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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
January 2004 Volume 11 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article

Alteration of the AT motif binding factor-1 expression in α-fetoprotein producing gastric cancer: Is it an event for differentiation and proliferation of the tumors?

Masao Iida, Johji Imura, Teruhito Furuichi, Toshio Sawada, Hirokazu Nagawa, Takahiro Fujimori
Pages: 3-7
Published online on: 01 January 2004

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Article

Expression of thymidylate synthase, thymidine phosphorylase, dihydropyrimidine dehydrogenase, E2F-1, Bak, Bcl-X, and Bcl-2, and clinical outcomes for gastric cancer patients treated with bolus 5-fluorouracil

Makoto Tahara, Atsuhi Ochiai, Junya Fujimoto, Narikazu Boku, Wataru Yasui, Atsushi Ohtsu, Eiichi Tahara, Shigeaki Yoshida
Pages: 9-15
Published online on: 01 January 2004

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Article

Intratumoral genomic heterogeneity in primary head and neck cancer and corresponding metastases detected by dual-FISH

Karl Götte, Carsten Schäfer, Frank Riedel, Norbert Arens, Karl Hörmann
Pages: 17-23
Published online on: 01 January 2004

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Article

Akt2 expression correlates with prognosis of human hepatocellular carcinoma

Xundi Xu, Masato Sakon, Hiroaki Nagano, Nobuaki Hiraoka, Hirofumi Yamamoto, Nobuyasu Hayashi, Keizo Dono, Shoji Nakamori, Koji Umeshita, Yasuhiro Ito, Nariaki Matsuura, Morito Monden
Pages: 25-32
Published online on: 01 January 2004

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Article

Basic and clinical studies on quantitative analysis of lymph node micrometastasis in oral cancer

Akiko Onishi, Koh-Ichi Nakashiro, Mariko Mihara, Tomoki Sumida, Hitoshi Kawamata, Satoru Shintani, Tadateru Aida, Tetsuhiko Tachikawa, Hiroyuki Hamakawa
Pages: 33-39
Published online on: 01 January 2004

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Article

CD44 variant 6 expression predicts response to treatment in advanced colorectal cancer

R. Bendardaf, H. Lamlum, R. Ristamäki, S. Pyrhönen
Pages: 41-45
Published online on: 01 January 2004

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Article

Identification of lymphatic vessels in malignant, adenomatous and normal colonic mucosa using the novel immunostain D2-40

F. Fogt, R. L. Zimmerman, H. M. Ross, T. Daly, R. E. Gausas
Pages: 47-50
Published online on: 01 January 2004

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Article

Expression of human telomerase reverse transcriptase mRNA in esophageal cancers and precancerous lesions

Toru Amioka, Yasuhiko Kitadai, Toru Hiyama, Shinji Tanaka, Masaharu Yoshihara, Ken Haruma, Kazuaki Chayama
Pages: 51-55
Published online on: 01 January 2004

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Article

p53 expression and p21 expression are mutually exclusive in esophageal squamous cell carcinoma

Madoka Hamada, Yoshio Naomoto, Yasuhiro Shirakawa, Tomoki Yamatsuji, Kazuhiro Noma, Takayuki Motoki, Tetsuji Nobuhisa, Takaomi Okawa, Minoru Haisa, Mehmet Gunduz, Junji Matsuoka, Noriaki Tanaka
Pages: 57-63
Published online on: 01 January 2004

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Article

DPD activity and immunohistochemical DPD expression in human breast cancer

Jun Horiguchi, Takashi Yoshida, Yukio Koibuchi, Kotaro Iijima, Jun Ninomiya, Hiroyuki Takei, Takao Yokoe, Yuichi Iino, Yasuo Morishita
Pages: 65-72
Published online on: 01 January 2004

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Article

Gemcitabine suppresses malignant ascites of human pancreatic cancer: correlation with VEGF expression in ascites

Kenichi Kuwahara, Tamito Sasaki, Kensou Kobayashi, Bunjirou Noma, Masahiro Serikawa, Tomohiro Iiboshi, Hideki Miyata, Yukio Kuwada, Masateru Murakami, Souichirou Yamasaki, Kenji Kariya, Kenji Morinaka, Kazuaki Chayama
Pages: 73-80
Published online on: 01 January 2004

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Article

Occult neoplastic cells in the lymph node sinuses and recurrence of primary breast, lung, esophageal, and gastric cancer

