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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2004 Volume 11 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Correlation among loss of heterozygosity, promoter methylation and protein expression of MLH1 in larynx cancer

  • Authors:
    • Robert Smigiel
    • Agnieszka Stembalska-Kozlowska
    • Farhad Mirghomizadeh
    • Tomasz Krecicki
    • Tomasz Zatonski
    • David Ramsey
    • Monika Horobiowska
    • Jozef Jagielski
    • Nikolaus Blin
    • Maria Sasiadek

  • View Affiliations / Copyright

    Affiliations: Department of Pathophysiology, Medical University of Wroclaw, 50-368 Wroclaw, Poland
  • Pages: 707-710
    |
    Published online on: March 1, 2004
       https://doi.org/10.3892/or.11.3.707
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Abstract

Extensive molecular studies in development of the squamous cell carcinoma of larynx (SCCL) indicated the involvement of a variety of genes including the MLH1. To search for possible mechanism leading to MLH1 silencing in SCCL we studied LOH and promoter methylation in a homogeneous set of 62 larynx cancers. Then we evaluated immunohistochemically the MLH1 expression for 51 tumor specimens. Further, the results were correlated with microsatellite instability and subsequently with the clinical course of the disease. LOH at the MLH1 locus and aberrant methylation of its promoter were found in 47.9 and in 22.6% of tumors, respectively. A decreased expression was observed in 27.5% of the cases. MSI analysis of tumor DNA showed a microsatellite stable phenotype in 59 cases (95.2%). From our study it can be concluded that: i) molecular alterations of MLH1 play an important role in SSCL development, ii) both LOH and aberrant methylation contribute to the MLH1 inactivation in SCCL and are associated with a less advanced stage of differentiation of larynx tumors, iii) MLH1 inactivation does not lead to MSI in larynx cancer and MSI may not contribute to the development of SCCL.

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Copy and paste a formatted citation
Spandidos Publications style
Smigiel R, Stembalska-Kozlowska A, Mirghomizadeh F, Krecicki T, Zatonski T, Ramsey D, Horobiowska M, Jagielski J, Blin N, Sasiadek M, Sasiadek M, et al: Correlation among loss of heterozygosity, promoter methylation and protein expression of MLH1 in larynx cancer. Oncol Rep 11: 707-710, 2004.
APA
Smigiel, R., Stembalska-Kozlowska, A., Mirghomizadeh, F., Krecicki, T., Zatonski, T., Ramsey, D. ... Sasiadek, M. (2004). Correlation among loss of heterozygosity, promoter methylation and protein expression of MLH1 in larynx cancer. Oncology Reports, 11, 707-710. https://doi.org/10.3892/or.11.3.707
MLA
Smigiel, R., Stembalska-Kozlowska, A., Mirghomizadeh, F., Krecicki, T., Zatonski, T., Ramsey, D., Horobiowska, M., Jagielski, J., Blin, N., Sasiadek, M."Correlation among loss of heterozygosity, promoter methylation and protein expression of MLH1 in larynx cancer". Oncology Reports 11.3 (2004): 707-710.
Chicago
Smigiel, R., Stembalska-Kozlowska, A., Mirghomizadeh, F., Krecicki, T., Zatonski, T., Ramsey, D., Horobiowska, M., Jagielski, J., Blin, N., Sasiadek, M."Correlation among loss of heterozygosity, promoter methylation and protein expression of MLH1 in larynx cancer". Oncology Reports 11, no. 3 (2004): 707-710. https://doi.org/10.3892/or.11.3.707
Copy and paste a formatted citation
x
Spandidos Publications style
Smigiel R, Stembalska-Kozlowska A, Mirghomizadeh F, Krecicki T, Zatonski T, Ramsey D, Horobiowska M, Jagielski J, Blin N, Sasiadek M, Sasiadek M, et al: Correlation among loss of heterozygosity, promoter methylation and protein expression of MLH1 in larynx cancer. Oncol Rep 11: 707-710, 2004.
APA
Smigiel, R., Stembalska-Kozlowska, A., Mirghomizadeh, F., Krecicki, T., Zatonski, T., Ramsey, D. ... Sasiadek, M. (2004). Correlation among loss of heterozygosity, promoter methylation and protein expression of MLH1 in larynx cancer. Oncology Reports, 11, 707-710. https://doi.org/10.3892/or.11.3.707
MLA
Smigiel, R., Stembalska-Kozlowska, A., Mirghomizadeh, F., Krecicki, T., Zatonski, T., Ramsey, D., Horobiowska, M., Jagielski, J., Blin, N., Sasiadek, M."Correlation among loss of heterozygosity, promoter methylation and protein expression of MLH1 in larynx cancer". Oncology Reports 11.3 (2004): 707-710.
Chicago
Smigiel, R., Stembalska-Kozlowska, A., Mirghomizadeh, F., Krecicki, T., Zatonski, T., Ramsey, D., Horobiowska, M., Jagielski, J., Blin, N., Sasiadek, M."Correlation among loss of heterozygosity, promoter methylation and protein expression of MLH1 in larynx cancer". Oncology Reports 11, no. 3 (2004): 707-710. https://doi.org/10.3892/or.11.3.707
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