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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2004 Volume 11 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Imprint cytologic features of pulmonary large cell neuroendocrine carcinoma: Comparison with classic large cell carcinoma

  • Authors:
    • Akira Iyoda
    • Masayuki Baba
    • Kenzo Hiroshima
    • Hiroko Saitoh
    • Yasumitsu Moriya
    • Kiyoshi Shibuya
    • Toshihiko Iizasa
    • Fumio Horiuchi
    • Hidemi Ohwada
    • Takehiko Fujisawa

  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan
  • Pages: 285-288
    |
    Published online on: February 1, 2004
       https://doi.org/10.3892/or.11.2.285
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Abstract

The World Health Organization (WHO) categorized large cell neuroendocrine carcinoma (LCNEC) as a variant of large cell carcinoma in 1999. However, cytologic features of these tumors have not yet been adequately characterized. The cytologic features of 24 cases of LCNEC were analyzed and compared to the features of 16 cases of classic large cell carcinoma (CLCC). Giant cells, neutrophils and cytophagocytosis were observed more frequently in CLCC than in LCNEC (p<0.05), whereas the unclear border of tumor cells was seen more frequently in LCNEC (p<0.05). The presence of nuclear atypia, such as anisokaryosis, nuclear budding, irregularity of nuclear margins, and multinucleation (having three or more nuclei), was observed less frequently in LCNEC. Characteristic arrangements of tumor cells, such as rosette formation, and palisading, were observed only in LCNEC cases. In morphometric studies, the nuclear areas, cytoplasmic areas, and nuclear rotundity ratios were significantly higher in CLCC cells than in LCNEC cells (p<0.05). However, N/C ratios were significantly higher in LCNEC than in CLCC. LCNEC cells have less nuclear atypia than CLCC cells, and have the characteristic arrangements of tumor cells, such as palisading and rosette. It is possible to preoperatively differentiate LCNEC from CLCC by careful cytologic characterization.

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Copy and paste a formatted citation
Spandidos Publications style
Iyoda A, Baba M, Hiroshima K, Saitoh H, Moriya Y, Shibuya K, Iizasa T, Horiuchi F, Ohwada H, Fujisawa T, Fujisawa T, et al: Imprint cytologic features of pulmonary large cell neuroendocrine carcinoma: Comparison with classic large cell carcinoma. Oncol Rep 11: 285-288, 2004.
APA
Iyoda, A., Baba, M., Hiroshima, K., Saitoh, H., Moriya, Y., Shibuya, K. ... Fujisawa, T. (2004). Imprint cytologic features of pulmonary large cell neuroendocrine carcinoma: Comparison with classic large cell carcinoma. Oncology Reports, 11, 285-288. https://doi.org/10.3892/or.11.2.285
MLA
Iyoda, A., Baba, M., Hiroshima, K., Saitoh, H., Moriya, Y., Shibuya, K., Iizasa, T., Horiuchi, F., Ohwada, H., Fujisawa, T."Imprint cytologic features of pulmonary large cell neuroendocrine carcinoma: Comparison with classic large cell carcinoma". Oncology Reports 11.2 (2004): 285-288.
Chicago
Iyoda, A., Baba, M., Hiroshima, K., Saitoh, H., Moriya, Y., Shibuya, K., Iizasa, T., Horiuchi, F., Ohwada, H., Fujisawa, T."Imprint cytologic features of pulmonary large cell neuroendocrine carcinoma: Comparison with classic large cell carcinoma". Oncology Reports 11, no. 2 (2004): 285-288. https://doi.org/10.3892/or.11.2.285
Copy and paste a formatted citation
x
Spandidos Publications style
Iyoda A, Baba M, Hiroshima K, Saitoh H, Moriya Y, Shibuya K, Iizasa T, Horiuchi F, Ohwada H, Fujisawa T, Fujisawa T, et al: Imprint cytologic features of pulmonary large cell neuroendocrine carcinoma: Comparison with classic large cell carcinoma. Oncol Rep 11: 285-288, 2004.
APA
Iyoda, A., Baba, M., Hiroshima, K., Saitoh, H., Moriya, Y., Shibuya, K. ... Fujisawa, T. (2004). Imprint cytologic features of pulmonary large cell neuroendocrine carcinoma: Comparison with classic large cell carcinoma. Oncology Reports, 11, 285-288. https://doi.org/10.3892/or.11.2.285
MLA
Iyoda, A., Baba, M., Hiroshima, K., Saitoh, H., Moriya, Y., Shibuya, K., Iizasa, T., Horiuchi, F., Ohwada, H., Fujisawa, T."Imprint cytologic features of pulmonary large cell neuroendocrine carcinoma: Comparison with classic large cell carcinoma". Oncology Reports 11.2 (2004): 285-288.
Chicago
Iyoda, A., Baba, M., Hiroshima, K., Saitoh, H., Moriya, Y., Shibuya, K., Iizasa, T., Horiuchi, F., Ohwada, H., Fujisawa, T."Imprint cytologic features of pulmonary large cell neuroendocrine carcinoma: Comparison with classic large cell carcinoma". Oncology Reports 11, no. 2 (2004): 285-288. https://doi.org/10.3892/or.11.2.285
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