Masaya Mukai, Shinkichi Sato, Hisao Nakasaki, Takayuki Tajima, Yuuki Saito, Noboru Nishiumi, Masayuki Iwasaki, Yutaka Tokuda, Kyoji Ogoshi, Hiroshi Inoue, Hiroyasu Makuuchi
Pages: 81-84
Published online on: 01 January 2004

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Article

Hot water soluble sesquiterpenes [anhydroperoxy-costunolide and 3-oxoeudesma-1,4(15),11(13)triene-12,6α-olide] isolated from laurel (Laurus nobilis L.) induce cell death and morphological change indicative of apoptotic chromatin condensation in leukemia cells

Takashi Komiya, Yayoi Yamada, Hiroyuki Moteki, Hirotaka Katsuzaki, Kunio Imai, Hiroshige Hibasami
Pages: 85-88
Published online on: 01 January 2004

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Case Report

Characterization of a highly aberrant plasma cell leukemia karyotype: A case report

Anita Heller, Hans-Joerg Fricke, Heike Starke, Ivan F. Loncarevic, Uwe Claussen, Thomas Liehr
Pages: 89-92
Published online on: 01 January 2004

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Article

Thalidomide prolongs disease stabilization after conventional therapy in patients with recurrent glioblastoma

Alessandro Morabito, Massimo Fanelli, Guido Carillio, Domenico Gattuso, Roberta Sarmiento, Giampietro Gasparini
Pages: 93-95
Published online on: 01 January 2004

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Article

Safety and efficacy of concurrent interstitial radiation and hyperthermia in the treatment of progressive malignant brain tumors

Prithvi Narayan, Ian Crocker, Eric Elder, Jeffrey J. Olson
Pages: 97-103
Published online on: 01 January 2004

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Article

Combination therapy with radiofrequency ablation and transcatheter chemoembolization for the treatment of hepatocellular carcinoma: Short-term recurrences and survival

Koichiro Yamakado, Atsuhiro Nakatsuka, Masao Akeboshi, Katsuya Shiraki, Takeshi Nakano, Kan Takeda
Pages: 105-109
Published online on: 01 January 2004

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Article

Role of surgery in local treatment of Ewing's sarcoma of the extremities in patients undergoing adjuvant and neoadjuvant chemotherapy

Gaetano Bacci, Stefano Ferrari, Alessandra Longhi, Davide Donati, Enza Barbieri, Cristiana Forni, Franco Bertoni, Marco Manfrini, Stefano Giacomini, Patrizia Bacchini
Pages: 111-120
Published online on: 01 January 2004

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Article

Nuclear accumulation of β-catenin without an additional somatic mutation in coding region of the APC gene in hepatoblastoma from a familial adenomatous polyposis patient

Takeshi Inukai, Keiji Furuuchi, Kanji Sugita, Kanako Uno, Akishi Ooi, Fumiaki Sasaki, Jun-Ichi Hamada, Tetsuya Moriuchi, Shinpei Nakazawa
Pages: 121-126
Published online on: 01 January 2004

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Article

Differential alternative splicing expressions of telomerase reverse transcriptase in gastrointestinal cell lines

Kumi Nagao, Kenji Katsumata, Yoshio Aizawa, Noboru Saito, Hiroyuki Hirata, Hiroshi Sasaki, Shigeki Yamamoto, Kazumasa Hikiji, Tsukasa Koiwa, Hisashi Hisatomi
Pages: 127-131
Published online on: 01 January 2004

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Article

Expression of the IAPs in multidrug resistant tumor cells

Monica Notarbartolo, Melchiorre Cervello, Paola Poma, Luisa Dusonchet, Maria Meli, Natale D'Alessandro
Pages: 133-136
Published online on: 01 January 2004

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Article

No evidence for mutation of B-RAF in urothelial carcinomas of the bladder and upper urinary tract

Robert Stoehr, Anke Brinkmann, Thomas Filbeck, Christoph Gamper, Peter Wild, Hagen Blaszyk, Ferdinand Hofstaedter, Ruth Knuechel, Arndt Hartmann
Pages: 137-141
Published online on: 01 January 2004

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Article

Surrounding muscle edema detected by MRI is valuable for diagnosis of intramuscular myxoma

Kazuto Nishimoto, Katsuyuki Kusuzaki, Akihiko Matsumine, Masashi Seto, Kazuo Fukutome, Masayuki Maeda, Satoshi Hosoi, Atsumasa Uchida
Pages: 143-148
Published online on: 01 January 2004

