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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July-August 2003 Volume 10 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

The site of injection of tumor cells in rats does not influence the subsequent distribution of metastases

  • Authors:
    • Dolores C. García-Olmo
    • María García-Rivas
    • Damián García-Olmo
    • Jesús Ontañón

  • View Affiliations / Copyright

    Affiliations: Unidad de Investigación, Complejo Hospitalario de Albacete, S-02006 Albacete, Spain. logol@chospab.es
  • Pages: 903-907
    |
    Published online on: July 1, 2003
       https://doi.org/10.3892/or.10.4.903
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Abstract

Our goal was to examine the influence of circulatory anatomy on the development of metastases. We compared the dissemination of tumor cells to different tissues at different stages in both an orthotopic and a heterotopic model of colon cancer in the rat. We used DHD/K12-PROb cells and two groups of BD-IX rats: group O (orthotopic), in which tumors were implanted by intramural injection of the cecum; and group H (heterotopic), in which cells were injected subcutaneously into the thoracic wall. Animals were assigned randomly to one of nine subgroups of each group in terms of the time between the injection of cells and euthanasia (from the third to the twelfth week). The presence of lung or liver macrometastases was recorded and tumor DNA was detected in lung and liver samples from all animals. We found that lung metastases developed in rats in groups O and H, but no metastases were found in liver parenchymas. The rates of detection of tumor DNA in lung and in liver samples were similar in the two groups. Our results suggest that the site of inoculation of DHD/K12-PROb cells did not influence the pattern of development of metastases. This does not support the proposed role of the circulatory anatomy in the distribution of metastases.

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Copy and paste a formatted citation
Spandidos Publications style
García-Olmo DC, García-Rivas M, García-Olmo D and Ontañón J: The site of injection of tumor cells in rats does not influence the subsequent distribution of metastases. Oncol Rep 10: 903-907, 2003.
APA
García-Olmo, D.C., García-Rivas, M., García-Olmo, D., & Ontañón, J. (2003). The site of injection of tumor cells in rats does not influence the subsequent distribution of metastases. Oncology Reports, 10, 903-907. https://doi.org/10.3892/or.10.4.903
MLA
García-Olmo, D. C., García-Rivas, M., García-Olmo, D., Ontañón, J."The site of injection of tumor cells in rats does not influence the subsequent distribution of metastases". Oncology Reports 10.4 (2003): 903-907.
Chicago
García-Olmo, D. C., García-Rivas, M., García-Olmo, D., Ontañón, J."The site of injection of tumor cells in rats does not influence the subsequent distribution of metastases". Oncology Reports 10, no. 4 (2003): 903-907. https://doi.org/10.3892/or.10.4.903
Copy and paste a formatted citation
x
Spandidos Publications style
García-Olmo DC, García-Rivas M, García-Olmo D and Ontañón J: The site of injection of tumor cells in rats does not influence the subsequent distribution of metastases. Oncol Rep 10: 903-907, 2003.
APA
García-Olmo, D.C., García-Rivas, M., García-Olmo, D., & Ontañón, J. (2003). The site of injection of tumor cells in rats does not influence the subsequent distribution of metastases. Oncology Reports, 10, 903-907. https://doi.org/10.3892/or.10.4.903
MLA
García-Olmo, D. C., García-Rivas, M., García-Olmo, D., Ontañón, J."The site of injection of tumor cells in rats does not influence the subsequent distribution of metastases". Oncology Reports 10.4 (2003): 903-907.
Chicago
García-Olmo, D. C., García-Rivas, M., García-Olmo, D., Ontañón, J."The site of injection of tumor cells in rats does not influence the subsequent distribution of metastases". Oncology Reports 10, no. 4 (2003): 903-907. https://doi.org/10.3892/or.10.4.903
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