search button

Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms in patients with small cell and non-small cell lung cancer

  • Authors:
    • Krzysztof Siemianowicz
    • Jan Gminski
    • Wojciech Garczorz
    • Natalia Slabiak
    • Malgorzata Goss
    • Marek Machalski
    • Helena Magiera-Molendowska

  • View Affiliations

  • Published online on: September 1, 2003     https://doi.org/10.3892/or.10.5.1341
  • Pages: 1341-1344
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Two mutations of methylenetetrahydrofolate reductase (MTHFR) gene (C677T and A1298C) may lead to a decreased activity of the enzyme. These mutations may change a risk of some cancers. We evaluated these two polymorphisms of MTHFR in patients with small cell lung cancer (SCLC) and non-small cell lung cancer (NCSCL). All lung cancer patients had statistically significantly higher percentage of MTHFR 677TT genotype in comparison with non-cancer controls. There were no statistically significant differences in the distribution of MTHFR 1298 genotypes. Neither of the polymorphisms presented any statistically significant differences between SCLC and NSCLC.

Related Articles

Journal Cover

September-October 2003
Volume 10 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 4.2
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Siemianowicz K, Gminski J, Garczorz W, Slabiak N, Goss M, Machalski M and Magiera-Molendowska H: Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms in patients with small cell and non-small cell lung cancer. Oncol Rep 10: 1341-1344, 2003
APA
Siemianowicz, K., Gminski, J., Garczorz, W., Slabiak, N., Goss, M., Machalski, M., & Magiera-Molendowska, H. (2003). Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms in patients with small cell and non-small cell lung cancer. Oncology Reports, 10, 1341-1344. https://doi.org/10.3892/or.10.5.1341
MLA
Siemianowicz, K., Gminski, J., Garczorz, W., Slabiak, N., Goss, M., Machalski, M., Magiera-Molendowska, H."Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms in patients with small cell and non-small cell lung cancer". Oncology Reports 10.5 (2003): 1341-1344.
Chicago
Siemianowicz, K., Gminski, J., Garczorz, W., Slabiak, N., Goss, M., Machalski, M., Magiera-Molendowska, H."Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms in patients with small cell and non-small cell lung cancer". Oncology Reports 10, no. 5 (2003): 1341-1344. https://doi.org/10.3892/or.10.5.1341