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Article

Efficacy of boron neutron capture therapy on liver metastases of colon adenocarcinoma: Optical and ultrastructural study in the rat

Rosanna Nano, Sergio Barni, Patrizia Chiari, Tazio Pinelli, Francesca Fossati, Saverio Altieri, Cecilia Zonta, Ubaldo Prati, Laura Roveda, Aris Zonta
Pages: 149-153
Published online on: 01 January 2004

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Article

Intratumoral injection of arsenic to enhance antitumor efficacy in human esophageal carcinoma cell xenografts

Zhong-Ying Shen, Yuan Zhang, Jiong-Yu Chen, Ming-Hua Chen, Jian Shen, Wen-Hong Luo, Yi Zeng
Pages: 155-159
Published online on: 01 January 2004

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Article

Role of v-Raf and truncated form RAF1 in the induction of vascular endothelial growth factor and vascularization

Maciej Malecki, Magdalena Seneta, Joanna Miloszewska, Halina Trembacz, Malgorzata Przybyszewska, Przemyslaw Janik
Pages: 161-165
Published online on: 01 January 2004

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Article

Combined treatment with selective cyclooxygenase-2 inhibitor and fluorinated pyrimidines for liver metastasis of colon cancer

Nobuo Matsunaga, Nobuya Yamada, Masaichi Ohira, Akiko Tachimori, Yukio Nishiguchi, Hiroji Nishino, Syuichi Seki, Kosei Hirakawa
Pages: 167-171
Published online on: 01 January 2004

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Article

A simple method for the simultaneous detection of E1A and E1B in adenovirus stocks

Erika Suzuki, Takehide Murata, Sanae Watanabe, Yukari Kujime, Megumi Hirose, Jianzhi Pan, Takahito Yamazaki, Hideyo Ugai, Kazunari K. Yokoyama
Pages: 173-178
Published online on: 01 January 2004

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Article

Expression of multidrug resistance-1 and multidrug resistance-associated protein genes in pediatric rhabdomyosarcoma

Soledad Gallego, Anna Llort, Andreu Parareda, José Sanchez de Toledo
Pages: 179-183
Published online on: 01 January 2004

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Article

Hypomagnesemia associated with chemotherapy in patients treated for acute lymphoblastic leukemia: Possible mechanisms

Chun-Yuan Guo, Jacqueline M. Halton, Ronald D. Barr, Stephanie A. Atkinson
Pages: 185-189
Published online on: 01 January 2004

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Article

N-/C-terminal deleted mutant of human endostatin efficiently acts as an anti-angiogenic and anti-tumorigenic agent

Heeyeong Cho, Woo Jean Kim, You Mie Lee, Young-Mi Kim, Young-Guen Kwon, Yong Suk Park, Eu-Yul Choi, Kyu-Won Kim
Pages: 191-195
Published online on: 01 January 2004

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Article

Association of serum IL-6 levels with comprehensive geriatric assessment variables in a population of elderly cancer patients

Giovanni Mantovani, Clelia Madeddu, Giulia Gramignano, Luca Ferreli, Elena Massa, Paolo Contu, Roberto Serpe
Pages: 197-206
Published online on: 01 January 2004

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Article

Chromosome 10 and 17 deletions and p53 gene mutations in Thai patients with astrocytomas

Supawadee Put-Ti-Noi, Songsak Petmitr, Voravut Chanyavanich, Tumtip Sangruji, Veerasak Theerapuncharoen, Kenshi Hayashi, Wipawan Thangnipon
Pages: 207-211
Published online on: 01 January 2004

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Article

Combined effect of aloe-emodin and chemotherapeutic agents on the proliferation of an adherent variant cell line of Merkel cell carcinoma

Eyal Fenig, Jardena Nordenberg, Einat Beery, Jaqueline Sulkes, Lina Wasserman
Pages: 213-217
Published online on: 01 January 2004

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Article

Androgen receptor versus erbB-1 and erbB-2 expression in human prostate neoplasms

Magdalena Brys, Magdalena Stawinska, Marek Foksinski, Andrzej Barecki, Cezary Zydek, Eugeniusz Miekos, Wanda M. Krajewska
Pages: 219-224
Published online on: 01 January 2004

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Article

Synergistic action of piroxicam on the eicosapentaenoic acid-induced apoptosis is associated with enhanced down-regulation of anti-apoptotic Bcl-2 expression but not promoted activation of pro-apoptotic Bid protein

