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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September-October 2003 Volume 10 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

VHL tumor suppressor gene: its mutation and protein level in renal cell carcinoma

  • Authors:
    • Hisashi Tsutsumi
    • Chikara Miyamoto
    • Yasuhiro Furuichi
    • Miki Yoshiike
    • Shiari Nozawa
    • Teruaki Iwamoto

  • View Affiliations / Copyright

    Affiliations: Department of Urology, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan
  • Pages: 1357-1361
    |
    Published online on: September 1, 2003
       https://doi.org/10.3892/or.10.5.1357
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Abstract

In this study, we identified mutations in the von Hippel-Lindau gene (VHL) in patients with sporadic clear cell renal carcinoma and analyzed the relationship between these VHL mutations and VHL protein (pVHL) expression levels. Analysis of VHL coding region mutations by direct polymerase chain reaction in 39 patients with clear cell renal carcinoma, who had all undergone radical nephrectomy, revealed heterozygous mutations in 7 (17.9%) of the 39 patients, including 2 novel mutations. Analysis of the levels of pVHL expression in tumor tissue samples from the 7 patients with mutations by Western blot analysis demonstrated that pVHL was not expressed in 3 patients, and that 3 subjects expressed about 50%, and 1 was similar to the normal level. These results suggest that the 3 patients who did not express pVHL had both mutation and loss of heterozygosity, and that the 3 patients who expressed about 50% of the normal pVHL level had heterozygous mutations.

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Copy and paste a formatted citation
Spandidos Publications style
Tsutsumi H, Miyamoto C, Furuichi Y, Yoshiike M, Nozawa S and Iwamoto T: VHL tumor suppressor gene: its mutation and protein level in renal cell carcinoma. Oncol Rep 10: 1357-1361, 2003.
APA
Tsutsumi, H., Miyamoto, C., Furuichi, Y., Yoshiike, M., Nozawa, S., & Iwamoto, T. (2003). VHL tumor suppressor gene: its mutation and protein level in renal cell carcinoma. Oncology Reports, 10, 1357-1361. https://doi.org/10.3892/or.10.5.1357
MLA
Tsutsumi, H., Miyamoto, C., Furuichi, Y., Yoshiike, M., Nozawa, S., Iwamoto, T."VHL tumor suppressor gene: its mutation and protein level in renal cell carcinoma". Oncology Reports 10.5 (2003): 1357-1361.
Chicago
Tsutsumi, H., Miyamoto, C., Furuichi, Y., Yoshiike, M., Nozawa, S., Iwamoto, T."VHL tumor suppressor gene: its mutation and protein level in renal cell carcinoma". Oncology Reports 10, no. 5 (2003): 1357-1361. https://doi.org/10.3892/or.10.5.1357
Copy and paste a formatted citation
x
Spandidos Publications style
Tsutsumi H, Miyamoto C, Furuichi Y, Yoshiike M, Nozawa S and Iwamoto T: VHL tumor suppressor gene: its mutation and protein level in renal cell carcinoma. Oncol Rep 10: 1357-1361, 2003.
APA
Tsutsumi, H., Miyamoto, C., Furuichi, Y., Yoshiike, M., Nozawa, S., & Iwamoto, T. (2003). VHL tumor suppressor gene: its mutation and protein level in renal cell carcinoma. Oncology Reports, 10, 1357-1361. https://doi.org/10.3892/or.10.5.1357
MLA
Tsutsumi, H., Miyamoto, C., Furuichi, Y., Yoshiike, M., Nozawa, S., Iwamoto, T."VHL tumor suppressor gene: its mutation and protein level in renal cell carcinoma". Oncology Reports 10.5 (2003): 1357-1361.
Chicago
Tsutsumi, H., Miyamoto, C., Furuichi, Y., Yoshiike, M., Nozawa, S., Iwamoto, T."VHL tumor suppressor gene: its mutation and protein level in renal cell carcinoma". Oncology Reports 10, no. 5 (2003): 1357-1361. https://doi.org/10.3892/or.10.5.1357
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