Expression of a 65 kDa oncofetal protein in human prostatic carcinoma

  • Authors:
    • Margaret Hanausek
    • Zbigniew Walaszek
    • Terri M. King
    • Christopher I. Amos
  • View Affiliations

  • Published online on: September 1, 2003     https://doi.org/10.3892/or.10.5.1387
  • Pages: 1387-1392
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The concentration of a novel 65 kDa oncofetal protein, p65, was measured in the sera of patients with prostatic malignancies using an enzyme-linked immunosorbent assay. The prostate cancer sera were positive for p65 in 40 out of 59 cases (68%), while only 7 of 79 normal sera (9%) and 12 of 61 sera from patients with benign diseases (20%) were positive. The detection system had an overall sensitivity of 68% and a specificity of 86%. Elevated p65 levels correlated positively with the pathologic stages of the prostate cancer. Using this marker in concert with PSA may increase our ability to evaluate treatment response and aid in early detection of prostate cancer.

Related Articles

Journal Cover

September-October 2003
Volume 10 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Hanausek M, Walaszek Z, King TM and Amos CI: Expression of a 65 kDa oncofetal protein in human prostatic carcinoma. Oncol Rep 10: 1387-1392, 2003
APA
Hanausek, M., Walaszek, Z., King, T.M., & Amos, C.I. (2003). Expression of a 65 kDa oncofetal protein in human prostatic carcinoma. Oncology Reports, 10, 1387-1392. https://doi.org/10.3892/or.10.5.1387
MLA
Hanausek, M., Walaszek, Z., King, T. M., Amos, C. I."Expression of a 65 kDa oncofetal protein in human prostatic carcinoma". Oncology Reports 10.5 (2003): 1387-1392.
Chicago
Hanausek, M., Walaszek, Z., King, T. M., Amos, C. I."Expression of a 65 kDa oncofetal protein in human prostatic carcinoma". Oncology Reports 10, no. 5 (2003): 1387-1392. https://doi.org/10.3892/or.10.5.1387