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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September-October 2003 Volume 10 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Induction chemotherapy for bone sarcoma in adults: Correlation of results with erbB-4 expression

  • Authors:
    • Ofer Merimsky
    • Yehuda Kollender
    • Josephine Issakov
    • Moshe Inbar
    • Gideon Flusser
    • Dafna Benayahu
    • Isaac Meller
    • Jacob Bickels

  • View Affiliations / Copyright

    Affiliations: Unit of Soft Tissue and Bone Oncology, Division of Oncology, The Tel-Aviv Sourasky Medical Center, Tel-Aviv 64239, Israel. merimsky@zahav.net.il
  • Pages: 1593-1599
    |
    Published online on: September 1, 2003
       https://doi.org/10.3892/or.10.5.1593
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Abstract

Tumor response to preoperative chemotherapy is an important prognostic factor for localized, operable extremity osteosarcoma. Other clinical variables include tumor size and location, age and sex, and serum enzymes. Advances in molecular oncology yielded a second group of factors such as multidrug resistance status, loss of heterozygosity of RB gene, and HER2/erbB-2 expression. The aim of this study was to investigate the expression and the prognostic value of the newly described erbB-4 receptor in specimens from adults with bone sarcomas treated by pre- and postoperative chemotherapy. Thirty-three patients with non-metastatic bone sarcoma have been treated by two doxorubicin-based induction chemotherapy regimen, followed by limb sparing surgery and tailored adjuvant chemotherapy. Pre-chemotherapy tissue specimens were investigated for the expression of erbB-4 receptor and post-induction specimens were assessed for pathological response. The clinical response rates were 32-36%. The degree of induced necrosis was correlated with the disease-free survival (DFS). Patients achieving ≥90% necrosis had an improved DFS over patients with poor histological response. ErbB-4 expression was significantly associated with poor histologic response and shorter DFS. ErbB-4 expression may be used for prognostication of adults with bone sarcomas.

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Copy and paste a formatted citation
Spandidos Publications style
Merimsky O, Kollender Y, Issakov J, Inbar M, Flusser G, Benayahu D, Meller I and Bickels J: Induction chemotherapy for bone sarcoma in adults: Correlation of results with erbB-4 expression. Oncol Rep 10: 1593-1599, 2003.
APA
Merimsky, O., Kollender, Y., Issakov, J., Inbar, M., Flusser, G., Benayahu, D. ... Bickels, J. (2003). Induction chemotherapy for bone sarcoma in adults: Correlation of results with erbB-4 expression. Oncology Reports, 10, 1593-1599. https://doi.org/10.3892/or.10.5.1593
MLA
Merimsky, O., Kollender, Y., Issakov, J., Inbar, M., Flusser, G., Benayahu, D., Meller, I., Bickels, J."Induction chemotherapy for bone sarcoma in adults: Correlation of results with erbB-4 expression". Oncology Reports 10.5 (2003): 1593-1599.
Chicago
Merimsky, O., Kollender, Y., Issakov, J., Inbar, M., Flusser, G., Benayahu, D., Meller, I., Bickels, J."Induction chemotherapy for bone sarcoma in adults: Correlation of results with erbB-4 expression". Oncology Reports 10, no. 5 (2003): 1593-1599. https://doi.org/10.3892/or.10.5.1593
Copy and paste a formatted citation
x
Spandidos Publications style
Merimsky O, Kollender Y, Issakov J, Inbar M, Flusser G, Benayahu D, Meller I and Bickels J: Induction chemotherapy for bone sarcoma in adults: Correlation of results with erbB-4 expression. Oncol Rep 10: 1593-1599, 2003.
APA
Merimsky, O., Kollender, Y., Issakov, J., Inbar, M., Flusser, G., Benayahu, D. ... Bickels, J. (2003). Induction chemotherapy for bone sarcoma in adults: Correlation of results with erbB-4 expression. Oncology Reports, 10, 1593-1599. https://doi.org/10.3892/or.10.5.1593
MLA
Merimsky, O., Kollender, Y., Issakov, J., Inbar, M., Flusser, G., Benayahu, D., Meller, I., Bickels, J."Induction chemotherapy for bone sarcoma in adults: Correlation of results with erbB-4 expression". Oncology Reports 10.5 (2003): 1593-1599.
Chicago
Merimsky, O., Kollender, Y., Issakov, J., Inbar, M., Flusser, G., Benayahu, D., Meller, I., Bickels, J."Induction chemotherapy for bone sarcoma in adults: Correlation of results with erbB-4 expression". Oncology Reports 10, no. 5 (2003): 1593-1599. https://doi.org/10.3892/or.10.5.1593
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