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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2004 Volume 11 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2004 Volume 11 Issue 2

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Article

Increased mRNA expression of ADAMs in renal cell carcinoma and their association with clinical outcome

  • Authors:
    • Andreas Roemer
    • Lutz Schwettmann
    • Monika Jung
    • Jan Roigas
    • Glen Kristiansen
    • Dietmar Schnorr
    • Stefan A. Loening
    • Klaus Jung
    • Ralf Lichtinghagen

  • View Affiliations / Copyright

    Affiliations: Department of Urology, University Hospital Charité, Humboldt University, Berlin, Germany
  • Pages: 529-536
    |
    Published online on: February 1, 2004
       https://doi.org/10.3892/or.11.2.529
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Abstract

ADAMs (a disintegrin and metalloproteinase) are cell-surface proteins with adhesion and protease activity which play important roles in many biological processes. Little is known about their role in cancer. The aim of the study was to assess the quantitative expression of the ADAMs in human renal cell carcinoma (RCC) and to associate expression levels with clinicopathological data. We investigated the mRNA expression of ADAM-8, -17, -19, -28, ADAM-TS1, and ADAM-TS2 in paired tissue samples from cancerous and non-cancerous parts of the kidneys of 27 patients with RCC who underwent tumour nephrectomy. Measurements were performed by means of the quantitative real-time RT-PCR on a LightCycler instrument. ADAM-8, -17, and -19 were significantly higher expressed (p<0.05 at least) in cancerous compared with the matched non-cancerous tissue in pT1 and ≥pT2 tumours, ADAM-28 and ADAM-TS2 only in pT1 tumours, and ADMA-TS1 was not differently expressed. All ADAMs except ADAM-TS1 showed an increase of expression in the non-cancerous tissue with rising pT stage suggesting an early involvement of ADAMs in the development of RCC. The expression of ADAM-8 was related to a shorter survival of patients and was the best predictor of distant metastases. Our results indicate a potential role for ADAMs in RCC and that the overexpression might be a useful predictive tool.

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Copy and paste a formatted citation
Spandidos Publications style
Roemer A, Schwettmann L, Jung M, Roigas J, Kristiansen G, Schnorr D, Loening SA, Jung K and Lichtinghagen R: Increased mRNA expression of ADAMs in renal cell carcinoma and their association with clinical outcome. Oncol Rep 11: 529-536, 2004.
APA
Roemer, A., Schwettmann, L., Jung, M., Roigas, J., Kristiansen, G., Schnorr, D. ... Lichtinghagen, R. (2004). Increased mRNA expression of ADAMs in renal cell carcinoma and their association with clinical outcome. Oncology Reports, 11, 529-536. https://doi.org/10.3892/or.11.2.529
MLA
Roemer, A., Schwettmann, L., Jung, M., Roigas, J., Kristiansen, G., Schnorr, D., Loening, S. A., Jung, K., Lichtinghagen, R."Increased mRNA expression of ADAMs in renal cell carcinoma and their association with clinical outcome". Oncology Reports 11.2 (2004): 529-536.
Chicago
Roemer, A., Schwettmann, L., Jung, M., Roigas, J., Kristiansen, G., Schnorr, D., Loening, S. A., Jung, K., Lichtinghagen, R."Increased mRNA expression of ADAMs in renal cell carcinoma and their association with clinical outcome". Oncology Reports 11, no. 2 (2004): 529-536. https://doi.org/10.3892/or.11.2.529
Copy and paste a formatted citation
x
Spandidos Publications style
Roemer A, Schwettmann L, Jung M, Roigas J, Kristiansen G, Schnorr D, Loening SA, Jung K and Lichtinghagen R: Increased mRNA expression of ADAMs in renal cell carcinoma and their association with clinical outcome. Oncol Rep 11: 529-536, 2004.
APA
Roemer, A., Schwettmann, L., Jung, M., Roigas, J., Kristiansen, G., Schnorr, D. ... Lichtinghagen, R. (2004). Increased mRNA expression of ADAMs in renal cell carcinoma and their association with clinical outcome. Oncology Reports, 11, 529-536. https://doi.org/10.3892/or.11.2.529
MLA
Roemer, A., Schwettmann, L., Jung, M., Roigas, J., Kristiansen, G., Schnorr, D., Loening, S. A., Jung, K., Lichtinghagen, R."Increased mRNA expression of ADAMs in renal cell carcinoma and their association with clinical outcome". Oncology Reports 11.2 (2004): 529-536.
Chicago
Roemer, A., Schwettmann, L., Jung, M., Roigas, J., Kristiansen, G., Schnorr, D., Loening, S. A., Jung, K., Lichtinghagen, R."Increased mRNA expression of ADAMs in renal cell carcinoma and their association with clinical outcome". Oncology Reports 11, no. 2 (2004): 529-536. https://doi.org/10.3892/or.11.2.529
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