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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2004 Volume 11 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2004 Volume 11 Issue 1

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Article

Alterations of transforming growth factor β receptor II, insulin growth factor receptor II genes in microsatellite unstable prostate carcinomas

  • Authors:
    • Nandan Bhattacharyya
    • Jianming Tao
    • Eric A. Klein
    • Sipra Banerjee

  • View Affiliations / Copyright

    Affiliations: Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA. bhattan@ccf.org
  • Pages: 231-236
    |
    Published online on: January 1, 2004
       https://doi.org/10.3892/or.11.1.231
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Abstract

DNA from 45 primary prostate tumors and corresponding normal tissues were analyzed to detect whether the alterations of transforming growth factor β receptor II (TGFβRII) and insulin growth factor receptor II (IGFRII) are associated with microsatellite instability (MSI). We identified that 25 tumors were microsatellite unstable (55%). The remaining 20 tumors are found to be microsatellite stable. Loss of heterozygosity (LOH) was also tested at various loci. Results indicate that in case of TGFβRII, the rate of frame-shift mutation depends on the number of polyadenine [poly(A)] tracts. Twelve percent of the tumors had frame-shift alteration at BAT-RII locus which has 10 poly(A) repeats. Twenty percent of the tumors had frame-shift at BAT-25 locus which has 25 poly(A) repeats. In addition, IGFRII gene was examined for the presence of mutation in the repetitive sequences. Seven of the 25 tumors showed deletion of a G within eight poly(G) repeats. Besides these changes there were two tumors which showed a novel insertion of A within this poly(G) repeat making a change in 9 samples (R4, 36%). On the other hand, 4 tumors showed changes within the 5CT repeats. In addition, 3 tumors showed another novel insertion of C within the CT repeats.

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Copy and paste a formatted citation
Spandidos Publications style
Bhattacharyya N, Tao J, Klein EA and Banerjee S: Alterations of transforming growth factor β receptor II, insulin growth factor receptor II genes in microsatellite unstable prostate carcinomas. Oncol Rep 11: 231-236, 2004.
APA
Bhattacharyya, N., Tao, J., Klein, E.A., & Banerjee, S. (2004). Alterations of transforming growth factor β receptor II, insulin growth factor receptor II genes in microsatellite unstable prostate carcinomas. Oncology Reports, 11, 231-236. https://doi.org/10.3892/or.11.1.231
MLA
Bhattacharyya, N., Tao, J., Klein, E. A., Banerjee, S."Alterations of transforming growth factor β receptor II, insulin growth factor receptor II genes in microsatellite unstable prostate carcinomas". Oncology Reports 11.1 (2004): 231-236.
Chicago
Bhattacharyya, N., Tao, J., Klein, E. A., Banerjee, S."Alterations of transforming growth factor β receptor II, insulin growth factor receptor II genes in microsatellite unstable prostate carcinomas". Oncology Reports 11, no. 1 (2004): 231-236. https://doi.org/10.3892/or.11.1.231
Copy and paste a formatted citation
x
Spandidos Publications style
Bhattacharyya N, Tao J, Klein EA and Banerjee S: Alterations of transforming growth factor β receptor II, insulin growth factor receptor II genes in microsatellite unstable prostate carcinomas. Oncol Rep 11: 231-236, 2004.
APA
Bhattacharyya, N., Tao, J., Klein, E.A., & Banerjee, S. (2004). Alterations of transforming growth factor β receptor II, insulin growth factor receptor II genes in microsatellite unstable prostate carcinomas. Oncology Reports, 11, 231-236. https://doi.org/10.3892/or.11.1.231
MLA
Bhattacharyya, N., Tao, J., Klein, E. A., Banerjee, S."Alterations of transforming growth factor β receptor II, insulin growth factor receptor II genes in microsatellite unstable prostate carcinomas". Oncology Reports 11.1 (2004): 231-236.
Chicago
Bhattacharyya, N., Tao, J., Klein, E. A., Banerjee, S."Alterations of transforming growth factor β receptor II, insulin growth factor receptor II genes in microsatellite unstable prostate carcinomas". Oncology Reports 11, no. 1 (2004): 231-236. https://doi.org/10.3892/or.11.1.231
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