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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September-October 2003 Volume 10 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Chromosomal imbalance in esophageal squamous cell carcinoma: 3q gain correlates with tumor progression but not prognostic significance

  • Authors:
    • Tsuyoshi Noguchi
    • Yasuhiko Kimura
    • Shinsuke Takeno
    • Masao Chujo
    • Yuzo Uchida
    • Wolfram Mueller
    • Helmut E. Gabbert

  • View Affiliations / Copyright

    Affiliations: Department of Oncological Science (Surgery II), Oita Medical University, Oita 879-5593, Japan. tnoguc@oita-med.ac.jp
  • Pages: 1393-1400
    |
    Published online on: September 1, 2003
       https://doi.org/10.3892/or.10.5.1393
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Abstract

DNA copy number changes were analyzed by comparative genomic hybridization (CGH) in 53 esophageal squamous cell carcinomas (ESCC) to clarify the relationship between DNA sequence copy number aberrations and clinicopathological factors. Changes in DNA copy number were observed in all 53 ESCC patients. The average number of DNA copy number gains was 9.32 (range 1-23), most frequently located on chromosomes 3q, 5p, 8q, 11q and Xq in over 40% of tumors. Loss of DNA copy number was detected on 3p, 5q, 4p, 1p and Xp in over 20% of tumors. No statistically significant differences in the frequency of DNA copy number changes were observed. However, some loci showed correlation with clinicopathologic factors: 8q gain correlated with the pattern of tumor infiltration, 3q gain correlated with pT, 2p gain, 1p loss and 16p loss correlated with lymphatic invasion, and 3q gain correlated with clinical stage. Thus, in ESCC, gain of 3q is the only specific recurrent pattern of DNA aberration that correlates with clinicopathologic parameters, although no particular loci correlated with patient prognosis. Further CGH analysis may reveal new, recurrent genetic changes in ESCC affecting chromosomes sites that harbor genes known to participate in tumorigenesis and progression of several human malignant neoplasms.

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Copy and paste a formatted citation
Spandidos Publications style
Noguchi T, Kimura Y, Takeno S, Chujo M, Uchida Y, Mueller W and Gabbert HE: Chromosomal imbalance in esophageal squamous cell carcinoma: 3q gain correlates with tumor progression but not prognostic significance. Oncol Rep 10: 1393-1400, 2003.
APA
Noguchi, T., Kimura, Y., Takeno, S., Chujo, M., Uchida, Y., Mueller, W., & Gabbert, H.E. (2003). Chromosomal imbalance in esophageal squamous cell carcinoma: 3q gain correlates with tumor progression but not prognostic significance. Oncology Reports, 10, 1393-1400. https://doi.org/10.3892/or.10.5.1393
MLA
Noguchi, T., Kimura, Y., Takeno, S., Chujo, M., Uchida, Y., Mueller, W., Gabbert, H. E."Chromosomal imbalance in esophageal squamous cell carcinoma: 3q gain correlates with tumor progression but not prognostic significance". Oncology Reports 10.5 (2003): 1393-1400.
Chicago
Noguchi, T., Kimura, Y., Takeno, S., Chujo, M., Uchida, Y., Mueller, W., Gabbert, H. E."Chromosomal imbalance in esophageal squamous cell carcinoma: 3q gain correlates with tumor progression but not prognostic significance". Oncology Reports 10, no. 5 (2003): 1393-1400. https://doi.org/10.3892/or.10.5.1393
Copy and paste a formatted citation
x
Spandidos Publications style
Noguchi T, Kimura Y, Takeno S, Chujo M, Uchida Y, Mueller W and Gabbert HE: Chromosomal imbalance in esophageal squamous cell carcinoma: 3q gain correlates with tumor progression but not prognostic significance. Oncol Rep 10: 1393-1400, 2003.
APA
Noguchi, T., Kimura, Y., Takeno, S., Chujo, M., Uchida, Y., Mueller, W., & Gabbert, H.E. (2003). Chromosomal imbalance in esophageal squamous cell carcinoma: 3q gain correlates with tumor progression but not prognostic significance. Oncology Reports, 10, 1393-1400. https://doi.org/10.3892/or.10.5.1393
MLA
Noguchi, T., Kimura, Y., Takeno, S., Chujo, M., Uchida, Y., Mueller, W., Gabbert, H. E."Chromosomal imbalance in esophageal squamous cell carcinoma: 3q gain correlates with tumor progression but not prognostic significance". Oncology Reports 10.5 (2003): 1393-1400.
Chicago
Noguchi, T., Kimura, Y., Takeno, S., Chujo, M., Uchida, Y., Mueller, W., Gabbert, H. E."Chromosomal imbalance in esophageal squamous cell carcinoma: 3q gain correlates with tumor progression but not prognostic significance". Oncology Reports 10, no. 5 (2003): 1393-1400. https://doi.org/10.3892/or.10.5.1393
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