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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2004 Volume 11 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2004 Volume 11 Issue 1

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Article

Safety and efficacy of concurrent interstitial radiation and hyperthermia in the treatment of progressive malignant brain tumors

  • Authors:
    • Prithvi Narayan
    • Ian Crocker
    • Eric Elder
    • Jeffrey J. Olson

  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Emory University, Atlanta, GA 30322, USA
  • Pages: 97-103
    |
    Published online on: January 1, 2004
       https://doi.org/10.3892/or.11.1.97
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Abstract

High activity 125I brachytherapy has efficacy in selected recurrent malignant brain tumors, but limited efficacy and risk of radiation necrosis have prompted investigation of additional adjunctive therapies. This study aims to assess the toxicity of interstitial conductive hyperthermia used concurrently with 125I brachytherapy for the treatment of recurrent brain malignancies. Twelve patients with recurrent malignant brain tumors were implanted using afterloading catheters intended to deliver 50 Gy at the isodose line encompassing the enhancing tumor with a 5-mm margin and heated to 41.5°C for 48 h. The average implant volume was 18 cc with 5.3 catheters containing 9.4 sources with a total activity of 265 mCi. Serious toxicities included 8 motor deficits, 2 mood alterations, 4 seizures and 2 catheter wound cerebrospinal fluid leaks. Median survival was 10.35 months with the best responses being 6 with stable disease and 2 with partial responses. Reoperation rate for radiation necrosis was 33%. Concurrent conductive thermoradiotherapy is feasible but is associated with serious toxicity. There is no suggestion of improved survival with thermoradiotherapy over brachytherapy alone. Given the degree of toxicity observed, alternative approaches to improving local control of these tumors are being explored.

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Copy and paste a formatted citation
Spandidos Publications style
Narayan P, Crocker I, Elder E and Olson JJ: Safety and efficacy of concurrent interstitial radiation and hyperthermia in the treatment of progressive malignant brain tumors. Oncol Rep 11: 97-103, 2004.
APA
Narayan, P., Crocker, I., Elder, E., & Olson, J.J. (2004). Safety and efficacy of concurrent interstitial radiation and hyperthermia in the treatment of progressive malignant brain tumors. Oncology Reports, 11, 97-103. https://doi.org/10.3892/or.11.1.97
MLA
Narayan, P., Crocker, I., Elder, E., Olson, J. J."Safety and efficacy of concurrent interstitial radiation and hyperthermia in the treatment of progressive malignant brain tumors". Oncology Reports 11.1 (2004): 97-103.
Chicago
Narayan, P., Crocker, I., Elder, E., Olson, J. J."Safety and efficacy of concurrent interstitial radiation and hyperthermia in the treatment of progressive malignant brain tumors". Oncology Reports 11, no. 1 (2004): 97-103. https://doi.org/10.3892/or.11.1.97
Copy and paste a formatted citation
x
Spandidos Publications style
Narayan P, Crocker I, Elder E and Olson JJ: Safety and efficacy of concurrent interstitial radiation and hyperthermia in the treatment of progressive malignant brain tumors. Oncol Rep 11: 97-103, 2004.
APA
Narayan, P., Crocker, I., Elder, E., & Olson, J.J. (2004). Safety and efficacy of concurrent interstitial radiation and hyperthermia in the treatment of progressive malignant brain tumors. Oncology Reports, 11, 97-103. https://doi.org/10.3892/or.11.1.97
MLA
Narayan, P., Crocker, I., Elder, E., Olson, J. J."Safety and efficacy of concurrent interstitial radiation and hyperthermia in the treatment of progressive malignant brain tumors". Oncology Reports 11.1 (2004): 97-103.
Chicago
Narayan, P., Crocker, I., Elder, E., Olson, J. J."Safety and efficacy of concurrent interstitial radiation and hyperthermia in the treatment of progressive malignant brain tumors". Oncology Reports 11, no. 1 (2004): 97-103. https://doi.org/10.3892/or.11.1.97
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