Mutational analysis of the ST7 gene in human myeloid tumor cell lines

  • Authors:
    • Karnan Sivasundaram
    • Hiroko Suzuki
    • Masao Seto
    • Yoshitaka Hosokawa
  • View Affiliations

  • Published online on: November 1, 2003     https://doi.org/10.3892/or.10.6.1737
  • Pages: 1737-1739
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Abstract

The recently described ST7 (for suppression of tumorigenicity 7) gene has been suggested to be a major target gene on chromosome 7q31 for inactivation in a variety of human neoplasias. Loss of heterozygosity (LOH) in chromosome 7q31 is frequently observed in a variety of human neoplasias including malignant myeloid tumors. We, therefore, sought to examine a total of 22 human malignant myeloid tumor cell lines comprising 17 of acute myelogenous leukemia (AML) cell lines and 5 chronic myelogenous leukemia (CML) cell lines for somatic mutations of the ST7 gene by means of bidirectional direct DNA sequencing analysis. As a result, no mutations were detected in any of these cell lines examined. In addition, our analysis of two breast tumor cell lines, which had been reported to harbour ST7 mutations, provided no evidence for such mutations. Thus, our results strongly suggest that somatic mutations of ST7 do not commonly contribute to the molecular pathogenesis of human malignant myeloid tumors and further raise questions regarding the pathological role of ST7 as a tumor suppressor gene (TSG) in a variety of human neoplasias.

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November-December 2003
Volume 10 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Sivasundaram K, Suzuki H, Seto M and Hosokawa Y: Mutational analysis of the ST7 gene in human myeloid tumor cell lines. Oncol Rep 10: 1737-1739, 2003
APA
Sivasundaram, K., Suzuki, H., Seto, M., & Hosokawa, Y. (2003). Mutational analysis of the ST7 gene in human myeloid tumor cell lines. Oncology Reports, 10, 1737-1739. https://doi.org/10.3892/or.10.6.1737
MLA
Sivasundaram, K., Suzuki, H., Seto, M., Hosokawa, Y."Mutational analysis of the ST7 gene in human myeloid tumor cell lines". Oncology Reports 10.6 (2003): 1737-1739.
Chicago
Sivasundaram, K., Suzuki, H., Seto, M., Hosokawa, Y."Mutational analysis of the ST7 gene in human myeloid tumor cell lines". Oncology Reports 10, no. 6 (2003): 1737-1739. https://doi.org/10.3892/or.10.6.1737