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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2004 Volume 11 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2004 Volume 11 Issue 1

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Article

Efficacy of boron neutron capture therapy on liver metastases of colon adenocarcinoma: Optical and ultrastructural study in the rat

  • Authors:
    • Rosanna Nano
    • Sergio Barni
    • Patrizia Chiari
    • Tazio Pinelli
    • Francesca Fossati
    • Saverio Altieri
    • Cecilia Zonta
    • Ubaldo Prati
    • Laura Roveda
    • Aris Zonta

  • View Affiliations / Copyright

    Affiliations: Department of Animal Biology, University of Pavia and Center of Study for Histochemistry, C.N.R., 27100 Pavia, Italy. nano@unipv.it
  • Pages: 149-153
    |
    Published online on: January 1, 2004
       https://doi.org/10.3892/or.11.1.149
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Abstract

The effect of neutron boron capture therapy (BNCT) was studied in rat tumor liver cells after induction of the liver metastases by splenic inoculation of cells from DHA/K12/TRb line. Ten days following the treatment, the BPA was injected into rats and therefore the animals were sacrificed, the liver was exposed to neutron irradiation and processed. In some experiments the liver was reimplanted (after irradiation) in syngenic animals and studied 3 days later, following sacrifice. Samples of tissue obtained from metastasised and non-metastasised areas of the liver parenchyma, before and after the neutron irradiation, were examined in light microscopy and electron microscopy. The analysis pointed out damages induced by the neutron treatment in single tumor cells mostly localised in the synusoidal blood stream. Debris and apoptotic cells were sometimes observed in the neoplastic nodules before treatment, while the tumor cell death (apoptosis) increased in the tumor cells following BNCT treatment. An intense scavenger activity of Kupffer cells after irradiation was accompanied by a strong acid phosphatase reaction detectable in wide cytoplasmic areas. In the liver parenchyma of reimplanted animals, the presence of large collagen bundles spread among the hepatocytes was observed at electron microscopy.

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Copy and paste a formatted citation
Spandidos Publications style
Nano R, Barni S, Chiari P, Pinelli T, Fossati F, Altieri S, Zonta C, Prati U, Roveda L, Zonta A, Zonta A, et al: Efficacy of boron neutron capture therapy on liver metastases of colon adenocarcinoma: Optical and ultrastructural study in the rat. Oncol Rep 11: 149-153, 2004.
APA
Nano, R., Barni, S., Chiari, P., Pinelli, T., Fossati, F., Altieri, S. ... Zonta, A. (2004). Efficacy of boron neutron capture therapy on liver metastases of colon adenocarcinoma: Optical and ultrastructural study in the rat. Oncology Reports, 11, 149-153. https://doi.org/10.3892/or.11.1.149
MLA
Nano, R., Barni, S., Chiari, P., Pinelli, T., Fossati, F., Altieri, S., Zonta, C., Prati, U., Roveda, L., Zonta, A."Efficacy of boron neutron capture therapy on liver metastases of colon adenocarcinoma: Optical and ultrastructural study in the rat". Oncology Reports 11.1 (2004): 149-153.
Chicago
Nano, R., Barni, S., Chiari, P., Pinelli, T., Fossati, F., Altieri, S., Zonta, C., Prati, U., Roveda, L., Zonta, A."Efficacy of boron neutron capture therapy on liver metastases of colon adenocarcinoma: Optical and ultrastructural study in the rat". Oncology Reports 11, no. 1 (2004): 149-153. https://doi.org/10.3892/or.11.1.149
Copy and paste a formatted citation
x
Spandidos Publications style
Nano R, Barni S, Chiari P, Pinelli T, Fossati F, Altieri S, Zonta C, Prati U, Roveda L, Zonta A, Zonta A, et al: Efficacy of boron neutron capture therapy on liver metastases of colon adenocarcinoma: Optical and ultrastructural study in the rat. Oncol Rep 11: 149-153, 2004.
APA
Nano, R., Barni, S., Chiari, P., Pinelli, T., Fossati, F., Altieri, S. ... Zonta, A. (2004). Efficacy of boron neutron capture therapy on liver metastases of colon adenocarcinoma: Optical and ultrastructural study in the rat. Oncology Reports, 11, 149-153. https://doi.org/10.3892/or.11.1.149
MLA
Nano, R., Barni, S., Chiari, P., Pinelli, T., Fossati, F., Altieri, S., Zonta, C., Prati, U., Roveda, L., Zonta, A."Efficacy of boron neutron capture therapy on liver metastases of colon adenocarcinoma: Optical and ultrastructural study in the rat". Oncology Reports 11.1 (2004): 149-153.
Chicago
Nano, R., Barni, S., Chiari, P., Pinelli, T., Fossati, F., Altieri, S., Zonta, C., Prati, U., Roveda, L., Zonta, A."Efficacy of boron neutron capture therapy on liver metastases of colon adenocarcinoma: Optical and ultrastructural study in the rat". Oncology Reports 11, no. 1 (2004): 149-153. https://doi.org/10.3892/or.11.1.149
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