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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September-October 2003 Volume 10 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Pentostatin in T-non-Hodgkin's lymphomas: Efficacy and effect on CD26+ T lymphocytes

  • Authors:
    • Nam H. Dang
    • Fredrick B. Hagemeister
    • Madeleine Duvic
    • Jorge E. Romaguera
    • Anas Younes
    • Dan Jones
    • Barry Samuels
    • Luis E. Fayad
    • Barbara Pro
    • Felipe Samaniego
    • Andreas Sarris
    • Andre Goy
    • Peter McLaughlin
    • Ann T. Tong
    • Pamela L. Walker
    • Lili Paz Tiongson
    • Terry L. Smith
    • Yang O. Huh
    • Chikao Morimoto
    • Maria A. Rodriguez

  • View Affiliations / Copyright

    Affiliations: MD Anderson Cancer Center, Houston, TX 77030, USA. nhdang@mail.mdanderson.org
  • Pages: 1513-1518
    |
    Published online on: September 1, 2003
       https://doi.org/10.3892/or.10.5.1513
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Abstract

Pentostatin is an adenosine deaminase (ADA) inhibitor with antineoplastic activity. CD26 is a surface glycoprotein with a key role in T cell function as the ADA binding protein. We conducted a phase II study to evaluate pentostatin efficacy in relapsed T-non-Hodgkin's lymphoma (T-NHL) and to correlate response with tumor CD26 expression. We also examined the lymphopenic effect of pentostatin on CD26+ T lymphocytes. Eighteen patients were registered for the study. Pentostatin was administered as intravenous bolus daily over 3 days at an initial dose of 5 mg/m2/day, repeated every 4 weeks. CD26 surface expression on tumor cells and T lymphocytes was determined by flow cytometry. Out of 14 patients evaluable for response, there was 1 (7%) complete response (CR) and 6 (43%) partial responses (PR). Median progression-free survival for responders was 6 months (range: 2-15 months); median number of courses was 4 (range: 1-6). Responders included 1 of 2 CD26+ and 5 of 9 CD26− cases. Pentostatin also specifically depleted CD26+ rather than CD26− T lymphocytes, potentially associated with immunosuppression. We therefore conclude that while pentostatin is a safe and active agent for T-NHL regardless of CD26 expression, it may selectively deplete CD26+ T lymphocytes, with potentially significant clinical implications.

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Copy and paste a formatted citation
Spandidos Publications style
Dang NH, Hagemeister FB, Duvic M, Romaguera JE, Younes A, Jones D, Samuels B, Fayad LE, Pro B, Samaniego F, Samaniego F, et al: Pentostatin in T-non-Hodgkin's lymphomas: Efficacy and effect on CD26+ T lymphocytes. Oncol Rep 10: 1513-1518, 2003.
APA
Dang, N.H., Hagemeister, F.B., Duvic, M., Romaguera, J.E., Younes, A., Jones, D. ... Rodriguez, M.A. (2003). Pentostatin in T-non-Hodgkin's lymphomas: Efficacy and effect on CD26+ T lymphocytes. Oncology Reports, 10, 1513-1518. https://doi.org/10.3892/or.10.5.1513
MLA
Dang, N. H., Hagemeister, F. B., Duvic, M., Romaguera, J. E., Younes, A., Jones, D., Samuels, B., Fayad, L. E., Pro, B., Samaniego, F., Sarris, A., Goy, A., McLaughlin, P., Tong, A. T., Walker, P. L., Tiongson, L. P., Smith, T. L., Huh, Y. O., Morimoto, C., Rodriguez, M. A."Pentostatin in T-non-Hodgkin's lymphomas: Efficacy and effect on CD26+ T lymphocytes". Oncology Reports 10.5 (2003): 1513-1518.
Chicago
Dang, N. H., Hagemeister, F. B., Duvic, M., Romaguera, J. E., Younes, A., Jones, D., Samuels, B., Fayad, L. E., Pro, B., Samaniego, F., Sarris, A., Goy, A., McLaughlin, P., Tong, A. T., Walker, P. L., Tiongson, L. P., Smith, T. L., Huh, Y. O., Morimoto, C., Rodriguez, M. A."Pentostatin in T-non-Hodgkin's lymphomas: Efficacy and effect on CD26+ T lymphocytes". Oncology Reports 10, no. 5 (2003): 1513-1518. https://doi.org/10.3892/or.10.5.1513
Copy and paste a formatted citation
x
Spandidos Publications style
Dang NH, Hagemeister FB, Duvic M, Romaguera JE, Younes A, Jones D, Samuels B, Fayad LE, Pro B, Samaniego F, Samaniego F, et al: Pentostatin in T-non-Hodgkin's lymphomas: Efficacy and effect on CD26+ T lymphocytes. Oncol Rep 10: 1513-1518, 2003.
APA
Dang, N.H., Hagemeister, F.B., Duvic, M., Romaguera, J.E., Younes, A., Jones, D. ... Rodriguez, M.A. (2003). Pentostatin in T-non-Hodgkin's lymphomas: Efficacy and effect on CD26+ T lymphocytes. Oncology Reports, 10, 1513-1518. https://doi.org/10.3892/or.10.5.1513
MLA
Dang, N. H., Hagemeister, F. B., Duvic, M., Romaguera, J. E., Younes, A., Jones, D., Samuels, B., Fayad, L. E., Pro, B., Samaniego, F., Sarris, A., Goy, A., McLaughlin, P., Tong, A. T., Walker, P. L., Tiongson, L. P., Smith, T. L., Huh, Y. O., Morimoto, C., Rodriguez, M. A."Pentostatin in T-non-Hodgkin's lymphomas: Efficacy and effect on CD26+ T lymphocytes". Oncology Reports 10.5 (2003): 1513-1518.
Chicago
Dang, N. H., Hagemeister, F. B., Duvic, M., Romaguera, J. E., Younes, A., Jones, D., Samuels, B., Fayad, L. E., Pro, B., Samaniego, F., Sarris, A., Goy, A., McLaughlin, P., Tong, A. T., Walker, P. L., Tiongson, L. P., Smith, T. L., Huh, Y. O., Morimoto, C., Rodriguez, M. A."Pentostatin in T-non-Hodgkin's lymphomas: Efficacy and effect on CD26+ T lymphocytes". Oncology Reports 10, no. 5 (2003): 1513-1518. https://doi.org/10.3892/or.10.5.1513
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