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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
February 2004 Volume 11 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2004 Volume 11 Issue 2

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Article

Arsenic trioxide-induced apoptosis is independent of CD95 in lymphatic cell lines

  • Authors:
    • Markus Thomas Rojewski
    • Sixten Körper
    • Eckhard Thiel
    • Hubert Schrezenmeier

  • View Affiliations / Copyright

    Affiliations: Universitäts-klinikum Ulm, Abteilung Transfusionsmedizin und Institut für Klinische Transfusionsmedizin und Immungenetik gGmbH, 89081 Ulm, Germany. markus.rojewski@medizin.uni-ulm.de
  • Pages: 509-513
    |
    Published online on: February 1, 2004
       https://doi.org/10.3892/or.11.2.509
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Abstract

The potency of arsenic trioxide (As2O3) as chemotherapeutic agent is under investigation in various clinical trials. As2O3 was shown to be a potent inductor of apoptosis, and several publications describe the involvement of caspases, reduction of mitochondrial membrane potential and modulation of intracellular glutathione level. However, little is known about the involvement of membrane bound cell death receptors. We investigated the role of CD95 and CD95L in As2O3 mediated apoptosis in various lympho-haematopoietic cell lines. Basal CD95-expression did not correlate with sensitivity to As2O3 and incubation with As2O3 did not alter CD95-expression. We therefore chose two CD95 positive cell lines (CCRF-CEM and Jurkat) to analyse a potential activation of this pathway. We were able to induce apoptosis in these CD95 positive cell lines with activating anti-CD95 antibodies and could block induction of apoptosis by inhibitory anti-CD95 antibodies. In contrast we were not able to block As2O3-induced apoptosis by inhibitory anti-CD95 antibodies. We could block additive effects of arsenic trioxide and an apoptosis-inducing anti-CD95 antibody against CD95 to levels of arsenic trioxide alone using an inhibitory anti-CD95 antibody. Thus, our data provide no evidence for a role of the CD95L/CD95 pathway in As2O3-induced apoptosis.

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Copy and paste a formatted citation
Spandidos Publications style
Rojewski MT, Körper S, Thiel E and Schrezenmeier H: Arsenic trioxide-induced apoptosis is independent of CD95 in lymphatic cell lines. Oncol Rep 11: 509-513, 2004.
APA
Rojewski, M.T., Körper, S., Thiel, E., & Schrezenmeier, H. (2004). Arsenic trioxide-induced apoptosis is independent of CD95 in lymphatic cell lines. Oncology Reports, 11, 509-513. https://doi.org/10.3892/or.11.2.509
MLA
Rojewski, M. T., Körper, S., Thiel, E., Schrezenmeier, H."Arsenic trioxide-induced apoptosis is independent of CD95 in lymphatic cell lines". Oncology Reports 11.2 (2004): 509-513.
Chicago
Rojewski, M. T., Körper, S., Thiel, E., Schrezenmeier, H."Arsenic trioxide-induced apoptosis is independent of CD95 in lymphatic cell lines". Oncology Reports 11, no. 2 (2004): 509-513. https://doi.org/10.3892/or.11.2.509
Copy and paste a formatted citation
x
Spandidos Publications style
Rojewski MT, Körper S, Thiel E and Schrezenmeier H: Arsenic trioxide-induced apoptosis is independent of CD95 in lymphatic cell lines. Oncol Rep 11: 509-513, 2004.
APA
Rojewski, M.T., Körper, S., Thiel, E., & Schrezenmeier, H. (2004). Arsenic trioxide-induced apoptosis is independent of CD95 in lymphatic cell lines. Oncology Reports, 11, 509-513. https://doi.org/10.3892/or.11.2.509
MLA
Rojewski, M. T., Körper, S., Thiel, E., Schrezenmeier, H."Arsenic trioxide-induced apoptosis is independent of CD95 in lymphatic cell lines". Oncology Reports 11.2 (2004): 509-513.
Chicago
Rojewski, M. T., Körper, S., Thiel, E., Schrezenmeier, H."Arsenic trioxide-induced apoptosis is independent of CD95 in lymphatic cell lines". Oncology Reports 11, no. 2 (2004): 509-513. https://doi.org/10.3892/or.11.2.509
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