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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November-December 2003 Volume 10 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Mutational analysis of the ST7 gene in human myeloid tumor cell lines

  • Authors:
    • Karnan Sivasundaram
    • Hiroko Suzuki
    • Masao Seto
    • Yoshitaka Hosokawa

  • View Affiliations / Copyright

    Affiliations: Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan
  • Pages: 1737-1739
    |
    Published online on: November 1, 2003
       https://doi.org/10.3892/or.10.6.1737
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Abstract

The recently described ST7 (for suppression of tumorigenicity 7) gene has been suggested to be a major target gene on chromosome 7q31 for inactivation in a variety of human neoplasias. Loss of heterozygosity (LOH) in chromosome 7q31 is frequently observed in a variety of human neoplasias including malignant myeloid tumors. We, therefore, sought to examine a total of 22 human malignant myeloid tumor cell lines comprising 17 of acute myelogenous leukemia (AML) cell lines and 5 chronic myelogenous leukemia (CML) cell lines for somatic mutations of the ST7 gene by means of bidirectional direct DNA sequencing analysis. As a result, no mutations were detected in any of these cell lines examined. In addition, our analysis of two breast tumor cell lines, which had been reported to harbour ST7 mutations, provided no evidence for such mutations. Thus, our results strongly suggest that somatic mutations of ST7 do not commonly contribute to the molecular pathogenesis of human malignant myeloid tumors and further raise questions regarding the pathological role of ST7 as a tumor suppressor gene (TSG) in a variety of human neoplasias.

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Copy and paste a formatted citation
Spandidos Publications style
Sivasundaram K, Suzuki H, Seto M and Hosokawa Y: Mutational analysis of the ST7 gene in human myeloid tumor cell lines. Oncol Rep 10: 1737-1739, 2003.
APA
Sivasundaram, K., Suzuki, H., Seto, M., & Hosokawa, Y. (2003). Mutational analysis of the ST7 gene in human myeloid tumor cell lines. Oncology Reports, 10, 1737-1739. https://doi.org/10.3892/or.10.6.1737
MLA
Sivasundaram, K., Suzuki, H., Seto, M., Hosokawa, Y."Mutational analysis of the ST7 gene in human myeloid tumor cell lines". Oncology Reports 10.6 (2003): 1737-1739.
Chicago
Sivasundaram, K., Suzuki, H., Seto, M., Hosokawa, Y."Mutational analysis of the ST7 gene in human myeloid tumor cell lines". Oncology Reports 10, no. 6 (2003): 1737-1739. https://doi.org/10.3892/or.10.6.1737
Copy and paste a formatted citation
x
Spandidos Publications style
Sivasundaram K, Suzuki H, Seto M and Hosokawa Y: Mutational analysis of the ST7 gene in human myeloid tumor cell lines. Oncol Rep 10: 1737-1739, 2003.
APA
Sivasundaram, K., Suzuki, H., Seto, M., & Hosokawa, Y. (2003). Mutational analysis of the ST7 gene in human myeloid tumor cell lines. Oncology Reports, 10, 1737-1739. https://doi.org/10.3892/or.10.6.1737
MLA
Sivasundaram, K., Suzuki, H., Seto, M., Hosokawa, Y."Mutational analysis of the ST7 gene in human myeloid tumor cell lines". Oncology Reports 10.6 (2003): 1737-1739.
Chicago
Sivasundaram, K., Suzuki, H., Seto, M., Hosokawa, Y."Mutational analysis of the ST7 gene in human myeloid tumor cell lines". Oncology Reports 10, no. 6 (2003): 1737-1739. https://doi.org/10.3892/or.10.6.1737
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