Resveratrol inhibits cell proliferation and induces apoptosis of human breast carcinoma MCF-7 cells

  • Authors:
    • Young-Ae Kim
    • Byung Tae Choi
    • Yong Tae Lee
    • Dong Il Park
    • Sook-Hee Rhee
    • Kun-Young Park
    • Yung Hyun Choi
  • View Affiliations

  • Published online on: February 1, 2004     https://doi.org/10.3892/or.11.2.441
  • Pages: 441-446
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Abstract

Resveratrol, which is found in grapes and wine, has been reported to have a variety of important pharmacological effects including anti-inflammatory, anti-platelet, and anti-carcinogenetic properties. In this study, using the human breast cancer cell line MCF-7, we have analyzed a possible mechanism by which resveratrol could interfere with cell cycle control and induce cell death. Resveratrol treatment of MCF-7 cells resulted in a dose-dependent inhibition of the cell growth and the cells accumulated at the S phase transition of the cell cycle at low concentrations, but high concentrations do not induce S phase accumulation. The anti-proliferative effects of resveratrol were associated with a marked inhibition of cyclin D and cyclin-dependent kinase (Cdk) 4 proteins, and induction of p53 and Cdk inhibitor p21WAF1/CIP. Growth suppression by resveratrol was also due to apoptosis, as seen by the appearance of a sub-G1 fraction and chromatin condensation. In addition, the apoptotic process involves activation of caspase-9, a decrease of Bcl-2 as well as Bcl-XL levels, and an increase of Bax levels.

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February 2004
Volume 11 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Kim Y, Choi BT, Lee YT, Park DI, Rhee S, Park K and Choi YH: Resveratrol inhibits cell proliferation and induces apoptosis of human breast carcinoma MCF-7 cells. Oncol Rep 11: 441-446, 2004
APA
Kim, Y., Choi, B.T., Lee, Y.T., Park, D.I., Rhee, S., Park, K., & Choi, Y.H. (2004). Resveratrol inhibits cell proliferation and induces apoptosis of human breast carcinoma MCF-7 cells. Oncology Reports, 11, 441-446. https://doi.org/10.3892/or.11.2.441
MLA
Kim, Y., Choi, B. T., Lee, Y. T., Park, D. I., Rhee, S., Park, K., Choi, Y. H."Resveratrol inhibits cell proliferation and induces apoptosis of human breast carcinoma MCF-7 cells". Oncology Reports 11.2 (2004): 441-446.
Chicago
Kim, Y., Choi, B. T., Lee, Y. T., Park, D. I., Rhee, S., Park, K., Choi, Y. H."Resveratrol inhibits cell proliferation and induces apoptosis of human breast carcinoma MCF-7 cells". Oncology Reports 11, no. 2 (2004): 441-446. https://doi.org/10.3892/or.11.2.441