The increase of CD57+ T cells in the peripheral blood and their impaired immune functions in patients with advanced gastric cancer

  • Authors:
    • Kentaro Chochi
    • Takashi Ichikura
    • Takashi Majima
    • Toshinobu Kawabata
    • Atsushi Matsumoto
    • Hidekazu Sugasawa
    • Nobuaki Kawarabayashi
    • Eiji Takayama
    • Hoshio Hiraide
    • Shuhji Seki
    • Hidetaka Mochizuki
  • View Affiliations

  • Published online on: September 1, 2003     https://doi.org/10.3892/or.10.5.1443
  • Pages: 1443-1448
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

In addition to natural killer (NK) cells, T cells expressing natural killer cell markers, CD56 or CD57 (NK type T cells), have been considered to play an important role in antitumor immunity. We examined the proportion of NK cell and NK type T cell subsets in the peripheral blood from patients with gastric cancer. The IFN-γ production capacity and population of cytoplasmic perforin positive cells in peripheral blood mononuclear cells (PBMC) were evaluated. Peripheral blood samples were obtained from 56 patients with gastric cancer and 21 healthy volunteers. The proportion of CD56− CD57+ T cells (CD57+ T cells) was significantly higher in advanced gastric cancer patients than those in healthy volunteers and patients with early stage gastric cancer, whereas no correlation was observed between the proportion of CD56+ T cells or NK cells and tumor progression. Furthermore, a significant decrease of CD8+ CD57+ T cells was found in patients with advanced gastric cancer. The proportion of CD57+ T cells did not correlate with interferon-γ (IFN-γ) production from PBMC in gastric cancer patients, although a significant correlation was found between them in healthy volunteers. The proportion of perforin positive CD57+ T cells, especially CD8+ CD57+ T cells, in patients with gastric cancer was markedly lower than that in healthy volunteers. Collectively, although the proportion of CD57+ T cells in PBMC was found to increase with tumor progression, their function in antitumor immunity is impaired in patients with gastric cancer.

Related Articles

Journal Cover

September-October 2003
Volume 10 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Chochi K, Ichikura T, Majima T, Kawabata T, Matsumoto A, Sugasawa H, Kawarabayashi N, Takayama E, Hiraide H, Seki S, Seki S, et al: The increase of CD57+ T cells in the peripheral blood and their impaired immune functions in patients with advanced gastric cancer. Oncol Rep 10: 1443-1448, 2003.
APA
Chochi, K., Ichikura, T., Majima, T., Kawabata, T., Matsumoto, A., Sugasawa, H. ... Mochizuki, H. (2003). The increase of CD57+ T cells in the peripheral blood and their impaired immune functions in patients with advanced gastric cancer. Oncology Reports, 10, 1443-1448. https://doi.org/10.3892/or.10.5.1443
MLA
Chochi, K., Ichikura, T., Majima, T., Kawabata, T., Matsumoto, A., Sugasawa, H., Kawarabayashi, N., Takayama, E., Hiraide, H., Seki, S., Mochizuki, H."The increase of CD57+ T cells in the peripheral blood and their impaired immune functions in patients with advanced gastric cancer". Oncology Reports 10.5 (2003): 1443-1448.
Chicago
Chochi, K., Ichikura, T., Majima, T., Kawabata, T., Matsumoto, A., Sugasawa, H., Kawarabayashi, N., Takayama, E., Hiraide, H., Seki, S., Mochizuki, H."The increase of CD57+ T cells in the peripheral blood and their impaired immune functions in patients with advanced gastric cancer". Oncology Reports 10, no. 5 (2003): 1443-1448. https://doi.org/10.3892/or.10.5.1443