Repeated hepatic arterial infusion chemotherapy using an implanted port system in patients with unresectable malignant liver neoplasms: Significant factors affecting early hepatic arterial occlusion

  • Authors:
    • Ayumi Hamada
    • Koichiro Yamakado
    • Atsuhiro Nakatsuka
    • Naoshi Tanaka
    • Kan Takeda
  • View Affiliations

  • Published online on: November 1, 2003     https://doi.org/10.3892/or.10.6.1821
  • Pages: 1821-1827
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Abstract

The purpose of this study was to identify significant factors affecting early hepatic arterial occlusion in patients who received repeated hepatic arterial infusion chemotherapy using an implanted port system. Eighty-five patients with unresectable liver neoplasms who underwent implantation of the port system were studied. Arterial infusion chemotherapy was performed every 1-4 weeks. Arterial occlusion was evaluated by hepatic arteriography performed via the port every 3 months. Twenty variables were analyzed using univariate and multivariate analyses to identify significant factors affecting early hepatic arterial occlusion. Hepatic arterial occlusion was found in 25.9% (22/85) of the patients. Thirteen of them experienced early arterial occlusion within 6 months. The mean survival period was significantly worse in patients who experienced early arterial occlusion than those who did not (16 months vs. 26 months, p<0.05). In the multivariate analysis, the following 3 variables had independent value for early arterial occlusion; i) diameter of the common hepatic artery, ii) gender, and iii) previous systemic chemotherapy. Early arterial occlusion affects therapeutic effects and survival in patients who undergo arterial infusion chemotherapy with an implanted port. Factors demonstrated here are important to classify patients at risk of early hepatic arterial occlusion.

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November-December 2003
Volume 10 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Hamada A, Yamakado K, Nakatsuka A, Tanaka N and Takeda K: Repeated hepatic arterial infusion chemotherapy using an implanted port system in patients with unresectable malignant liver neoplasms: Significant factors affecting early hepatic arterial occlusion. Oncol Rep 10: 1821-1827, 2003.
APA
Hamada, A., Yamakado, K., Nakatsuka, A., Tanaka, N., & Takeda, K. (2003). Repeated hepatic arterial infusion chemotherapy using an implanted port system in patients with unresectable malignant liver neoplasms: Significant factors affecting early hepatic arterial occlusion. Oncology Reports, 10, 1821-1827. https://doi.org/10.3892/or.10.6.1821
MLA
Hamada, A., Yamakado, K., Nakatsuka, A., Tanaka, N., Takeda, K."Repeated hepatic arterial infusion chemotherapy using an implanted port system in patients with unresectable malignant liver neoplasms: Significant factors affecting early hepatic arterial occlusion". Oncology Reports 10.6 (2003): 1821-1827.
Chicago
Hamada, A., Yamakado, K., Nakatsuka, A., Tanaka, N., Takeda, K."Repeated hepatic arterial infusion chemotherapy using an implanted port system in patients with unresectable malignant liver neoplasms: Significant factors affecting early hepatic arterial occlusion". Oncology Reports 10, no. 6 (2003): 1821-1827. https://doi.org/10.3892/or.10.6.1821