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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2004 Volume 11 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2004 Volume 11 Issue 1

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Article

Expression of multidrug resistance-1 and multidrug resistance-associated protein genes in pediatric rhabdomyosarcoma

  • Authors:
    • Soledad Gallego
    • Anna Llort
    • Andreu Parareda
    • José Sanchez de Toledo

  • View Affiliations / Copyright

    Affiliations: Unitat d'Oncologia Pediàtrica, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain. sgallego@vhebron.net
  • Pages: 179-183
    |
    Published online on: January 1, 2004
       https://doi.org/10.3892/or.11.1.179
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Abstract

Overexpression of multidrug resistance-1 (MDR-1), and multidrug resistance-associated protein (MRP) genes has been linked with resistance to chemotherapy in vitro and in vivo. Their role in chemotherapy resistance in pediatric rhabdomyosarcoma is unclear. The study was undertaken to analyze the expression of MDR-1 and MRP genes in the embryonal and the alveolar subtypes of rhabdomyosarcoma and to elucidate its clinical relevance. Twenty-three rhabdomyosarcoma samples were analyzed for the expression of MDR-1 and MRP genes using a semi-quantitative competitive RT-PCR assay. MRP gene expression was associated with a reduction in survival (p=0.02). The overall survival of patients with tumors positive or negative for MRP expression were 50% (95% confidence interval, 30-70%) and 93% (95% confidence interval, 76-100%) respectively. In contrast, the expression of MDR-1 gene was not predictive of survival. These findings suggest that MRP expression could be a prognostic factor in patients with rhabdomyosarcoma.

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Copy and paste a formatted citation
Spandidos Publications style
Gallego S, Llort A, Parareda A and Sanchez de Toledo J: Expression of multidrug resistance-1 and multidrug resistance-associated protein genes in pediatric rhabdomyosarcoma. Oncol Rep 11: 179-183, 2004.
APA
Gallego, S., Llort, A., Parareda, A., & Sanchez de Toledo, J. (2004). Expression of multidrug resistance-1 and multidrug resistance-associated protein genes in pediatric rhabdomyosarcoma. Oncology Reports, 11, 179-183. https://doi.org/10.3892/or.11.1.179
MLA
Gallego, S., Llort, A., Parareda, A., Sanchez de Toledo, J."Expression of multidrug resistance-1 and multidrug resistance-associated protein genes in pediatric rhabdomyosarcoma". Oncology Reports 11.1 (2004): 179-183.
Chicago
Gallego, S., Llort, A., Parareda, A., Sanchez de Toledo, J."Expression of multidrug resistance-1 and multidrug resistance-associated protein genes in pediatric rhabdomyosarcoma". Oncology Reports 11, no. 1 (2004): 179-183. https://doi.org/10.3892/or.11.1.179
Copy and paste a formatted citation
x
Spandidos Publications style
Gallego S, Llort A, Parareda A and Sanchez de Toledo J: Expression of multidrug resistance-1 and multidrug resistance-associated protein genes in pediatric rhabdomyosarcoma. Oncol Rep 11: 179-183, 2004.
APA
Gallego, S., Llort, A., Parareda, A., & Sanchez de Toledo, J. (2004). Expression of multidrug resistance-1 and multidrug resistance-associated protein genes in pediatric rhabdomyosarcoma. Oncology Reports, 11, 179-183. https://doi.org/10.3892/or.11.1.179
MLA
Gallego, S., Llort, A., Parareda, A., Sanchez de Toledo, J."Expression of multidrug resistance-1 and multidrug resistance-associated protein genes in pediatric rhabdomyosarcoma". Oncology Reports 11.1 (2004): 179-183.
Chicago
Gallego, S., Llort, A., Parareda, A., Sanchez de Toledo, J."Expression of multidrug resistance-1 and multidrug resistance-associated protein genes in pediatric rhabdomyosarcoma". Oncology Reports 11, no. 1 (2004): 179-183. https://doi.org/10.3892/or.11.1.179
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