 15, 30, 60, 120, and 180 min before being frozen. Surgical specimens obtained from 15 cases with advanced colorectal cancer were analyzed. The effects of differences among individuals and differences in time between collection and freezing were assessed by two-way analysis of variance (ANOVA). Significant differences in DPD activity were found among tumors (p=0.001), but there were no significant differences in the same tumor depending on the time between collection and freezing (p=0.496). Based on these results, it appears possible to make comparative assessments of DPD activity in colorectal cancer tissue without strictly stipulating the time between resection and freezing.

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Copy and paste a formatted citation
Spandidos Publications style
Sadahiro S, Suzuki T, Ishikawa K, Nakamura T, Kamijo A, Saguchi T, Yasuda S, Tajima T, Makuuchi H, Murayama C, Murayama C, et al: The stability of dihydropyrimidine dehydrogenase activity in colorectal cancer tissue after resection. Oncol Rep 10: 867-869, 2003.
APA
Sadahiro, S., Suzuki, T., Ishikawa, K., Nakamura, T., Kamijo, A., Saguchi, T. ... Murayama, C. (2003). The stability of dihydropyrimidine dehydrogenase activity in colorectal cancer tissue after resection. Oncology Reports, 10, 867-869. https://doi.org/10.3892/or.10.4.867
MLA
Sadahiro, S., Suzuki, T., Ishikawa, K., Nakamura, T., Kamijo, A., Saguchi, T., Yasuda, S., Tajima, T., Makuuchi, H., Murayama, C."The stability of dihydropyrimidine dehydrogenase activity in colorectal cancer tissue after resection". Oncology Reports 10.4 (2003): 867-869.
Chicago
Sadahiro, S., Suzuki, T., Ishikawa, K., Nakamura, T., Kamijo, A., Saguchi, T., Yasuda, S., Tajima, T., Makuuchi, H., Murayama, C."The stability of dihydropyrimidine dehydrogenase activity in colorectal cancer tissue after resection". Oncology Reports 10, no. 4 (2003): 867-869. https://doi.org/10.3892/or.10.4.867
Copy and paste a formatted citation
x
Spandidos Publications style
Sadahiro S, Suzuki T, Ishikawa K, Nakamura T, Kamijo A, Saguchi T, Yasuda S, Tajima T, Makuuchi H, Murayama C, Murayama C, et al: The stability of dihydropyrimidine dehydrogenase activity in colorectal cancer tissue after resection. Oncol Rep 10: 867-869, 2003.
APA
Sadahiro, S., Suzuki, T., Ishikawa, K., Nakamura, T., Kamijo, A., Saguchi, T. ... Murayama, C. (2003). The stability of dihydropyrimidine dehydrogenase activity in colorectal cancer tissue after resection. Oncology Reports, 10, 867-869. https://doi.org/10.3892/or.10.4.867
MLA
Sadahiro, S., Suzuki, T., Ishikawa, K., Nakamura, T., Kamijo, A., Saguchi, T., Yasuda, S., Tajima, T., Makuuchi, H., Murayama, C."The stability of dihydropyrimidine dehydrogenase activity in colorectal cancer tissue after resection". Oncology Reports 10.4 (2003): 867-869.
Chicago
Sadahiro, S., Suzuki, T., Ishikawa, K., Nakamura, T., Kamijo, A., Saguchi, T., Yasuda, S., Tajima, T., Makuuchi, H., Murayama, C."The stability of dihydropyrimidine dehydrogenase activity in colorectal cancer tissue after resection". Oncology Reports 10, no. 4 (2003): 867-869. https://doi.org/10.3892/or.10.4.867
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