Plasma leptin and colorectal cancer risk: A prospective study in Northern Sweden

  • Authors:
    • Pär Stattin
    • Richard Palmqvist
    • Stefan Söderberg
    • Carine Biessy
    • Bjarne Ardnor
    • Göran Hallmans
    • Rudolf Kaaks
    • Tommy Olsson
  • View Affiliations

  • Published online on: November 1, 2003     https://doi.org/10.3892/or.10.6.2015
  • Pages: 2015-2021
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Abstract

Obesity is associated with an increased risk of colorectal cancer. Circulating levels of leptin are high in obesity and strongly correlated to levels of insulin. Leptin stimulates growth of colon cancer cells. In a nested case-control study, we measured leptin levels in prediagnostic plasma from 75 men and 93 women who were diagnosed with colorectal cancer mean time 3.4 years (SD 2.4) after recruitment and among 327 control subjects. Logistic regression analyses showed increases in colorectal cancer risk in men with increasing levels of leptin, odds ratios (OR) were 1.00 (ref), 0.85 (95% C.I.=0.33-2.23), 1.04 (0.43-2.53), and 2.15 (0.89-5.22), (pfor trend=0.08). There was a distinct threshold between the third and fourth quartile of leptin, and the odds ratio for top quartile vs. three bottom quartiles was 2.28 (1.09-4.76). Adjustment for body mass index and insulin did not affect risk estimates. In separate analysis, odds ratio for top vs. bottom tertile of colon cancer was 1.96 (95% C.I.=0.72-5.29), whereas no increase was seen for rectal cancer. In women, no association between leptin and risk was seen. These data support the hypothesis that leptin is a risk marker for colorectal cancer in men, but not in women.

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November-December 2003
Volume 10 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Stattin P, Palmqvist R, Söderberg S, Biessy C, Ardnor B, Hallmans G, Kaaks R and Olsson T: Plasma leptin and colorectal cancer risk: A prospective study in Northern Sweden. Oncol Rep 10: 2015-2021, 2003
APA
Stattin, P., Palmqvist, R., Söderberg, S., Biessy, C., Ardnor, B., Hallmans, G. ... Olsson, T. (2003). Plasma leptin and colorectal cancer risk: A prospective study in Northern Sweden. Oncology Reports, 10, 2015-2021. https://doi.org/10.3892/or.10.6.2015
MLA
Stattin, P., Palmqvist, R., Söderberg, S., Biessy, C., Ardnor, B., Hallmans, G., Kaaks, R., Olsson, T."Plasma leptin and colorectal cancer risk: A prospective study in Northern Sweden". Oncology Reports 10.6 (2003): 2015-2021.
Chicago
Stattin, P., Palmqvist, R., Söderberg, S., Biessy, C., Ardnor, B., Hallmans, G., Kaaks, R., Olsson, T."Plasma leptin and colorectal cancer risk: A prospective study in Northern Sweden". Oncology Reports 10, no. 6 (2003): 2015-2021. https://doi.org/10.3892/or.10.6.2015