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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2004 Volume 11 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2004 Volume 11 Issue 2

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Review

The role of protein kinase C-α in malignancies of the nervous system and implications for the clinical development of the specific PKC-α inhibitor aprinocarsen (Review)

  • Authors:
    • Michael M. Lahn
    • Karen L. Sundell
    • Blake M. Paterson

  • View Affiliations / Copyright

    Affiliations: Eli Lilly and Company, Oncology Product Development, Lilly Corporate Center, Indianapolis, IN 46285, USA. mlahn@lilly.com
  • Pages: 515-522
    |
    Published online on: February 1, 2004
       https://doi.org/10.3892/or.11.2.515
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Abstract

Antisense oligonucleotide (ASO) technology offers a novel approach for the development of anti-cancer drugs. For example, the ASO aprinocarsen has been developed to specifically inhibit the intracellular signal transduction protein, protein kinase C-α (PKC-α). The clinical development of such specific or ‘new targeted’ agents in cancer requires a comprehensive understanding of the target protein. This understanding is expected to improve the identification of patients who most likely will benefit from treatment with a specific inhibitor, such as aprinocarsen. In order to better understand the role of PKC-α in nervous system malignancies we here review the published literature on PKC-α expression in nervous system tumors, including glioblastoma multiforme. In pre-clinical experiments aprinocarsen had demonstrated anti-tumor activity, in particular in animal models of glioblastoma. Thus, clinical study CS10 with aprinocarsen was undertaken in patients with central nervous system (CNS) malignancies. The results of this study and considerations for future clinical studies in CNS tumors are reviewed.

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Copy and paste a formatted citation
Spandidos Publications style
Lahn MM, Sundell KL and Paterson BM: The role of protein kinase C-α in malignancies of the nervous system and implications for the clinical development of the specific PKC-α inhibitor aprinocarsen (Review). Oncol Rep 11: 515-522, 2004.
APA
Lahn, M.M., Sundell, K.L., & Paterson, B.M. (2004). The role of protein kinase C-α in malignancies of the nervous system and implications for the clinical development of the specific PKC-α inhibitor aprinocarsen (Review). Oncology Reports, 11, 515-522. https://doi.org/10.3892/or.11.2.515
MLA
Lahn, M. M., Sundell, K. L., Paterson, B. M."The role of protein kinase C-α in malignancies of the nervous system and implications for the clinical development of the specific PKC-α inhibitor aprinocarsen (Review)". Oncology Reports 11.2 (2004): 515-522.
Chicago
Lahn, M. M., Sundell, K. L., Paterson, B. M."The role of protein kinase C-α in malignancies of the nervous system and implications for the clinical development of the specific PKC-α inhibitor aprinocarsen (Review)". Oncology Reports 11, no. 2 (2004): 515-522. https://doi.org/10.3892/or.11.2.515
Copy and paste a formatted citation
x
Spandidos Publications style
Lahn MM, Sundell KL and Paterson BM: The role of protein kinase C-α in malignancies of the nervous system and implications for the clinical development of the specific PKC-α inhibitor aprinocarsen (Review). Oncol Rep 11: 515-522, 2004.
APA
Lahn, M.M., Sundell, K.L., & Paterson, B.M. (2004). The role of protein kinase C-α in malignancies of the nervous system and implications for the clinical development of the specific PKC-α inhibitor aprinocarsen (Review). Oncology Reports, 11, 515-522. https://doi.org/10.3892/or.11.2.515
MLA
Lahn, M. M., Sundell, K. L., Paterson, B. M."The role of protein kinase C-α in malignancies of the nervous system and implications for the clinical development of the specific PKC-α inhibitor aprinocarsen (Review)". Oncology Reports 11.2 (2004): 515-522.
Chicago
Lahn, M. M., Sundell, K. L., Paterson, B. M."The role of protein kinase C-α in malignancies of the nervous system and implications for the clinical development of the specific PKC-α inhibitor aprinocarsen (Review)". Oncology Reports 11, no. 2 (2004): 515-522. https://doi.org/10.3892/or.11.2.515
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