Topical vidarabine or 5-fluorouracil treatment against persistent HPV in genital (pre)cancerous lesions

  • Authors:
    • Kenji Niwa
    • Keiko Tagami
    • Zenglin Lian
    • Jingchun Gao
    • Hideki Mori
    • Teruhiko Tamaya
  • View Affiliations

  • Published online on: September 1, 2003     https://doi.org/10.3892/or.10.5.1437
  • Pages: 1437-1441
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Abstract

In the present study, effectiveness of topical vidarabine or subsequent 5-fluorouracil (5-FU) administration was examined against persistent genital human papillomavirus (HPV) infection after local surgery. Thirty patients underwent local eradication treatment of uterine cervical intra-epithelial neoplasia (CIN) and stage Ia1 uterine cervical cancers. HPV typing was performed by PCR-RFLP analysis. HPV infection was detected pre-operatively in 29 of 30 patients. Of these, HPV was still present in the 20 patients within two months after the therapy. Topical administration of vidarabine or subsequent 5-FU once a week for four weeks was performed to the post-operative persistent HPV-positive cases. HPV infection was abolished in 1 of 10 (10%) with topical vidarabine, and in 2 of 4 vidarabine-resistant cases (50%) with topical 5-FU. Topical vidarabine or 5-FU treatment is beneficial for HPV-positive cases after local surgical excision.

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September-October 2003
Volume 10 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Niwa K, Tagami K, Lian Z, Gao J, Mori H and Tamaya T: Topical vidarabine or 5-fluorouracil treatment against persistent HPV in genital (pre)cancerous lesions. Oncol Rep 10: 1437-1441, 2003
APA
Niwa, K., Tagami, K., Lian, Z., Gao, J., Mori, H., & Tamaya, T. (2003). Topical vidarabine or 5-fluorouracil treatment against persistent HPV in genital (pre)cancerous lesions. Oncology Reports, 10, 1437-1441. https://doi.org/10.3892/or.10.5.1437
MLA
Niwa, K., Tagami, K., Lian, Z., Gao, J., Mori, H., Tamaya, T."Topical vidarabine or 5-fluorouracil treatment against persistent HPV in genital (pre)cancerous lesions". Oncology Reports 10.5 (2003): 1437-1441.
Chicago
Niwa, K., Tagami, K., Lian, Z., Gao, J., Mori, H., Tamaya, T."Topical vidarabine or 5-fluorouracil treatment against persistent HPV in genital (pre)cancerous lesions". Oncology Reports 10, no. 5 (2003): 1437-1441. https://doi.org/10.3892/or.10.5.1437