Intracranial inhibition of glioma cell growth by cyclooxygenase-2 inhibitor celecoxib

  • Authors:
    • Do-Hyun Nam
    • Kwan Park
    • Chaehwa Park
    • Young-Hyuck Im
    • Mi-Hyun Kim
    • Sangjun Lee
    • Seung-Chyul Hong
    • Hyung-Jin Shin
    • Jong-Hyun Kim
    • Whan Eoh
    • Timothy J. McDonnell
  • View Affiliations

  • Published online on: February 1, 2004     https://doi.org/10.3892/or.11.2.263
  • Pages: 263-268
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Abstract

Higher cyclooxygenase-2 (COX-2) expression is clinically associated with more aggressive gliomas and is a strong predictor of poor survival. To determine whether oral administration of a COX-2-specific inhibitor can inhibit glial tumors, we analyzed the effect of celecoxib on the growth of 9L rat gliosarcoma cells that were orthotopically transplanted into rat brains. Oral administration of celecoxib beginning 1 day after implantation of 5x104 9L rat gliosarcoma cells into rat brain reduced the incidence and size of tumors significantly. Immunohistochemical analysis of implanted gliosarcoma cells from rats treated with celecoxib showed lower levels of phospho-Akt, phospho-EGFR, Bcl-2, and Bcl-XL expression compared with untreated tumor cells. Gliosarcoma cells from treated rats had significantly more TUNEL- and caspase-3-positive cells and fewer PCNA-positive cells. These results demonstrate that selective COX-2 inhibitors may be useful as adjuvants and/or therapeutic agents to treat gliomas overexpressing COX-2.

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February 2004
Volume 11 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Nam D, Park K, Park C, Im Y, Kim M, Lee S, Hong S, Shin H, Kim J, Eoh W, Eoh W, et al: Intracranial inhibition of glioma cell growth by cyclooxygenase-2 inhibitor celecoxib. Oncol Rep 11: 263-268, 2004.
APA
Nam, D., Park, K., Park, C., Im, Y., Kim, M., Lee, S. ... McDonnell, T.J. (2004). Intracranial inhibition of glioma cell growth by cyclooxygenase-2 inhibitor celecoxib. Oncology Reports, 11, 263-268. https://doi.org/10.3892/or.11.2.263
MLA
Nam, D., Park, K., Park, C., Im, Y., Kim, M., Lee, S., Hong, S., Shin, H., Kim, J., Eoh, W., McDonnell, T. J."Intracranial inhibition of glioma cell growth by cyclooxygenase-2 inhibitor celecoxib". Oncology Reports 11.2 (2004): 263-268.
Chicago
Nam, D., Park, K., Park, C., Im, Y., Kim, M., Lee, S., Hong, S., Shin, H., Kim, J., Eoh, W., McDonnell, T. J."Intracranial inhibition of glioma cell growth by cyclooxygenase-2 inhibitor celecoxib". Oncology Reports 11, no. 2 (2004): 263-268. https://doi.org/10.3892/or.11.2.263