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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September-October 2003 Volume 10 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Induction of antigen specific cellular immunity by vaccination with peptides from MN/CA IX in renal cell carcinoma

  • Authors:
    • Kazuhiro Shimizu
    • Hirotsugu Uemura
    • Motoyoshi Yoshikawa
    • Katsunori Yoshida
    • Yoshihiko Hirao
    • Kumiko Iwashima
    • Shinsuke Saga
    • Kazuhiro Yoshikawa

  • View Affiliations / Copyright

    Affiliations: Department of Urology, Nara Medical University, Nara 634-0813, Japan
  • Pages: 1307-1311
    |
    Published online on: September 1, 2003
       https://doi.org/10.3892/or.10.5.1307
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Abstract

We investigated the induction of the specific immunity for renal cell carcinomas (RCC) using MN/CA IX, a tumor-associated antigen frequently expressed in RCC. We have generated 9-mer peptide derived from MN/CA IX and examined the antigenicity as a vaccine to induce specific immunity for RCC. To use mouse syngeneic system, we transfected human MN/CA9 cDNA into RenCa and BALB-3T3 cells originally from BALB/c mouse, and established MN/CA IX expressing mouse cell lines, i.e., MN-RenCa and MN-3T3. The immunization of BALB/c mouse with MN-RenCa cells resulted in the induction of cytotoxic T lymphocytes (CTL) against MN/CA IX expressing cells and the CTL clone was established from bulked CTL. This CTL clone specifically lyzed MN-3T3 cells, but not parental cells. To identify the targeted epitope binding to H-2Kd antigen, three 9-mer peptides (A, B, C-peptide) of human MN/CA IX compatible with the H-2Kd as well as HLA-A24 binding motif was synthesized. The cloned CTL targeted the B-peptide pulsed BALB-3T3 cells as well as MN-3T3 cells. Furthermore, spleen cells from BALB/c mouse immunized with B-peptide reacted against MN-RenCa cells. These results suggest that the peptides derived from MN/CA IX containing HLA-A24 binding motif may be useful as a potent tumor vaccine for the treatment of human RCC, and in mouse models.

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Copy and paste a formatted citation
Spandidos Publications style
Shimizu K, Uemura H, Yoshikawa M, Yoshida K, Hirao Y, Iwashima K, Saga S and Yoshikawa K: Induction of antigen specific cellular immunity by vaccination with peptides from MN/CA IX in renal cell carcinoma. Oncol Rep 10: 1307-1311, 2003.
APA
Shimizu, K., Uemura, H., Yoshikawa, M., Yoshida, K., Hirao, Y., Iwashima, K. ... Yoshikawa, K. (2003). Induction of antigen specific cellular immunity by vaccination with peptides from MN/CA IX in renal cell carcinoma. Oncology Reports, 10, 1307-1311. https://doi.org/10.3892/or.10.5.1307
MLA
Shimizu, K., Uemura, H., Yoshikawa, M., Yoshida, K., Hirao, Y., Iwashima, K., Saga, S., Yoshikawa, K."Induction of antigen specific cellular immunity by vaccination with peptides from MN/CA IX in renal cell carcinoma". Oncology Reports 10.5 (2003): 1307-1311.
Chicago
Shimizu, K., Uemura, H., Yoshikawa, M., Yoshida, K., Hirao, Y., Iwashima, K., Saga, S., Yoshikawa, K."Induction of antigen specific cellular immunity by vaccination with peptides from MN/CA IX in renal cell carcinoma". Oncology Reports 10, no. 5 (2003): 1307-1311. https://doi.org/10.3892/or.10.5.1307
Copy and paste a formatted citation
x
Spandidos Publications style
Shimizu K, Uemura H, Yoshikawa M, Yoshida K, Hirao Y, Iwashima K, Saga S and Yoshikawa K: Induction of antigen specific cellular immunity by vaccination with peptides from MN/CA IX in renal cell carcinoma. Oncol Rep 10: 1307-1311, 2003.
APA
Shimizu, K., Uemura, H., Yoshikawa, M., Yoshida, K., Hirao, Y., Iwashima, K. ... Yoshikawa, K. (2003). Induction of antigen specific cellular immunity by vaccination with peptides from MN/CA IX in renal cell carcinoma. Oncology Reports, 10, 1307-1311. https://doi.org/10.3892/or.10.5.1307
MLA
Shimizu, K., Uemura, H., Yoshikawa, M., Yoshida, K., Hirao, Y., Iwashima, K., Saga, S., Yoshikawa, K."Induction of antigen specific cellular immunity by vaccination with peptides from MN/CA IX in renal cell carcinoma". Oncology Reports 10.5 (2003): 1307-1311.
Chicago
Shimizu, K., Uemura, H., Yoshikawa, M., Yoshida, K., Hirao, Y., Iwashima, K., Saga, S., Yoshikawa, K."Induction of antigen specific cellular immunity by vaccination with peptides from MN/CA IX in renal cell carcinoma". Oncology Reports 10, no. 5 (2003): 1307-1311. https://doi.org/10.3892/or.10.5.1307
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