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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2004 Volume 11 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2004 Volume 11 Issue 2

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Article

Regulation of squamous cell carcinoma antigen production by E-cadherin mediated cell-cell adhesion in squamous cell carcinoma cell line

  • Authors:
    • Hiroshi Hirakawa
    • Shugo Nawata
    • Kotaro Sueoka
    • Akihiro Murakami
    • Osamu Takeda
    • Fumitaka Numa
    • Hiroshi Kato
    • Norihiro Sugino

  • View Affiliations / Copyright

    Affiliations: Division of Obstetrics and Gynecology, Department of Reproductive Pediatric and Infectious Science, Yamaguchi University School of Medicine, Ube, Japan
  • Pages: 415-419
    |
    Published online on: February 1, 2004
       https://doi.org/10.3892/or.11.2.415
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Abstract

Squamous cell carcinoma antigen (SCCA) is a useful tumor marker for diagnosis and management of squamous cell carcinoma. It is well known that cell-cell adhesion is important for progression of cancer. However, it is not clarified whether cell-cell adhesion affects SCCA production in squamous cell carcinoma. The present study was, therefore, undertaken to investigate whether E-cadherin-mediated cell-cell adhesion affects SCCA production in squamous cell carcinoma of the uterine cervix. SKG-IIIa cells or CaSki cells, cervical squamous cell carcinoma cell lines, were treated with anti-E-cadherin antibodies (1 µg/ml) up to 72 h. The cells were dissociated, and SCCA content in the cytosol and SCCA mRNA levels were significantly decreased compared to the control group treated with mouse IgG. Secondly, the signaling pathway for SCCA production mediated by E-cadherin was examined. Phosphatidylinositol (PI) 3-kinase is a well-known mediator of E-cadherin-mediated biological events. The treatment with a PI 3-kinase inhibitor suppressed SCCA production in SKG-IIIa cells. It is concluded that E-cadherin mediated cell-cell adhesion maintains SCCA production through PI 3-kinase in squamous cell carcinoma.

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Copy and paste a formatted citation
Spandidos Publications style
Hirakawa H, Nawata S, Sueoka K, Murakami A, Takeda O, Numa F, Kato H and Sugino N: Regulation of squamous cell carcinoma antigen production by E-cadherin mediated cell-cell adhesion in squamous cell carcinoma cell line. Oncol Rep 11: 415-419, 2004.
APA
Hirakawa, H., Nawata, S., Sueoka, K., Murakami, A., Takeda, O., Numa, F. ... Sugino, N. (2004). Regulation of squamous cell carcinoma antigen production by E-cadherin mediated cell-cell adhesion in squamous cell carcinoma cell line. Oncology Reports, 11, 415-419. https://doi.org/10.3892/or.11.2.415
MLA
Hirakawa, H., Nawata, S., Sueoka, K., Murakami, A., Takeda, O., Numa, F., Kato, H., Sugino, N."Regulation of squamous cell carcinoma antigen production by E-cadherin mediated cell-cell adhesion in squamous cell carcinoma cell line". Oncology Reports 11.2 (2004): 415-419.
Chicago
Hirakawa, H., Nawata, S., Sueoka, K., Murakami, A., Takeda, O., Numa, F., Kato, H., Sugino, N."Regulation of squamous cell carcinoma antigen production by E-cadherin mediated cell-cell adhesion in squamous cell carcinoma cell line". Oncology Reports 11, no. 2 (2004): 415-419. https://doi.org/10.3892/or.11.2.415
Copy and paste a formatted citation
x
Spandidos Publications style
Hirakawa H, Nawata S, Sueoka K, Murakami A, Takeda O, Numa F, Kato H and Sugino N: Regulation of squamous cell carcinoma antigen production by E-cadherin mediated cell-cell adhesion in squamous cell carcinoma cell line. Oncol Rep 11: 415-419, 2004.
APA
Hirakawa, H., Nawata, S., Sueoka, K., Murakami, A., Takeda, O., Numa, F. ... Sugino, N. (2004). Regulation of squamous cell carcinoma antigen production by E-cadherin mediated cell-cell adhesion in squamous cell carcinoma cell line. Oncology Reports, 11, 415-419. https://doi.org/10.3892/or.11.2.415
MLA
Hirakawa, H., Nawata, S., Sueoka, K., Murakami, A., Takeda, O., Numa, F., Kato, H., Sugino, N."Regulation of squamous cell carcinoma antigen production by E-cadherin mediated cell-cell adhesion in squamous cell carcinoma cell line". Oncology Reports 11.2 (2004): 415-419.
Chicago
Hirakawa, H., Nawata, S., Sueoka, K., Murakami, A., Takeda, O., Numa, F., Kato, H., Sugino, N."Regulation of squamous cell carcinoma antigen production by E-cadherin mediated cell-cell adhesion in squamous cell carcinoma cell line". Oncology Reports 11, no. 2 (2004): 415-419. https://doi.org/10.3892/or.11.2.415
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