Lawrence C.-M. Chiu, K.-F. Tong, Vincent E.C. Ooi
Pages: 225-230
Published online on: 01 January 2004

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Article

Alterations of transforming growth factor β receptor II, insulin growth factor receptor II genes in microsatellite unstable prostate carcinomas

Nandan Bhattacharyya, Jianming Tao, Eric A. Klein, Sipra Banerjee
Pages: 231-236
Published online on: 01 January 2004

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Article

Endovascular lung perfusion using high-dose cisplatin: Uptake and DNA adduct formation in an animal model

Daniel B. Brown, Margaret K. Ma, Richard J. Battafarano, Sailen Naidu, Dick Pluim, William C. Zamboni, Howard L. McLeod
Pages: 237-243
Published online on: 01 January 2004

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Article

Detection of telomerase RNA in the plasma of patients with breast cancer, malignant melanoma or thyroid cancer

Srdjan Novakovic, Marko Hocevar, Janez Zgajnar, Nikola Besic, Vida Stegel
Pages: 245-252
Published online on: 01 January 2004

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Article

Analysis of the RNA helicase A gene in human lung cancer

Xiao Wei, Manuela Pacyna-Gengelbach, Karsten Schlüns, Qian An, Yanning Gao, Shujun Cheng, Iver Petersen
Pages: 253-258
Published online on: 01 January 2004

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Journal Cover
June-2026 Volume 55 Issue 6

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

E3 ubiquitin ligase RNF40: Structure, function and its context‑dependent roles in tumorigenesis (Review)

Zikun Wu, Hang Yang, Guanglong Chen, Weijie Zhao, Banghe Bao, Chai Luv, Wenpu Zhu, Faqiang Liu, Huihan Ai, Zhi Li
Article Number: 121
Published online on: 28 April 2026

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Expression of Concern Open Access

[Expression of Concern] Promoter methylation of death‑associated protein kinase and its role in irradiation response in cervical cancer

Rebecca Ching‑yu Leung, Stephanie Si Liu, Kelvin Yuen‑kwong Chan, Kar-Fai Tam, Kar-Loen Chan, Ling-Chui Wong, Hextan Yuen‑sheung Ngan
Article Number: 120
Published online on: 27 April 2026

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Article Open Access

Hypermethylation‑induced silencing of ITGA4 promotes oral squamous cell carcinoma progression through SNX5 upregulation

Nguyen Ngoc Thuy Tien, Han-Cheol Choe, Sang-Gun Ahn
Article Number: 119
Published online on: 24 April 2026

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Expression of Concern Open Access

[Expression of Concern] Pifithrin‑μ is efficacious against non‑small cell lung cancer via inhibition of heat shock protein 70

Yang Zhou, Jingping Ma, Jiahong Zhang, Li He, Jianhua Gong, Cong Long
Article Number: 118
Published online on: 22 April 2026

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Article Open Access

Inhibitory role of angiopoietin‑like 4 for cancer progression in oropharyngeal squamous cell carcinoma

Takuya Mikoshiba, Mariko Sekimizu, Nana Nakahara, Shin Saito, Keisuke Yoshihama, Ryoto Nagai, Takeyuki Kono, Hiroyuki Ozawa
Article Number: 117
Published online on: 20 April 2026

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Expression of Concern Open Access

[Expression of Concern] Adenovirus‑mediated truncated Bid overexpression induced by the Cre/LoxP system promotes the cell apoptosis of CD133+ ovarian cancer stem cells

Qifang Long, Ru Yang, Weixian Lu, Weipei Zhu, Jundong Zhou, Cui Zheng, Dongmei Zhou, Ling Yu, Jinchang Wu
Article Number: 116
Published online on: 15 April 2026

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Review Open Access

Incorporating artificial intelligence into morphological diagnosis of acute leukemias: Current landscape, challenges and prospects (Review)

Hui Cheng, Guodong Zheng, Yuanyuan Yang, Chun Xu, Gusheng Tang, Chongmei Huang
Article Number: 115
Published online on: 15 April 2026

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Article Open Access

Mechanistic study of MUC3A in promoting progression of clear cell renal cell carcinoma via the JAK‑STAT pathway

Yongyang Yun, Xing Ji, Shuai Hu, Tianyu Wu, Yixiao Liu, Zheng Li, Zhoujie Sun, Peimin Zhou, Lei Yang, Wei Yu
Article Number: 114
Published online on: 14 April 2026

