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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September-October 2003 Volume 10 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September-October 2003 Volume 10 Issue 5

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Article

Mutation analysis of CTNNB1 (β-catenin) and AXIN1, the components of Wnt pathway, in cervical carcinomas

  • Authors:
    • Tsung-Hsien Su
    • Jan-Gowth Chang
    • Kun-Tu Yeh
    • Ting-Hsu Lin
    • Tai-Ping Lee
    • Jui-Chang Chen
    • Cheng-Chieh Lin

  • View Affiliations / Copyright

    Affiliations: Department of Molecular Medicine, China Medical College Hospital, Taichung, Taiwan
  • Pages: 1195-1200
    |
    Published online on: September 1, 2003
       https://doi.org/10.3892/or.10.5.1195
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Abstract

The components of the Wnt-signaling pathway are mutated in tumors, but the relationship between these components and cervical cancer has not been elucidated. In this study, we used immunohistochemistry, single strand confirmation polymorphism (SSCP) and direct sequencing methods to analyze the mutation and protein expressions of both CTNNB1 and AXIN1 in cervical cancer. Among the 30 tested cervical cancers, no mutation of CTNNB1 but 3 polymorphisms were found. Mutation analysis of AXIN1 revealed that one specimen had a heterozygous mutation at codon 740 (GCC↷ACC) and six polymorphisms were also found. Immunohistochemistry showed no relationship between the protein expression patterns and mutation of AXIN1 and CTNNB1. Mutations of CTNNB1 may not be a factor, whereas mutations of AXIN1 may play a limited role in tumorigenesis of cervical cancer. In addition, aberrant expression patterns are not mutation related, so that other factors may be responsible for these changes.

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Copy and paste a formatted citation
Spandidos Publications style
Su T, Chang J, Yeh K, Lin T, Lee T, Chen J and Lin C: Mutation analysis of CTNNB1 (β-catenin) and AXIN1, the components of Wnt pathway, in cervical carcinomas. Oncol Rep 10: 1195-1200, 2003.
APA
Su, T., Chang, J., Yeh, K., Lin, T., Lee, T., Chen, J., & Lin, C. (2003). Mutation analysis of CTNNB1 (β-catenin) and AXIN1, the components of Wnt pathway, in cervical carcinomas. Oncology Reports, 10, 1195-1200. https://doi.org/10.3892/or.10.5.1195
MLA
Su, T., Chang, J., Yeh, K., Lin, T., Lee, T., Chen, J., Lin, C."Mutation analysis of CTNNB1 (β-catenin) and AXIN1, the components of Wnt pathway, in cervical carcinomas". Oncology Reports 10.5 (2003): 1195-1200.
Chicago
Su, T., Chang, J., Yeh, K., Lin, T., Lee, T., Chen, J., Lin, C."Mutation analysis of CTNNB1 (β-catenin) and AXIN1, the components of Wnt pathway, in cervical carcinomas". Oncology Reports 10, no. 5 (2003): 1195-1200. https://doi.org/10.3892/or.10.5.1195
Copy and paste a formatted citation
x
Spandidos Publications style
Su T, Chang J, Yeh K, Lin T, Lee T, Chen J and Lin C: Mutation analysis of CTNNB1 (β-catenin) and AXIN1, the components of Wnt pathway, in cervical carcinomas. Oncol Rep 10: 1195-1200, 2003.
APA
Su, T., Chang, J., Yeh, K., Lin, T., Lee, T., Chen, J., & Lin, C. (2003). Mutation analysis of CTNNB1 (β-catenin) and AXIN1, the components of Wnt pathway, in cervical carcinomas. Oncology Reports, 10, 1195-1200. https://doi.org/10.3892/or.10.5.1195
MLA
Su, T., Chang, J., Yeh, K., Lin, T., Lee, T., Chen, J., Lin, C."Mutation analysis of CTNNB1 (β-catenin) and AXIN1, the components of Wnt pathway, in cervical carcinomas". Oncology Reports 10.5 (2003): 1195-1200.
Chicago
Su, T., Chang, J., Yeh, K., Lin, T., Lee, T., Chen, J., Lin, C."Mutation analysis of CTNNB1 (β-catenin) and AXIN1, the components of Wnt pathway, in cervical carcinomas". Oncology Reports 10, no. 5 (2003): 1195-1200. https://doi.org/10.3892/or.10.5.1195
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