Correlation between occult neoplastic cells in the lymph node sinuses and recurrence in patients with curatively resected Dukes' B colorectal cancer

  • Authors:
    • Masaya Mukai
    • Shinkichi Sato
    • Nobukazu Komatsu
    • Tomomi Nishida
    • Kazuaki Shiba
    • Isao Ito
    • Hisao Nakasaki
    • Hiroyasu Makuuchi
  • View Affiliations

  • Published online on: September 1, 2003     https://doi.org/10.3892/or.10.5.1177
  • Pages: 1177-1181
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Abstract

This study investigated whether it is possible to detect patients who have a high risk of metastasis and recurrence after resection of stage II Dukes' B primary colorectal cancer. Among 434 patients who underwent curative resection of primary colorectal cancer, 167 (38.5%) had Dukes' B cancer. Among them, 19 patients (11.4%) suffered from postoperative metastasis or recurrence. In 17 patients with recurrence who could be followed-up completely (recurrence group) and 17 other patients who survived for at least 5 years without recurrence (non-recurrence group), immunohistochemical staining of resected lymph nodes for cytokeratin (AE1/AE3 and CAM 5.2) was performed. AE1/AE3 was positive in 76.5% and 47.1% of the patients from the recurrence and non-recurrence groups, respectively, while CAM 5.2 was positive in 52.9% and 17.6%, respectively. There were no significant differences of either AE1/AE3 or CAM 5.2 positivity between the groups. However, the occult neoplastic cell count (mean ± SD) floating in the lymph node sinuses was significantly higher in patients from the recurrence group who were positive for AE1/AE3 or CAM 5.2 than in patients from the non-recurrence group (6.12±6.00 vs. 0.59±0.71; p=0.0019 and 3.94±5.06 vs. 0.29±0.69; p=0.0098, respectively). These results suggest that patients with Dukes' B primary colorectal cancer who have a higher risk of recurrence can be selected by immunostaining of resected lymph nodes for cytokeratin.

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September-October 2003
Volume 10 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Mukai M, Sato S, Komatsu N, Nishida T, Shiba K, Ito I, Nakasaki H and Makuuchi H: Correlation between occult neoplastic cells in the lymph node sinuses and recurrence in patients with curatively resected Dukes' B colorectal cancer. Oncol Rep 10: 1177-1181, 2003
APA
Mukai, M., Sato, S., Komatsu, N., Nishida, T., Shiba, K., Ito, I. ... Makuuchi, H. (2003). Correlation between occult neoplastic cells in the lymph node sinuses and recurrence in patients with curatively resected Dukes' B colorectal cancer. Oncology Reports, 10, 1177-1181. https://doi.org/10.3892/or.10.5.1177
MLA
Mukai, M., Sato, S., Komatsu, N., Nishida, T., Shiba, K., Ito, I., Nakasaki, H., Makuuchi, H."Correlation between occult neoplastic cells in the lymph node sinuses and recurrence in patients with curatively resected Dukes' B colorectal cancer". Oncology Reports 10.5 (2003): 1177-1181.
Chicago
Mukai, M., Sato, S., Komatsu, N., Nishida, T., Shiba, K., Ito, I., Nakasaki, H., Makuuchi, H."Correlation between occult neoplastic cells in the lymph node sinuses and recurrence in patients with curatively resected Dukes' B colorectal cancer". Oncology Reports 10, no. 5 (2003): 1177-1181. https://doi.org/10.3892/or.10.5.1177