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Article Open Access

Perturbation of BRD4 and p300 activity suppresses super enhancer‑driven KLF6 expression in renal carcinoma

Nurul Nadia Mohamad Zamberi, Asmaa Y. Abuhamad, Siti Nur Hasanah Mohd Yusuf, Nur Qurratu Athirah A. Rahman, Mohamad Aimanuddin Mohtar, Saiful Effendi Syafruddin
Article Number: 113
Published online on: 14 April 2026

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Article Open Access

PINK1‑mediated mitophagy enhances breast cancer proliferation through metabolic reprogramming

Zong Jin Guo, Qian Yu, Rui Sha, Wei Li, Hui Juan Dai
Article Number: 112
Published online on: 14 April 2026

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Expression of Concern Open Access

[Expression of Concern] Metformin inhibits growth and sensitizes osteosarcoma cell lines to cisplatin through cell cycle modulation

Irene Quattrini, Amalia Conti, Laura Pazzaglia, Chiara Novello, Stefano Ferrari, Piero Picci, Maria Serena Benassi
Article Number: 111
Published online on: 08 April 2026

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Article Open Access

NF‑κB‑driven LUZP1 promotes metastasis and chemoresistance in head and neck squamous cell carcinoma

Chen-Yuan Lin, Ching-Yun Hsieh, Hsin-Chi Lan, Ching-Chan Lin, Tzu-Ting Chen, Wei-Chi Tseng, Yung-An Tsou, Wei-Chao Chang
Article Number: 110
Published online on: 07 April 2026

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Article Open Access

Hypoxic CAF studies unveil PTHrP‑vitamin D‑RAS axis as pivotal in the CAF

Shoichiro Nakajo, Mamoru Uemura, Hiroshi Kusafuka, Mao Osaki, Chikako Kusunoki, Nobuo Takiguchi, Mitsunobu Takeda, Yuki Sekido, Tsuyoshi Hata, Atsushi Hamabe, Takayuki Ogino, Norikatsu Miyoshi, Mitsuyoshi Tei, Yoshinori Kagawa, Hirofumi Yamamoto, Yuichiro Doki, Hidetoshi Eguchi
Article Number: 109
Published online on: 07 April 2026

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Retraction Open Access

[Retracted] miR‑24‑3p regulates bladder cancer cell proliferation, migration, invasion and autophagy by targeting DEDD

Guoqiang Yu, Zhaohui Jia, Zhongling Dou
Article Number: 108
Published online on: 06 April 2026

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Review Open Access

Role of CHD4 in tumor progression, DNA damage response and treatment resistance (Review)

Shuo Li, Quan Ma, Keying Lian, Zhisheng Jiang, Yun Ma
Article Number: 107
Published online on: 02 April 2026

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Review Open Access

T cell fate regulation in EBV‑associated nasopharyngeal carcinoma (Review)

Liuyang Zhang, Shun Ding, Dongzhui Chen, Benchi Cai, Zhonglin Mu
Article Number: 106
Published online on: 02 April 2026

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Retraction Open Access

[Retracted] Ultrasound‑targeted microbubble destruction‑mediated overexpression of Sirtuin 3 inhibits the progression of ovarian cancer

Li Cheng, Dongmei Zhang, Wei Yan
Article Number: 105
Published online on: 02 April 2026

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Review Open Access

HMGB3: A pivotal orchestrator of therapy resistance and cancer stemness in human malignancies (Review)

Ju Zhang, Yifan Sun, Lanyu Wang, Jiayu Gu, Ye Hua, Jianfeng Shao, Ninghan Feng
Article Number: 104
Published online on: 01 April 2026

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Expression of Concern Open Access

[Expression of Concern] 5‑Azacytidine inhibits the proliferation of bladder cancer cells via reversal of the aberrant hypermethylation of the hepaCAM gene

Xiaorong Wang, E. Chen, Xue Yang, Yin Wang, Zhen Quan, Xiaohou Wu, Chunli Luo
Article Number: 103
Published online on: 30 March 2026

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July-2026 Volume 56 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Retraction Open Access

[Retracted] PTEN enhances G2/M arrest in etoposide‑treated MCF‑7 cells through activation of the ATM pathway

Ruopeng Zhang, Li Zhu, Lirong Zhang, Anli Xu, Zhengwei Li, Yijuan Xu, Pei He, Maoqing Wu, Fengxiang Wei, Chenhong Wang
Article Number: 122
Published online on: 29 April 2026

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